PMID- 34776902 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211117 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 15 DP - 2021 TI - Ipsilesional Mu Rhythm Desynchronization Correlates With Improvements in Affected Hand Grip Strength and Functional Connectivity in Sensorimotor Cortices Following BCI-FES Intervention for Upper Extremity in Stroke Survivors. PG - 725645 LID - 10.3389/fnhum.2021.725645 [doi] LID - 725645 AB - Stroke is a leading cause of acquired long-term upper extremity motor disability. Current standard of care trajectories fail to deliver sufficient motor rehabilitation to stroke survivors. Recent research suggests that use of brain-computer interface (BCI) devices improves motor function in stroke survivors, regardless of stroke severity and chronicity, and may induce and/or facilitate neuroplastic changes associated with motor rehabilitation. The present sub analyses of ongoing crossover-controlled trial NCT02098265 examine first whether, during movements of the affected hand compared to rest, ipsilesional Mu rhythm desynchronization of cerebral cortical sensorimotor areas [Brodmann's areas (BA) 1-7] is localized and tracks with changes in grip force strength. Secondly, we test the hypothesis that BCI intervention results in changes in frequency-specific directional flow of information transmission (direct path functional connectivity) in BA 1-7 by measuring changes in isolated effective coherence (iCoh) between cerebral cortical sensorimotor areas thought to relate to electrophysiological signatures of motor actions and motor learning. A sample of 16 stroke survivors with right hemisphere lesions (left hand motor impairment), received a maximum of 18-30 h of BCI intervention. Electroencephalograms were recorded during intervention sessions while outcome measures of motor function and capacity were assessed at baseline and completion of intervention. Greater desynchronization of Mu rhythm, during movements of the impaired hand compared to rest, were primarily localized to ipsilesional sensorimotor cortices (BA 1-7). In addition, increased Mu desynchronization in the ipsilesional primary motor cortex, Post vs. Pre BCI intervention, correlated significantly with improvements in hand function as assessed by grip force measurements. Moreover, the results show a significant change in the direction of causal information flow, as measured by iCoh, toward the ipsilesional motor (BA 4) and ipsilesional premotor cortices (BA 6) during BCI intervention. Significant iCoh increases from ipsilesional BA 4 to ipsilesional BA 6 were observed in both Mu [8-12 Hz] and Beta [18-26 Hz] frequency ranges. In summary, the present results are indicative of improvements in motor capacity and behavior, and they are consistent with the view that BCI-FES intervention improves functional motor capacity of the ipsilesional hemisphere and the impaired hand. CI - Copyright (c) 2021 Remsik, Gjini, Williams, van Kan, Gloe, Bjorklund, Rivera, Romero, Young, Nair, Caldera, Williams and Prabhakaran. FAU - Remsik, Alexander B AU - Remsik AB AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Institute for Clinical and Translational Research, University of Wisconsin-Madison, Madison, WI, United States. FAU - Gjini, Klevest AU - Gjini K AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Neurology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Williams, Leroy Jr AU - Williams L Jr AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Educational Psychology, University of Wisconsin-Madison, Madison, WI, United States. AD - Center for Women's Health Research, University of Wisconsin-Madison, Madison, WI, United States. FAU - van Kan, Peter L E AU - van Kan PLE AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. FAU - Gloe, Shawna AU - Gloe S AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Bjorklund, Erik AU - Bjorklund E AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Clinical Neuroengineering Training Program, University of Wisconsin-Madison, Madison, WI, United States. FAU - Rivera, Cameron A AU - Rivera CA AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Romero, Sophia AU - Romero S AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Young, Brittany M AU - Young BM AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. AD - Clinical Neuroengineering Training Program, University of Wisconsin-Madison, Madison, WI, United States. AD - Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. FAU - Nair, Veena A AU - Nair VA AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Caldera, Kristin E AU - Caldera KE AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Williams, Justin C AU - Williams JC AD - Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, United States. FAU - Prabhakaran, Vivek AU - Prabhakaran V AD - Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Neurology, University of Wisconsin-Madison, Madison, WI, United States. AD - Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. AD - Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States. AD - Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States. AD - Department of Psychology, University of Wisconsin-Madison, Madison, WI, United States. LA - eng GR - T32 GM008692/GM/NIGMS NIH HHS/United States GR - T32 GM140935/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20211028 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC8581197 OTO - NOTNLM OT - Beta OT - Mu OT - brain-computer interface OT - iCoh OT - motor function OT - sensorimotor rhythm OT - stroke COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/11/16 06:00 MHDA- 2021/11/16 06:01 PMCR- 2021/01/01 CRDT- 2021/11/15 06:56 PHST- 2021/06/15 00:00 [received] PHST- 2021/10/01 00:00 [accepted] PHST- 2021/11/15 06:56 [entrez] PHST- 2021/11/16 06:00 [pubmed] PHST- 2021/11/16 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fnhum.2021.725645 [doi] PST - epublish SO - Front Hum Neurosci. 2021 Oct 28;15:725645. doi: 10.3389/fnhum.2021.725645. eCollection 2021.