PMID- 34771258
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 13
IP  - 21
DP  - 2021 Oct 27
TI  - Antibacterial and Hemocompatible pH-Responsive Hydrogel for Skin Wound Healing 
      Application: In Vitro Drug Release.
LID - 10.3390/polym13213703 [doi]
LID - 3703
AB  - The treatment of successive skin wounds necessitates meticulous medical 
      procedures. In the care and treatment of skin wounds, hydrogels produced from 
      natural polymers with controlled drug release play a crucial role. Arabinoxylan 
      is a well-known and widely available biological macromolecule. We produced 
      various formulations of blended composite hydrogels (BCHs) from arabinoxylan 
      (ARX), carrageenan (CG), and reduced graphene oxide (rGO) using and cross-linked 
      them with an optimal amount of tetraethyl orthosilicate (TEOS). The structural, 
      morphological, and mechanical behavior of the BCHs samples were determined using 
      Fourier-transform infrared spectroscopy (FT-IR), Scanning electron microscope 
      (SEM), mechanical testing, and wetting, respectively. The swelling and 
      degradation assays were performed in phosphate-buffered saline (PBS) solution and 
      aqueous media. Maximum swelling was observed at pH 7 and the least swelling in 
      basic pH regions. All composite hydrogels were found to be hemocompatible. In 
      vitro, silver sulfadiazine release profile in PBS solution was analyzed via the 
      Franz diffusion method, and maximum drug release (87.9%) was observed in 48 h. 
      The drug release kinetics was studied against different mathematical models 
      (zero-order, first-order, Higuchi, Hixson-Crowell, Korsmeyer-Peppas, and 
      Baker-Lonsdale models) and compared their regression coefficient (R(2)) values. 
      It was observed that drug release follows the Baker-Lonsdale model, as it has the 
      highest value (0.989) of R(2). Hence, the obtained results indicated that, due to 
      optimized swelling, wetting, and degradation, the blended composite hydrogel 
      BCH-3 could be an essential wound dressing biomaterial for sustained drug release 
      for skin wound care and treatment.
FAU - Khan, Muhammad Umar Aslam
AU  - Khan MUA
AUID- ORCID: 0000-0002-2724-1336
AD  - BioInspired Device and Tissue Engineering Research Group, School of Biomedical 
      Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi 
      Malaysia, Skudai 81300, Johor, Malaysia.
AD  - Institute of Personalized Medicine, School of Biomedical Engineering, Med-X 
      Research Institute, Shanghai Jiao Tong University (SJTU),1954 Huashan Road, 
      Shanghai 200030, China.
AD  - Nanosciences and Technology Department (NS & TD), National Center for Physics, 
      Quaid-i-Azam University Campus, Islamabad 44000, Pakistan.
FAU - Razaq, Saiful Izwan Abd
AU  - Razaq SIA
AUID- ORCID: 0000-0001-7477-0284
AD  - Institute of Personalized Medicine, School of Biomedical Engineering, Med-X 
      Research Institute, Shanghai Jiao Tong University (SJTU),1954 Huashan Road, 
      Shanghai 200030, China.
AD  - Centre for Advanced Composite Materials Universiti Teknologi Malaysia Skudai, 
      Johor Bahru 81310, Johor, Malaysia.
FAU - Mehboob, Hassan
AU  - Mehboob H
AUID- ORCID: 0000-0003-1184-1326
AD  - Department of Engineering Management, College of Engineering, Prince Sultan 
      University, Rafha Street, P.O. Box 66833, Riyadh 11586, Saudi Arabia.
FAU - Rehman, Sarish
AU  - Rehman S
AD  - Chemistry Department, McGill University, 801 Sherbrooke St. W, Montreal, QC 
      H3A0G4, Canada.
FAU - Al-Arjan, Wafa Shamsan
AU  - Al-Arjan WS
AD  - Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 
      31982, Saudi Arabia.
FAU - Amin, Rashid
AU  - Amin R
AD  - Department of Biology, College of Sciences, University of Hafr Al Batin, Hafar 
      Al-Batin 39524, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20211027
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC8588096
OTO - NOTNLM
OT  - antibacterial
OT  - biomaterials
OT  - biopolymers
OT  - controlled drug release
OT  - hemocompatibility
OT  - kinetics studies
OT  - wound dressing
COIS- All authors declared no conflict of interest.
EDAT- 2021/11/14 06:00
MHDA- 2021/11/14 06:01
PMCR- 2021/10/27
CRDT- 2021/11/13 01:13
PHST- 2021/10/06 00:00 [received]
PHST- 2021/10/20 00:00 [revised]
PHST- 2021/10/21 00:00 [accepted]
PHST- 2021/11/13 01:13 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2021/11/14 06:01 [medline]
PHST- 2021/10/27 00:00 [pmc-release]
AID - polym13213703 [pii]
AID - polymers-13-03703 [pii]
AID - 10.3390/polym13213703 [doi]
PST - epublish
SO  - Polymers (Basel). 2021 Oct 27;13(21):3703. doi: 10.3390/polym13213703.