PMID- 34775260
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20211224
IS  - 2210-7762 (Print)
VI  - 258-259
DP  - 2021 Nov
TI  - Tumor-intrinsic FABP5 is a novel driver for colon cancer cell growth via the 
      HIF-1 signaling pathway.
PG  - 151-156
LID - S2210-7762(21)00220-9 [pii]
LID - 10.1016/j.cancergen.2021.11.001 [doi]
AB  - Dysfunctional lipid metabolism is a known cause of cancer development and 
      progression, yet little is known about the underlying molecular mechanisms that 
      contribute to cancer progression. In this study, we demonstrate that fatty acid 
      binding protein 5 (FABP5) is elevated in colon cancer tissue and this increased 
      expression is linked to upregulation of the hypoxia-inducible factor-1 (HIF-1) 
      signaling pathway. Under physiologically in vivo mimicked conditions via a 
      polydimethylsiloxane (PDMS)-based three-dimensional (3D) culture chip, 
      FABP5-knockdown colon cancer cells exhibited attenuated cell growth throughout 
      the culture period. FABP5 was found to regulate HIF-1alpha protein levels and gene 
      expression levels within the HIF-1alpha signaling pathway under hypoxic conditions. 
      Our results provide evidence that supports the use of FABP5 as a prognostic 
      factor in colon cancer. The FABP5/HIF-1alpha axis is a promising target for 
      ameliorating fatty acid-triggered cancer progression.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Seo, Jieun
AU  - Seo J
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, South Korea; Department of Physiology, Seoul National University 
      College of Medicine, Seoul 03080, South Korea; Faculty of Engineering, Yokohama 
      National University, Yokohama 240-8501, Japan.
FAU - Yun, JeongEun
AU  - Yun J
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, South Korea; Department of Physiology, Seoul National University 
      College of Medicine, Seoul 03080, South Korea.
FAU - Fukuda, Junji
AU  - Fukuda J
AD  - Faculty of Engineering, Yokohama National University, Yokohama 240-8501, Japan.
FAU - Chun, Yang-Sook
AU  - Chun YS
AD  - Department of Biomedical Sciences, Seoul National University College of Medicine, 
      Seoul 03080, South Korea; Department of Physiology, Seoul National University 
      College of Medicine, Seoul 03080, South Korea; Ischemic/Hypoxic Disease 
      Institute, Seoul National University College of Medicine, Seoul 03080, South 
      Korea. Electronic address: chunys@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211105
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Apoptosis
MH  - Cell Proliferation
MH  - Colonic Neoplasms/genetics/metabolism/*pathology
MH  - Fatty Acid-Binding Proteins/genetics/*metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - Signal Transduction
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - Cancer proliferation
OT  - Colon cancer
OT  - Fatty acid binding protein 5
OT  - Hypoxia
OT  - Hypoxia-inducible factor-1 alpha
OT  - Three-dimensional cell culture
EDAT- 2021/11/15 06:00
MHDA- 2021/12/25 06:00
CRDT- 2021/11/14 21:03
PHST- 2021/03/11 00:00 [received]
PHST- 2021/10/14 00:00 [revised]
PHST- 2021/11/02 00:00 [accepted]
PHST- 2021/11/15 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/11/14 21:03 [entrez]
AID - S2210-7762(21)00220-9 [pii]
AID - 10.1016/j.cancergen.2021.11.001 [doi]
PST - ppublish
SO  - Cancer Genet. 2021 Nov;258-259:151-156. doi: 10.1016/j.cancergen.2021.11.001. 
      Epub 2021 Nov 5.