PMID- 34771561
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211118
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 13
IP  - 21
DP  - 2021 Oct 27
TI  - Lymphoma-Associated Biomarkers Are Increased in Current Smokers in Twin Pairs 
      Discordant for Smoking.
LID - 10.3390/cancers13215395 [doi]
LID - 5395
AB  - Smoking is associated with a moderate increased risk of Hodgkin and follicular 
      lymphoma. To understand why, we examined lymphoma-related biomarker levels among 
      134 smoking and non-smoking twins (67 pairs) ascertained from the Finnish Twin 
      Cohort. Previously collected frozen serum samples were tested for cotinine to 
      validate self-reported smoking history. In total, 27 immune biomarkers were 
      assayed using the Luminex Multiplex platform (R & D Systems). Current and 
      non-current smokers were defined by a serum cotinine concentration of >3.08 ng/mL 
      and </=3.08 ng/mL, respectively. Associations between biomarkers and smoking were 
      assessed using linear mixed models to estimate beta coefficients and standard 
      errors, adjusting for age, sex and twin pair as a random effect. There were 55 
      never smokers, 43 current smokers and 36 former smokers. CCL17/TARC, sgp130, 
      haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant 
      protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking 
      and correlated with increasing cotinine concentrations (P(trend) < 0.05). The 
      strongest association was observed for CCL17/TARC (P(trend) = 0.0001). Immune 
      biomarker levels were similar in former and never smokers. Current smoking is 
      associated with increased levels of lymphoma-associated biomarkers, suggesting a 
      possible mechanism for the link between smoking and risk of these two B-cell 
      lymphomas.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Conti, David V
AU  - Conti DV
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
AD  - Center for Genetic Epidemiology, Keck School of Medicine, University of Southern 
      California, Los Angeles, CA 90089, USA.
FAU - Epeldegui, Marta
AU  - Epeldegui M
AUID- ORCID: 0000-0002-7605-5994
AD  - Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Ollikainen, Miina
AU  - Ollikainen M
AD  - Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 
      Helsinki, Finland.
FAU - Tyndale, Rachel F
AU  - Tyndale RF
AUID- ORCID: 0000-0003-1297-2053
AD  - Centre for Addiction and Mental Health, Departments of Pharmacology & Toxicology, 
      and Psychiatry, University of Toronto, and Campbell Family Mental Health Research 
      Institute, Toronto, ON M5S 1A8, Canada.
FAU - Hwang, Amie Eunah
AU  - Hwang AE
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
FAU - Magpantay, Larry
AU  - Magpantay L
AD  - Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Mack, Thomas McCulloch
AU  - Mack TM
AD  - Department of Preventive Medicine, Keck School of Medicine, University of 
      Southern California, Los Angeles, CA 90089, USA.
AD  - Department of Pathology, Keck School of Medicine, University of Southern 
      California, Los Angeles, CA 90089, USA.
FAU - Martinez-Maza, Otoniel
AU  - Martinez-Maza O
AD  - Department of Obstetrics and Gynecology, AIDS Institute, David Geffen School of 
      Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
AD  - Department of Epidemiology, Fielding School of Public Health, University of 
      California Los Angeles, Los Angeles, CA 90095, USA.
AD  - Microbiology and Immunology, David Geffen School of Medicine, University of 
      California Los Angeles, Los Angeles, CA 90095, USA.
FAU - Kaprio, Jaakko
AU  - Kaprio J
AUID- ORCID: 0000-0002-3716-2455
AD  - Department of Public Health, Faculty of Medicine, University of Helsinki, 00014 
      Helsinki, Finland.
AD  - Institute for Molecular Medicine, University of Helsinki, 00014 Helsinki, 
      Finland.
FAU - Cozen, Wendy
AU  - Cozen W
AD  - Department of Medicine, Division of Hematology-Oncology, School of Medicine, 
      University of California Irvine, Orange, CA 92868, USA.
AD  - Department of Pathology, School of Medicine, University of California Irvine, 
      Orange, CA 92868, USA.
AD  - Department of Epidemiology, School of Population Health, Susan and Henry Samueli 
      College of Health Sciences, University of California Irvine, Irvine, CA 92697, 
      USA.
LA  - eng
GR  - RT-01077H, 6RT-0354H/California Tobacco-Related Disease Program/
GR  - 265240, 263278, 308248, 312073, 336823/Academy of Finland/
GR  - 154294/Canada Excellence Research Chairs, Government of Canada/
GR  - NA/STOP CANCER, Norris Comprehensive Cancer Center Foundation/
GR  - NA/Sigrid Juselius Foundation/
GR  - NA/Centre for Addiction and Mental Health/
PT  - Journal Article
DEP - 20211027
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC8582438
OTO - NOTNLM
OT  - BAFF
OT  - Hodgkin lymphoma
OT  - MCP1
OT  - TARC/CCL17
OT  - biomarkers
OT  - chemokines
OT  - cytokines
OT  - follicular lymphoma
OT  - smoking
OT  - spg130
OT  - twins
COIS- R.F.T. has consulted for Quinn Emanuel and Ethismos Research Inc on unrelated 
      topics.
EDAT- 2021/11/14 06:00
MHDA- 2021/11/14 06:01
PMCR- 2021/10/27
CRDT- 2021/11/13 01:14
PHST- 2021/09/17 00:00 [received]
PHST- 2021/10/19 00:00 [accepted]
PHST- 2021/11/13 01:14 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2021/11/14 06:01 [medline]
PHST- 2021/10/27 00:00 [pmc-release]
AID - cancers13215395 [pii]
AID - cancers-13-05395 [pii]
AID - 10.3390/cancers13215395 [doi]
PST - epublish
SO  - Cancers (Basel). 2021 Oct 27;13(21):5395. doi: 10.3390/cancers13215395.