PMID- 34777188
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211117
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 12
DP  - 2021
TI  - Comparing Brain Functional Activities in Patients With Blepharospasm and Dry Eye 
      Disease Measured With Resting-State fMRI.
PG  - 607476
LID - 10.3389/fneur.2021.607476 [doi]
LID - 607476
AB  - Background: Blepharospasm (BSP) and dry eye disease (DED) are clinically common 
      diseases characterized by an increased blinking rate. A sustained eyelid muscle 
      activity may alter the cortical sensorimotor concordance and lead to secondary 
      functional changes. This study aimed to explore the central mechanism of BSP by 
      assessing brain functional differences between the two groups and comparing them 
      with healthy controls. Methods: In this study, 25 patients with BSP, 22 patients 
      with DED, and 23 healthy controls underwent resting-state functional magnetic 
      resonance imaging (fMRI) scan. The amplitude of low-frequency fluctuations (ALFF) 
      was applied to analyze the imaging data. Results: Analysis of covariance (ANCOVA) 
      revealed widespread differences in ALFF across the three groups. In comparison 
      with healthy controls, patients with BSP showed abnormal ALFF in the sensorimotor 
      integration related-brain regions, including the bilateral supplementary motor 
      area (SMA), left cerebellar Crus I, left fusiform gyrus, bilateral superior 
      medial prefrontal cortex (MPFC), and right superior frontal gyrus (SFG). In 
      comparison with patients with DED, patients with BSP exhibited a significantly 
      increased ALFF in the left cerebellar Crus I and left SMA. ALFF in the left 
      fusiform gyrus/cerebellar Crus I was positively correlated with symptomatic 
      severity of BSP. Conclusions: Our results reveal that the distinctive changes in 
      the brain function in patients with BSP are different from those in patients with 
      DED and healthy controls. The results further emphasize the primary role of 
      sensorimotor integration in the pathophysiology of BSP.
CI  - Copyright (c) 2021 Feng, Jiang, Xiao, Liu, Pang, Liang, Tang, Lu, Wei, Li, Lei, Guo 
      and Luo.
FAU - Feng, Changqiang
AU  - Feng C
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Jiang, Wenyan
AU  - Jiang W
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Xiao, Yousheng
AU  - Xiao Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Pang, Lulu
AU  - Pang L
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Liang, Meilan
AU  - Liang M
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Tang, Jingqun
AU  - Tang J
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Lu, Yulin
AU  - Lu Y
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Wei, Jing
AU  - Wei J
AD  - Department of Comprehensive Internal Medicine, Guangxi Medical University 
      Affiliated Tumor Hospital, Nanning, China.
FAU - Li, Wenmei
AU  - Li W
AD  - Department of Radiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Lei, Yiwu
AU  - Lei Y
AD  - Department of Radiology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Guo, Wenbin
AU  - Guo W
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital of Central South University, Changsha, China.
FAU - Luo, Shuguang
AU  - Luo S
AD  - Department of Neurology, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
LA  - eng
PT  - Journal Article
DEP - 20211027
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC8578056
OTO - NOTNLM
OT  - amplitude of low-frequency fluctuations
OT  - blepharospasm
OT  - dry eye disease
OT  - functional magnetic resonance imaging
OT  - sensorimotor integration
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/16 06:00
MHDA- 2021/11/16 06:01
PMCR- 2021/10/27
CRDT- 2021/11/15 06:57
PHST- 2020/09/26 00:00 [received]
PHST- 2021/09/24 00:00 [accepted]
PHST- 2021/11/15 06:57 [entrez]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/11/16 06:01 [medline]
PHST- 2021/10/27 00:00 [pmc-release]
AID - 10.3389/fneur.2021.607476 [doi]
PST - epublish
SO  - Front Neurol. 2021 Oct 27;12:607476. doi: 10.3389/fneur.2021.607476. eCollection 
      2021.