PMID- 34776310
OWN - NLM
STAT- MEDLINE
DCOM- 20211216
LR  - 20211216
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 373
IP  - Pt B
DP  - 2022 Mar 30
TI  - Endocrine disruptors on and in fruits and vegetables: Estimation of the potential 
      exposure of the French population.
PG  - 131513
LID - S0308-8146(21)02519-X [pii]
LID - 10.1016/j.foodchem.2021.131513 [doi]
AB  - Fruits and vegetables are considered to be healthy compared to fats, 
      carbohydrates, and meats. However, their production involves plant protection 
      products (PPPs) or they can contain phytoestrogens which may exhibit endocrine 
      effects. Thus, the exposure to the main PPPs and to phytoestrogens known as 
      endocrine disruptors (EDs) is estimated. PPPs include fungicides, growth 
      substances, herbicides, and insecticides authorised in France. ED-PPPs exposure 
      is estimated from the maximum residue limits (MRLs) of 70 potential ED-PPPs used 
      in France on 64 fruits and vegetables. The estimated exposure to potential 
      ED-PPPs is 509 microg/d and involves agonist and antagonist substances in complex 
      mixtures. Anti-androgens are preeminent, at 353 microg/d. Exposure to genistein and 
      daidzein is calculated from 140 measurements in 9 categories of food-items 
      containing soy. The global exposure to isoflavones in France is evaluated at 
      6700 microg/d. Phytoestrogen exposure is much higher than that of ED-PPPs. Their 
      endocrine effects should be considered.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Lee, Alexandre
AU  - Lee A
AD  - University of Bordeaux, 33070 Bordeaux France; Bordeaux Sciences Agro, 33175 
      Gradignan France.
FAU - Bensaada, Souad
AU  - Bensaada S
AD  - University of Bordeaux, 33070 Bordeaux France; U1212 Inserm, UMR Inserm U1212, 
      CNRS 5320, University of Bordeaux, 33070 Bordeaux France.
FAU - Lamothe, Valerie
AU  - Lamothe V
AD  - University of Bordeaux, 33070 Bordeaux France; Bordeaux Sciences Agro, 33175 
      Gradignan France.
FAU - Lacoste, Melissa
AU  - Lacoste M
AD  - University of Bordeaux, 33070 Bordeaux France; Bordeaux Sciences Agro, 33175 
      Gradignan France.
FAU - Bennetau-Pelissero, Catherine
AU  - Bennetau-Pelissero C
AD  - University of Bordeaux, 33070 Bordeaux France; Bordeaux Sciences Agro, 33175 
      Gradignan France; U1212 Inserm, UMR Inserm U1212, CNRS 5320, University of 
      Bordeaux, 33070 Bordeaux France. Electronic address: 
      catherine.bennetau@u-bordeaux.fr.
LA  - eng
PT  - Journal Article
DEP - 20211101
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Isoflavones)
RN  - 0 (Phytoestrogens)
RN  - DH2M523P0H (Genistein)
SB  - IM
MH  - *Endocrine Disruptors
MH  - Fruit/chemistry
MH  - Genistein
MH  - *Isoflavones
MH  - Phytoestrogens/analysis
MH  - Vegetables
OTO - NOTNLM
OT  - Consumer exposure
OT  - Endocrine disruptors
OT  - Isoflavones
OT  - Maximum residue limits
OT  - Plant protection products
EDAT- 2021/11/16 06:00
MHDA- 2021/12/17 06:00
CRDT- 2021/11/15 05:51
PHST- 2021/05/28 00:00 [received]
PHST- 2021/10/25 00:00 [revised]
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/12/17 06:00 [medline]
PHST- 2021/11/15 05:51 [entrez]
AID - S0308-8146(21)02519-X [pii]
AID - 10.1016/j.foodchem.2021.131513 [doi]
PST - ppublish
SO  - Food Chem. 2022 Mar 30;373(Pt B):131513. doi: 10.1016/j.foodchem.2021.131513. 
      Epub 2021 Nov 1.