PMID- 34768531
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211118
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 21
DP  - 2021 Oct 28
TI  - Spinal Manipulative Therapy for Acute Neck Pain: A Systematic Review and 
      Meta-Analysis of Randomised Controlled Trials.
LID - 10.3390/jcm10215011 [doi]
LID - 5011
AB  - (1) Background: Acute neck pain is common and usually managed by medication 
      and/or manual therapy. General practitioners (GPs) hesitate to refer to manual 
      therapy due to uncertainty about the effectiveness and adverse events (AEs); (2) 
      Method: To review original randomized controlled trials (RCTs) assessing the 
      effect of spinal manipulative therapy (SMT) for acute neck pain. Data extraction 
      was done in duplicate and formulated in tables. Quality and evidence were 
      assessed using the Cochrane Back and Neck (CBN) Risk of Bias tool and the Grading 
      of Recommendations Assessment, Development, and Evaluation (GRADE) criteria, 
      respectively; (3) Results: Six studies were included. The overall pooled effect 
      size for neck pain was very large -1.37 (95% CI, -2.41, -0.34), favouring 
      treatments with SMT compared with controls. A single study that showed that SMT 
      was statistically significantly better than medicine (30 mg ketorolac im.) one 
      day post-treatment, ((-2.8 (46%) (95% CI, -2.1, -3.4) vs. -1.7 (30%) (95% CI, 
      -1.1, -2.3), respectively; p = 0.02)). Minor transient AEs reported included 
      increased pain and headache, while no serious AEs were reported; (4) Conclusions: 
      SMT alone or in combination with other modalities was effective for patients with 
      acute neck pain. However, limited quantity and quality, pragmatic design, and 
      high heterogeneity limit our findings.
FAU - Chaibi, Aleksander
AU  - Chaibi A
AUID- ORCID: 0000-0003-2566-5984
AD  - Head and Neck Research Group, Division for Research and Innovation, Akershus 
      University Hospital, 1478 Oslo, Norway.
AD  - Department for Interdisciplinary Health Sciences, Faculty of Medicine, Institute 
      of Health and Society, University of Oslo, 0317 Oslo, Norway.
FAU - Stavem, Knut
AU  - Stavem K
AUID- ORCID: 0000-0003-4512-8000
AD  - Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 
      1478 Nordbyhagen, Norway.
AD  - Department of Pulmonary Medicine, Akershus University Hospital, 1478 Lorenskog, 
      Norway.
AD  - Health Services Research Unit, Akershus University Hospital, 1478 Lorenskog, 
      Norway.
FAU - Russell, Michael Bjorn
AU  - Russell MB
AD  - Head and Neck Research Group, Division for Research and Innovation, Akershus 
      University Hospital, 1478 Oslo, Norway.
AD  - Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 
      1478 Nordbyhagen, Norway.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211028
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8584283
OTO - NOTNLM
OT  - acute neck pain
OT  - appropriateness
OT  - chiropractic
OT  - effectiveness
OT  - meta-analysis
OT  - osteopath
OT  - physiotherapy
OT  - randomized controlled trial
OT  - spinal manipulation
OT  - systematic review
COIS- The authors have completed the ICMJE uniform disclosure form and declare no 
      potential conflict of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/11/14 06:00
MHDA- 2021/11/14 06:01
PMCR- 2021/10/28
CRDT- 2021/11/13 01:02
PHST- 2021/09/26 00:00 [received]
PHST- 2021/10/13 00:00 [revised]
PHST- 2021/10/26 00:00 [accepted]
PHST- 2021/11/13 01:02 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2021/11/14 06:01 [medline]
PHST- 2021/10/28 00:00 [pmc-release]
AID - jcm10215011 [pii]
AID - jcm-10-05011 [pii]
AID - 10.3390/jcm10215011 [doi]
PST - epublish
SO  - J Clin Med. 2021 Oct 28;10(21):5011. doi: 10.3390/jcm10215011.