PMID- 34772976
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20221027
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Nov 12
TI  - Prenatal exposure to persistent organic pollutants and metals and problematic 
      child behavior at 3-5 years of age: a Greenlandic cohort study.
PG  - 22182
LID - 10.1038/s41598-021-01580-0 [doi]
LID - 22182
AB  - High levels of persistent organic pollutants (POPs) and heavy metals are found in 
      Arctic populations. POP and heavy metals are linked to impaired cognitive 
      development. This study examined associations between prenatal POP and metals 
      exposure and problematic child behavior using the Strength and Difficulties 
      Questionnaire (SDQ). POPs and metals were measured in 102 pregnant Greenlandic 
      women. During follow-up at 3-5 years, parents answered an assisted questionnaire 
      including children's SDQ scores. Associations were analyzed using linear and 
      logistic regression analyses and adjusted for maternal plasma cotinine, 
      educational level and age at delivery. In the adjusted analyses, the medium 
      tertile of hexachlorobenzene (beta = 3.06, p = 0.010), beta-hexachlorocyclohexane 
      (beta = 3.58, p = 0.004) and trans-nonachlor (beta = 2.06, p = 0.082) were positively 
      associated with SDQ scores. The continuous cis-nonachlor (OR = 1.09, p = 0.079), 
      dichloro-diphenyl-dichloroethylene (OR = 1.01, p = 0.077), trans-nonachlor 
      (OR = 1.01, p = 0.091), and sum Organochlorine-Pesticides (OR = 1.00, p = 0.094) 
      were positively associated with abnormal SDQ score and the continuous mirex 
      (OR = 1.28, p = 0.096), oxychlordane (OR = 1.04, p = 0.066), and trans-nonachlor 
      (OR = 1.02, p = 0.071) with abnormal hyperactivity score. We found no consistent 
      evidence of associations between polychlorinated biphenyls, perfluoroalkylated 
      substances and heavy metals and problematic behavior. Prenatal organochlorine 
      pesticide exposure associated significantly with problematic behavior in 3-5 year 
      old children.
CI  - (c) 2021. The Author(s).
FAU - Kornvig, Simon
AU  - Kornvig S
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Aarhus, Denmark.
FAU - Wielsoe, Maria
AU  - Wielsoe M
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Aarhus, Denmark.
FAU - Long, Manhai
AU  - Long M
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Aarhus, Denmark.
FAU - Bonefeld-Jorgensen, Eva Cecilie
AU  - Bonefeld-Jorgensen EC
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Aarhus, Denmark. ebj@ph.au.dk.
AD  - Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland. 
      ebj@ph.au.dk.
LA  - eng
GR  - MST-112-00225/Danish Environmental Protection Agency/
GR  - MST-112-00289/Danish Environmental Protection Agency/
PT  - Journal Article
DEP - 20211112
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Metals, Heavy)
SB  - IM
EIN - Sci Rep. 2021 Dec 21;11(1):24462. PMID: 34934157
MH  - Biomarkers/blood
MH  - Child
MH  - *Child Behavior
MH  - Child Behavior Disorders/epidemiology/etiology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Greenland/epidemiology
MH  - Humans
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Metals, Heavy/*adverse effects
MH  - Odds Ratio
MH  - Persistent Organic Pollutants/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Public Health Surveillance
MH  - Surveys and Questionnaires
PMC - PMC8589846
COIS- The authors declare no competing interests.
EDAT- 2021/11/14 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/11/12
CRDT- 2021/11/13 06:00
PHST- 2021/01/28 00:00 [received]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2021/11/13 06:00 [entrez]
PHST- 2021/11/14 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/11/12 00:00 [pmc-release]
AID - 10.1038/s41598-021-01580-0 [pii]
AID - 1580 [pii]
AID - 10.1038/s41598-021-01580-0 [doi]
PST - epublish
SO  - Sci Rep. 2021 Nov 12;11(1):22182. doi: 10.1038/s41598-021-01580-0.