PMID- 34766729
OWN - NLM
STAT- MEDLINE
DCOM- 20220304
LR  - 20220304
IS  - 1864-0648 (Electronic)
IS  - 1864-063X (Linking)
VI  - 15
IP  - 2
DP  - 2022 Feb
TI  - Assessment of diabetic small-fiber neuropathy by using short-wave infrared 
      hyperspectral imaging.
PG  - e202100220
LID - 10.1002/jbio.202100220 [doi]
AB  - Among patients with type 2 diabetes mellitus (T2DM), the association between 
      hyperspectral imaging (HSI) examination and diabetic neuropathy (DN) is 
      ascertained using HSI of the feet using four types of spectral difference 
      measurements. DN was evaluated by traditional Michigan Neuropathy Screening 
      Instrument (MNSI), evaluation of painful neuropathy (ID-Pain, DN4) and sudomotor 
      function by measuring electrochemical skin conductance (ESC). Of the 120 T2DM 
      patients and 20 healthy adults enrolled, T2DM patients are categorized into 
      normal sudomotor (ESC >60 muS) and sudomotor dysfunction (ESC </= 60 muS) groups. 
      Spectral difference analyses reveal significant intergroup differences, whereas 
      traditional examinations cannot distinguish between the two groups. HSI waveform 
      reflectance gradually increases with disease severity, at 1400 to 1600 nm. The 
      area under the curve (AUC) of receiver operating characteristic (ROC) analysis 
      for abnormal ESC is >/=0.8 for all four HSI methods. HSI could be an objective, 
      sensitive, rapid, noninvasive and remote approach to identify early small-fiber 
      DN.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Sheen, Yi-Jing
AU  - Sheen YJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - Department of Medicine, School of Medicine, National Yang-Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Sheu, Wayne Huey-Herng
AU  - Sheu WH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - Department of Medicine, School of Medicine, National Yang-Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Institute of Medical Technology, College of Life Science, National Chung-Hsing 
      University, Taichung, Taiwan.
AD  - School of Medicine, National Defense Medical Center, Taipei, Taiwan.
FAU - Wang, Hsin-Che
AU  - Wang HC
AD  - Research and Development Department, ISUZU Optics, Hsinchu, Taiwan.
AD  - Center for Quantitative Imaging in Medicine (CQUIM), Department of Medical 
      Research, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Chen, Jun-Peng
AU  - Chen JP
AD  - Biostatistics Task Force, Department of Medical Research, Taichung Veterans 
      General Hospital, Taichung, Taiwan.
FAU - Sun, Yi-Hsuan
AU  - Sun YH
AD  - Center for Quantitative Imaging in Medicine (CQUIM), Department of Medical 
      Research, Taichung Veterans General Hospital, Taichung, Taiwan.
FAU - Chen, Hsian-Min
AU  - Chen HM
AUID- ORCID: 0000-0002-8409-3237
AD  - Center for Quantitative Imaging in Medicine (CQUIM), Department of Medical 
      Research, Taichung Veterans General Hospital, Taichung, Taiwan.
AD  - Department of Biomedical Engineering, Hung Kuang University, Taichung, Taiwan.
AD  - Department of Computer Science & Information Engineering, National United 
      University, Miaoli, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211122
PL  - Germany
TA  - J Biophotonics
JT  - Journal of biophotonics
JID - 101318567
SB  - IM
MH  - Adult
MH  - *Diabetes Mellitus, Type 2/complications/diagnostic imaging
MH  - *Diabetic Neuropathies/diagnostic imaging
MH  - Foot
MH  - Galvanic Skin Response
MH  - Humans
MH  - Hyperspectral Imaging
OTO - NOTNLM
OT  - diabetic neuropathy (DN)
OT  - electrochemical skin conductance (ESC)
OT  - hyperspectral imaging (HSI)
OT  - short-wave infrared (SWIR)
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2021/11/13 06:00
MHDA- 2022/03/05 06:00
CRDT- 2021/11/12 08:51
PHST- 2021/09/02 00:00 [revised]
PHST- 2021/07/18 00:00 [received]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2021/11/13 06:00 [pubmed]
PHST- 2022/03/05 06:00 [medline]
PHST- 2021/11/12 08:51 [entrez]
AID - 10.1002/jbio.202100220 [doi]
PST - ppublish
SO  - J Biophotonics. 2022 Feb;15(2):e202100220. doi: 10.1002/jbio.202100220. Epub 2021 
      Nov 22.