PMID- 34771821
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240407
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 14
IP  - 21
DP  - 2021 Oct 22
TI  - Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous 
      Scaffolds for Tissue Engineering.
LID - 10.3390/ma14216295 [doi]
LID - 6295
AB  - Electrospinning is an innovative new fibre technology that aims to design and 
      fabricate membranes suitable for a wide range of tissue engineering (TE) 
      applications including vascular grafts, which is the main objective of this 
      research work. This study dealt with fabricating and characterising bilayer 
      structures comprised of an electrospun sheet made of polycaprolactone (PCL, inner 
      layer) and an outer layer made of poly lactic-co-glycolic acid (PLGA) and a 
      coaxial porous scaffold with a micrometre fibre structure was successfully 
      produced. The membranes' propriety for intended biomedical applications was 
      assessed by evaluating their morphological structure/physical properties and 
      structural integrity when they underwent the degradation process. A scanning 
      electron microscope (SEM) was used to assess changes in the electrospun 
      scaffolds' structural morphology such as in their fibre diameter, pore size (mum) 
      and the porosity of the scaffold surface which was measured with Image J 
      software. During the 12-week degradation process at room temperature, most of the 
      scaffolds showed a similar trend in their degradation rate except the 60 min 
      scaffolds. The coaxial scaffold had significantly less mass loss than the bilayer 
      PCL/PLGA scaffold with 1.348% and 18.3%, respectively. The mechanical properties 
      of the fibrous membranes were measured and the coaxial scaffolds showed greater 
      tensile strength and elongation at break (%) compared to the bilayer scaffolds. 
      According to the results obtained in this study, it can be concluded that a 
      scaffold made with a coaxial needle is more suitable for tissue engineering 
      applications due to the improved quality and functionality of the resulting 
      polymeric membrane compared to the basic electrospinning process. However, whilst 
      fabricating a vascular graft is the main aim of this research work, the 
      biological data will not present in this paper.
FAU - Bazgir, Morteza
AU  - Bazgir M
AD  - Department of Biomedical and Electronics Engineering, School of Engineering, 
      University of Bradford, Bradford BD7 1DP, UK.
FAU - Zhang, Wei
AU  - Zhang W
AUID- ORCID: 0000-0001-5778-9936
AD  - State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute 
      at Sichuan University, Chengdu 610065, China.
AD  - Advanced Polymer Materials Research Center, Sichuan University, Shishi 362700, 
      China.
FAU - Zhang, Ximu
AU  - Zhang X
AD  - Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing 
      Municipal Key Laboratory of Oral Biomedical Engineering, Higher Education and 
      Stomatological Hospital, Chongqing Medical University, Chongqing 401174, China.
FAU - Elies, Jacobo
AU  - Elies J
AUID- ORCID: 0000-0002-2518-8412
AD  - School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of 
      Bradford, Bradford BD7 1DP, UK.
FAU - Saeinasab, Morvarid
AU  - Saeinasab M
AD  - Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, 
      Mashhad 91779-4897, Iran.
FAU - Coates, Phil
AU  - Coates P
AD  - Interdisciplinary Research Centre in Polymer Science and Technology (Polymer 
      IRC), University of Bradford, Bradford BD7 1DP, UK.
FAU - Youseffi, Mansour
AU  - Youseffi M
AUID- ORCID: 0000-0002-4639-1313
AD  - Department of Biomedical and Electronics Engineering, School of Engineering, 
      University of Bradford, Bradford BD7 1DP, UK.
FAU - Sefat, Farshid
AU  - Sefat F
AUID- ORCID: 0000-0002-0911-5213
AD  - Department of Biomedical and Electronics Engineering, School of Engineering, 
      University of Bradford, Bradford BD7 1DP, UK.
AD  - Interdisciplinary Research Centre in Polymer Science and Technology (Polymer 
      IRC), University of Bradford, Bradford BD7 1DP, UK.
LA  - eng
PT  - Journal Article
DEP - 20211022
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC8584973
OTO - NOTNLM
OT  - bilayer
OT  - coaxial
OT  - contact angle
OT  - degradation
OT  - electrospinning
OT  - mechanical properties
OT  - poly lactic-co-glycolic acid (PLGA)
OT  - polycaprolactone (PCL)
COIS- The authors declare no conflict of interest.
EDAT- 2021/11/14 06:00
MHDA- 2021/11/14 06:01
PMCR- 2021/10/22
CRDT- 2021/11/13 01:15
PHST- 2021/08/09 00:00 [received]
PHST- 2021/09/25 00:00 [revised]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/11/13 01:15 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2021/11/14 06:01 [medline]
PHST- 2021/10/22 00:00 [pmc-release]
AID - ma14216295 [pii]
AID - materials-14-06295 [pii]
AID - 10.3390/ma14216295 [doi]
PST - epublish
SO  - Materials (Basel). 2021 Oct 22;14(21):6295. doi: 10.3390/ma14216295.