PMID- 34776850
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211117
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 15
DP  - 2021
TI  - Altered Spontaneous Brain Activity Patterns and Functional Connectivity in Adults 
      With Intermittent Exotropia: A Resting-State fMRI Study.
PG  - 746882
LID - 10.3389/fnins.2021.746882 [doi]
LID - 746882
AB  - The purpose of this study is to investigate brain functional changes in patients 
      with intermittent exotropia (IXT) by analyzing the amplitude of low-frequency 
      fluctuation (ALFF) of brain activity and functional connectivity (FC) using 
      resting-state functional magnetic resonance imaging (rs-fMRI). There were 26 IXT 
      patients and 22 age-, sex-, education-, and handedness-matched healthy controls 
      (HCs) enrolled who underwent rs-fMRI. The ALFF, fractional ALFF (fALFF) values in 
      the slow 4 and slow 5 bands, and FC values were calculated and compared. The 
      correlations between ALFF/fALFF values in discrepant brain regions and clinical 
      features were evaluated. Compared with HCs, ALFF/fALFF values were significantly 
      increased in the right angular gyrus (ANG), supramarginal gyrus (SMG), inferior 
      parietal lobule (IPL), precentral gyrus (PreCG), and the bilateral inferior 
      frontal gyri (IFG), and decreased in the right precuneus gyrus (PCUN), left 
      middle occipital gyrus (MOG), and postcentral gyrus (PoCG) in IXT patients. The 
      Newcastle Control Test score was negatively correlated with ALFF values in the 
      right IFG (r = -0.738, p < 0.001). The duration of IXT was negatively correlated 
      with ALFF values in the right ANG (r = -0.457, p = 0.049). Widespread increases 
      in FC were observed between brain regions, mainly including the right cuneus 
      (CUN), left superior parietal lobule (SPL), right rolandic operculum (ROL), left 
      middle temporal gyrus (MTG), left IFG, left median cingulate gyrus (DCG), left 
      PoCG, right PreCG, and left paracentral gyrus (PCL) in patients with IXT. No 
      decreased FC was observed. Patients with IXT exhibited aberrant intrinsic brain 
      activities and FC in vision- and eye movement-related brain regions, which extend 
      current understanding of the neuropathological mechanisms underlying visual and 
      oculomotor impairments in IXT patients.
CI  - Copyright (c) 2021 He, Hong, Wang, Guo, Li, Qu, Liu, Li, Zhang, Fu and Liu.
FAU - He, Xueying
AU  - He X
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Hong, Jie
AU  - Hong J
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Guo, Yanan
AU  - Guo Y
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Li, Ting
AU  - Li T
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Qu, Xiaoxia
AU  - Qu X
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Zhang, Lirong
AU  - Zhang L
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
FAU - Fu, Jing
AU  - Fu J
AD  - Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical 
      University, Beijing, China.
FAU - Liu, Zhaohui
AU  - Liu Z
AD  - Department of Radiology, Beijing Tongren Hospital, Capital Medical University, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211029
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC8586526
OTO - NOTNLM
OT  - amplitude of low-frequency fluctuations
OT  - functional connectivity
OT  - intermittent exotropia
OT  - resting-state functional MRI
OT  - spontaneous activity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/16 06:00
MHDA- 2021/11/16 06:01
PMCR- 2021/01/01
CRDT- 2021/11/15 06:55
PHST- 2021/07/25 00:00 [received]
PHST- 2021/09/29 00:00 [accepted]
PHST- 2021/11/15 06:55 [entrez]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/11/16 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2021.746882 [doi]
PST - epublish
SO  - Front Neurosci. 2021 Oct 29;15:746882. doi: 10.3389/fnins.2021.746882. 
      eCollection 2021.