PMID- 34771112
OWN - NLM
STAT- MEDLINE
DCOM- 20211206
LR  - 20211214
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 26
IP  - 21
DP  - 2021 Nov 5
TI  - Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active 
      Ingredient against Acne: In Vitro and In Vivo Efficacy Assays.
LID - 10.3390/molecules26216704 [doi]
LID - 6704
AB  - In addition to dermatological complications, acne can affect the quality of life 
      of individuals in numerous ways, such as employment, social habits and body 
      dissatisfaction. According to our expertise, caprylic acid and propanediol would 
      not have a direct action on Cutibacterium acnes. Despite this, we investigated 
      the existence of a synergistic effect among xylitol, caprylic acid and 
      propanediol as a mixture of compounds representing a single topical active 
      ingredient that could benefit the treatment against acne. In vitro and in vivo 
      assays were performed to challenge and to prove the efficacy of propanediol, 
      xylitol and caprylic acid (PXCA) against acne. PXCA had its MIC challenged 
      against C. acnes (formerly Propionibacterium acnes) and Staphylococcus aureus, 
      resulting in concentrations of 0.125% and 0.25%, respectively, and it also 
      developed antimicrobial activity against C. acnes (time-kill test). PXCA was able 
      to reduce the 5-alpha reductase expression in 24% (p < 0.01) in comparison with 
      the testosterone group. By the end of 28 days of treatment, the compound reduced 
      the skin oiliness, porphyrin amount and the quantity of inflammatory lesions in 
      participants. According to the dermatologist evaluation, PXCA improved the skin's 
      general appearance, acne presence and size.
FAU - Mussi, Lilian
AU  - Mussi L
AD  - Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, Brazil.
FAU - Baby, Andre Rolim
AU  - Baby AR
AUID- ORCID: 0000-0001-9197-3024
AD  - Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao 
      Paulo, 05508-000 Sao Paulo, Brazil.
FAU - Camargo Junior, Flavio Bueno
AU  - Camargo Junior FB
AD  - Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, Brazil.
FAU - Padovani, Giovana
AU  - Padovani G
AD  - Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, Brazil.
FAU - Sufi, Bianca da Silva
AU  - Sufi BDS
AD  - Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, Brazil.
FAU - Magalhaes, Wagner Vidal
AU  - Magalhaes WV
AD  - Research and Development Department, Chemyunion Ltd., 18087-101 Sorocaba, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20211105
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Caprylates)
RN  - 0 (Propylene Glycols)
RN  - OBL58JN025 (octanoic acid)
RN  - VCQ006KQ1E (Xylitol)
SB  - IM
MH  - Acne Vulgaris/*drug therapy/etiology
MH  - Anti-Bacterial Agents/*administration & dosage/*chemistry
MH  - Anti-Inflammatory Agents/*chemistry/*pharmacology
MH  - Caprylates/*administration & dosage/chemistry
MH  - Clinical Trials as Topic
MH  - Disease Management
MH  - Disease Susceptibility
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - *Propylene Glycols/chemistry
MH  - Staphylococcus aureus/drug effects
MH  - Treatment Outcome
MH  - Xylitol/*administration & dosage/chemistry
PMC - PMC8587458
OTO - NOTNLM
OT  - 5-alpha reductase
OT  - acne
OT  - caprylic acid
OT  - efficacy
OT  - porphyrin
OT  - propanediol
OT  - sebum control
OT  - xylitol
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/14 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/11/05
CRDT- 2021/11/13 01:13
PHST- 2021/10/08 00:00 [received]
PHST- 2021/10/29 00:00 [revised]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/11/13 01:13 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/11/05 00:00 [pmc-release]
AID - molecules26216704 [pii]
AID - molecules-26-06704 [pii]
AID - 10.3390/molecules26216704 [doi]
PST - epublish
SO  - Molecules. 2021 Nov 5;26(21):6704. doi: 10.3390/molecules26216704.