PMID- 34775159
OWN - NLM
STAT- MEDLINE
DCOM- 20230816
LR  - 20230816
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 51
DP  - 2022 Jan-Feb
TI  - A systemic review of endocardial left ventricular pacing.
PG  - 82-86
LID - S0147-9563(21)00266-1 [pii]
LID - 10.1016/j.hrtlng.2021.10.003 [doi]
AB  - BACKGROUND: Endocardial left ventricular pacing is an alternative technique used 
      in cardiac resynchronization therapy (CRT), when placement of a left ventricular 
      lead is not possible via the coronary sinus or in non-responders to conventional 
      CRT. OBJECTIVES: To review the evidence regarding the efficacy and safety of 
      endocardial left ventricular pacing. METHODS: Systematic research on Medline 
      (PubMed), ClinicalTrials.gov and Embase with the terms "endocardial left 
      ventricular pacing", "biventricular pacing" or "endocardial left pacing" was 
      performed with the identification of 1038 results. Eleven studies with 
      endocardial left ventricular pacing patients were included, independent of the 
      technique being applied to naive CRT patients or con non-responders to 
      conventional CRT. The end-point of this analysis was the impact of endocardial 
      left ventricular pacing techniques regarding New York Heart Association (NYHA) 
      functional classification, left ventricular ejection fraction (LVEF) and QRS 
      width, and the occurrence of complications Mean differences (MD) and confidence 
      interval (CI) was used as a measurement of treatment. RESULTS: A total of 560 
      patients were included, with different techniques used (trans-atrial septal 
      technique, trans-ventricular septal technique and transapical technique). 
      Significant improvement was registered in NYHA class (MD 0.73, CI 0.48-0.98, 
      p<0.00001, I(2) = 87%), LVEF (MD -7.63, CI -9.93 - -5.33, p<0.00001, I(2) = 69%) 
      and QRS width (MD 29.25, CI 9.99-48.50, p<0.00001, I(2) = 91%). Several 
      complications were reported after the procedure, 11 pocket infections, 22 
      transient ischemic attacks, 18 ischemic strokes, 41 thromboembolic events, among 
      other complications. The mortality rate during the follow-up was 20.54%. 
      CONCLUSION: Left ventricular endocardial pacing is a feasible alternative to 
      conventional CRT, with clinical, electrocardiographic and echocardiogrphic 
      improvement. However, first data regarding this procedure was associated with 
      significant complications rates.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Santos, Helder
AU  - Santos H
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal. Electronic address: helder33689@gmail.com.
FAU - Santos, Mariana
AU  - Santos M
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal.
FAU - Almeida, Ines
AU  - Almeida I
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal.
FAU - Paula, Sofia B
AU  - Paula SB
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal.
FAU - Figueiredo, Margarida
AU  - Figueiredo M
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal.
FAU - Portugal, Guilherme
AU  - Portugal G
AD  - Centro Hospitalar Universitario de Lisboa Central, Unidade de Arritmologia, 
      Pacing e Eletrofisiologia, Hospital Santa Marta, Lisboa, Portugal.
FAU - Valente, Bruno
AU  - Valente B
AD  - Centro Hospitalar Universitario de Lisboa Central, Unidade de Arritmologia, 
      Pacing e Eletrofisiologia, Hospital Santa Marta, Lisboa, Portugal.
FAU - Silva Cunha, Pedro
AU  - Silva Cunha P
AD  - Centro Hospitalar Universitario de Lisboa Central, Unidade de Arritmologia, 
      Pacing e Eletrofisiologia, Hospital Santa Marta, Lisboa, Portugal.
FAU - Almeida, Lurdes
AU  - Almeida L
AD  - Centro Hospitalar Barreiro-Montijo EPE, Servico de Cardiology, Barreiro, 
      Portugal.
FAU - Oliveira, Mario
AU  - Oliveira M
AD  - Centro Hospitalar Universitario de Lisboa Central, Unidade de Arritmologia, 
      Pacing e Eletrofisiologia, Hospital Santa Marta, Lisboa, Portugal.
LA  - eng
PT  - Journal Article
PT  - Systematic Review
DEP - 20211111
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
SB  - IM
MH  - Humans
MH  - *Cardiac Resynchronization Therapy/adverse effects/methods
MH  - *Heart Failure/therapy
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac resynchronization therapy
OT  - Endocardial left ventricular pacing
OT  - Left ventricular ejection disfunction
OT  - NYHA class
COIS- Conflict of Interest The authors declare that there is no conflict of interest.
EDAT- 2021/11/15 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/11/14 20:57
PHST- 2021/06/23 00:00 [received]
PHST- 2021/10/11 00:00 [revised]
PHST- 2021/10/25 00:00 [accepted]
PHST- 2021/11/15 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/11/14 20:57 [entrez]
AID - S0147-9563(21)00266-1 [pii]
AID - 10.1016/j.hrtlng.2021.10.003 [doi]
PST - ppublish
SO  - Heart Lung. 2022 Jan-Feb;51:82-86. doi: 10.1016/j.hrtlng.2021.10.003. Epub 2021 
      Nov 11.