PMID- 34766714
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20231213
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Linking)
VI  - 36
IP  - 2
DP  - 2022 Feb
TI  - Protective effects of rosmarinic acid against azoxymethane-induced colorectal 
      cancer in rats.
PG  - e22961
LID - 10.1002/jbt.22961 [doi]
AB  - Colorectal cancer (CRC) incidence is increasing gradually and has been become one 
      of the most common cancers worldwide. Hence, it is important to discover cheap, 
      naturally occurring compounds to be effective in suppressing the devastating 
      effect of colon-related tumors. Rosmarinic acid (RA), one of the compounds of 
      plant origin, possesses attractive features for use as an agent for cancer 
      prevention and treatment. This study investigated the ability of RA to prevent 
      azoxymethane (AOM)-induced rat colon carcinogenesis by evaluating the effect of 
      RA on tumor formation and circulatory oxidant-antioxidant status. Moreover, 
      plasma levels of adiponectin (APN) monocyte chemoattractant protein-1 (MCP-1), 
      interleukin-6 (IL-6) were detected by enzyme linked immunosorbent assay. The 
      animals were divided into three groups: Control, AOM, and AOM + RA. Rats were fed 
      a modified pellet diet (15.8% peanut oil was added to the standard diet) during 
      the experimental period. Colon cancer was formed by applying 15 mg/kg AOM 
      intraperitoneal once a week for 4 weeks in both the CRC group and AOM + RA group. 
      Besides AOM, AOM + RA group received 5 mg/kg body weight RA orally every day 
      during the study. The results showed that adenocarcinoma rates formed 87.5% 
      of the AOM group. With treatment of RA, a reduction in the incidence of 
      adenocarcinoma was observed in the AOM + RA group. The plasma MCP-1, IL-6, and TO 
      levels were significantly higher, APN and TAS levels were significantly lower in 
      the AOM group with respect to controls. In addition, there was a significant 
      increase in TAS levels in the RA treatment group compared to the AOM group. These 
      findings suggested that RA may be beneficial in preventing AOM-induced colon 
      carcinogenesis formation.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Ilhan, Nevin
AU  - Ilhan N
AUID- ORCID: 0000-0002-0208-8929
AD  - Department of Medical Biochemistry, Medical Faculty, Firat University, Elazig, 
      Turkey.
FAU - Bektas, Ibrahim
AU  - Bektas I
AUID- ORCID: 0000-0001-9430-9735
AD  - Department of Medical Biochemistry, Medical Faculty, Firat University, Elazig, 
      Turkey.
FAU - Susam, Solmaz
AU  - Susam S
AUID- ORCID: 0000-0002-7503-2416
AD  - Department of Medical Biochemistry, Medical Faculty, Adiyaman University, 
      Adiyaman, Turkey.
FAU - Ozercan, Ibrahim H
AU  - Ozercan IH
AUID- ORCID: 0000-0002-8781-8838
AD  - Department of Medical Pathology, Medical Faculty, Firat University, Elazig, 
      Turkey.
LA  - eng
GR  - TF.12.65./Firat University Scientific Research Projects Unit/
PT  - Journal Article
DEP - 20211112
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Azo Compounds)
RN  - 0 (Cinnamates)
RN  - 0 (Depsides)
RN  - 503-28-6 (azomethane)
SB  - IM
MH  - Animals
MH  - Azo Compounds/*toxicity
MH  - Cinnamates/*pharmacology
MH  - *Colorectal Neoplasms/chemically induced/metabolism/prevention & control
MH  - Depsides/*pharmacology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rosmarinic Acid
OTO - NOTNLM
OT  - MCP-1
OT  - adiponectin
OT  - colorectal cancer
OT  - oxidative stress
OT  - rosmarinic acid
EDAT- 2021/11/13 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/11/12 08:50
PHST- 2021/08/10 00:00 [revised]
PHST- 2021/03/31 00:00 [received]
PHST- 2021/10/18 00:00 [accepted]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/11/12 08:50 [entrez]
AID - 10.1002/jbt.22961 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2022 Feb;36(2):e22961. doi: 10.1002/jbt.22961. Epub 2021 
      Nov 12.