PMID- 34776455
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211206
IS  - 1674-8301 (Print)
IS  - 2352-4685 (Electronic)
IS  - 1674-8301 (Linking)
VI  - 35
IP  - 6
DP  - 2021 Jul 30
TI  - Isometric exercise promotes arteriogenesis in rats after myocardial infarction.
PG  - 436-447
LID - 10.7555/JBR.35.20210062 [doi]
AB  - Isometric exercise (IE) is a promising intervention of noninvasive 
      revascularization in patients with acute myocardial infarction (AMI). This study 
      aimed to investigate the impact and mechanisms of IE training on arteriogenesis 
      in AMI. Male Sprague-Dawley rats were randomly assigned into the sham-operation 
      group (SO), myocardial infarction (MI) group, and 13 IE subgroups treated 
      according to training intensity, frequency, duration, or monocyte chemoattractant 
      protein-1 (MCP-1), or/and fibroblast growth factor-2 (FGF-2) inhibitors for eight 
      weeks. Our results demonstrated that the IE group achieved superior improvement 
      compared with the MI group in terms of left ventricular ejection fraction (LVEF), 
      myocardial infarction size (MIS), arterial density (AD), monocytes (MNCs), smooth 
      muscle cells (SMCs), endothelial cells (ECs), relative collateral blood flow 
      (RCBF), MCP-1, and FGF-2 at the endpoint. Positive correlations between MCP-1 and 
      MNCs, MNCs and FGF-2, FGF-2 and SMCs, SMCs and AD, as well as AD and RCBF were 
      observed. This study demonstrated that with MI of 100% load 20 times daily for 
      eight weeks, the arteriogenesis was improved, which may be attributed to the 
      recruitment of MNCs and SMCs in remote ischemic myocardium caused by increases in 
      MCP-1 and FGF-2 expression.
FAU - Zhang, Xintong
AU  - Zhang X
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Zheng, Yu
AU  - Zheng Y
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Geng, Canru
AU  - Geng C
AD  - Department of Rehabilitation Medicine, the Affiliated Suzhou Hospital of Nanjing 
      Medical University, Suzhou, Jiangsu 215000, China.
FAU - Guan, Juntao
AU  - Guan J
AD  - Department of Rehabilitation Medicine, the Affiliated Suzhou Hospital of Nanjing 
      Medical University, Suzhou, Jiangsu 215000, China.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Zhang, Xiu
AU  - Zhang X
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Cheng, Yihui
AU  - Cheng Y
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Li, Jian'an
AU  - Li J
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
FAU - Lu, Xiao
AU  - Lu X
AD  - Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, Jiangsu 210029, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Biomed Res
JT  - Journal of biomedical research
JID - 101551157
PMC - PMC8637657
OTO - NOTNLM
OT  - acute myocardial infarction
OT  - arteriogenesis
OT  - fibroblast growth factor-2
OT  - isometric exercise training
OT  - monocyte chemoattractant protein-1
COIS- The authors reported no conflict of interests.
EDAT- 2021/11/16 06:00
MHDA- 2021/11/16 06:01
PMCR- 2021/11/01
CRDT- 2021/11/15 06:46
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/11/16 06:01 [medline]
PHST- 2021/11/15 06:46 [entrez]
PHST- 2021/11/01 00:00 [pmc-release]
AID - jbr-35-6-436 [pii]
AID - 10.7555/JBR.35.20210062 [doi]
PST - ppublish
SO  - J Biomed Res. 2021 Jul 30;35(6):436-447. doi: 10.7555/JBR.35.20210062.