PMID- 34775620
OWN - NLM
STAT- MEDLINE
DCOM- 20220523
LR  - 20220523
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 102
IP  - 8
DP  - 2022 Jun
TI  - Intervention of 4% salmon phospholipid on metabolic syndrome in mice based on 
      colonic lipidomics analysis.
PG  - 3088-3098
LID - 10.1002/jsfa.11649 [doi]
AB  - BACKGROUND: The incidence of metabolic syndrome (MetS) is increasing, and n-3 
      polyunsaturated fatty acids (PUFAs) in salmon (Oncorhynchus) phospholipids can 
      effectively reduce the risk of MetS. RESULTS: Under the intervention of 4% salmon 
      phospholipid, the levels of fasting blood glucose (FBG), insulin, monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) and tumor necrosis 
      factor-alpha (TNF-alpha) were significantly reduced in the plasma of MetS mice, whereas 
      adiponectin was significantly increased. By screening, we found that the 18 
      differential metabolites, consisting of seven triglycerides (TGs), six 
      diglycerides (DGs), one phosphatidylethanolamine (PE), three sphingomyelins (SMs) 
      and one eicosanoid, could be the key differential metabolites, and two metabolic 
      pathways were significantly affected: glycerolipid metabolism and 
      glycerophospholipid metabolism. CONCLUSION: 4% salmon phospholipids could affect 
      MetS by inhibiting insulin resistance, reducing inflammatory factors and 
      promoting the synthesis of PE, yet the mechanism required further study. Our 
      results could help in the treatment of MetS. (c) 2021 Society of Chemical Industry.
CI  - (c) 2021 Society of Chemical Industry.
FAU - Cao, Hui
AU  - Cao H
AD  - Team of Neonatal and Infant Development, Health and Nutrition (NDHN), School of 
      Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, PR 
      China.
FAU - Chen, Shu-Fen
AU  - Chen SF
AD  - Team of Neonatal and Infant Development, Health and Nutrition (NDHN), School of 
      Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, PR 
      China.
FAU - Wang, Zi-Chen
AU  - Wang ZC
FAU - Dong, Xin-Jie
AU  - Dong XJ
AD  - Team of Neonatal and Infant Development, Health and Nutrition (NDHN), School of 
      Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, PR 
      China.
FAU - Wang, Ran-Ran
AU  - Wang RR
AD  - School of Food Engineering, Wuhan Polytechnic University, Wuhan, PR China.
FAU - Lin, Hong
AU  - Lin H
AD  - School of Food Engineering, Wuhan Polytechnic University, Wuhan, PR China.
FAU - Wang, Qi
AU  - Wang Q
AD  - School of Food Engineering, Wuhan Polytechnic University, Wuhan, PR China.
FAU - Zhao, Xiu-Ju
AU  - Zhao XJ
AUID- ORCID: 0000-0003-4962-6285
AD  - Team of Neonatal and Infant Development, Health and Nutrition (NDHN), School of 
      Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, PR 
      China.
LA  - eng
PT  - Journal Article
DEP - 20211203
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Phospholipids)
SB  - IM
MH  - Animals
MH  - *Insulin Resistance
MH  - Lipidomics
MH  - *Metabolic Syndrome/drug therapy
MH  - Mice
MH  - Phospholipids
MH  - Salmon
OTO - NOTNLM
OT  - colonic contents
OT  - metabolic syndrome
OT  - pseudotargeted lipidomics
OT  - salmon phospholipids
EDAT- 2021/11/15 06:00
MHDA- 2022/05/24 06:00
CRDT- 2021/11/14 21:18
PHST- 2021/11/11 00:00 [revised]
PHST- 2021/08/05 00:00 [received]
PHST- 2021/11/14 00:00 [accepted]
PHST- 2021/11/15 06:00 [pubmed]
PHST- 2022/05/24 06:00 [medline]
PHST- 2021/11/14 21:18 [entrez]
AID - 10.1002/jsfa.11649 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2022 Jun;102(8):3088-3098. doi: 10.1002/jsfa.11649. Epub 2021 
      Dec 3.