PMID- 34777252
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Spatial Analysis of Incidence of Diagnosed Type 2 Diabetes Mellitus and Its 
      Association With Obesity and Physical Inactivity.
PG  - 755575
LID - 10.3389/fendo.2021.755575 [doi]
LID - 755575
AB  - OBJECTIVES: To investigate the spatial distribution of 10-year incidence of 
      diagnosed type 2 diabetes mellitus (T2DM) and its association with obesity and 
      physical inactivity at a reginal level breakdown. METHODS: Demographic, 
      behavioral, medical and pharmaceutical and diagnosed T2DM incidence data were 
      collected from a cohort of 232,064 participants who were free of diabetes at 
      enrolment in the 45 and Up Study, conducted in the state of New South Wales 
      (NSW), Australia. We examined the geographical trend and correlation between 
      obesity prevalence, physical inactivity rate and age-and-gender-adjusted 
      cumulative incidence of T2DM, aggregated based on geographical regions. RESULT: 
      The T2DM incidence, prevalence of obesity and physical inactivity rate at 
      baseline were 6.32%, 20.24%, and 18.7%, respectively. The spatial variation of 
      T2DM incidence was significant (Moran's I=0.52; p<0.01), with the lowest 
      incidence of 2.76% in Richmond Valley-Coastal and the highest of 12.27% in Mount 
      Druitt. T2DM incidence was significantly correlated with the prevalence of 
      obesity (Spearman r=0.62, p<0.001), percentage of participants having five 
      sessions of physical activities or less per week (r=0.79, p<0.001) and percentage 
      of participants walked to work (r=-0.44, p<0.001). The geographical variations in 
      obesity prevalence and physical inactivity rate resembled the geographical 
      variation in the incidence of T2DM. CONCLUSION: The spatial distribution of T2DM 
      incidence is significantly associated with the geographical prevalence of obesity 
      and physical inactivity rate. Regional campaigns advocating the importance of 
      physical activities in response to the alarming T2DM epidemic should be promoted.
CI  - Copyright (c) 2021 Wu, Wang, Xiao, Shang, He and Zhang.
FAU - Wu, Jinrong
AU  - Wu J
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
AD  - Research Centre for Data Analytics and Cognition, La Trobe University, Melbourne, 
      VIC, Australia.
FAU - Wang, Yang
AU  - Wang Y
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
FAU - Xiao, Xin
AU  - Xiao X
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
AD  - Center for Optometry and Visual Science, Department of Optometry, People's 
      Hospital of Guangxi Zhuang Autonomous Region, Guangxi, China.
FAU - Shang, Xianwen
AU  - Shang X
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
FAU - He, Mingguang
AU  - He M
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
AD  - Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, VIC, 
      Australia.
AD  - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen 
      University, Guangzhou, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 
      Melbourne, VIC, Australia.
AD  - Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
AD  - Central Clinical School, Faculty of Medicine, Monash University, Melbourne, VIC, 
      Australia.
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211028
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - New South Wales/epidemiology
MH  - Obesity/*complications
MH  - *Sedentary Behavior
MH  - *Spatial Analysis
PMC - PMC8581298
OTO - NOTNLM
OT  - Australian
OT  - GIS
OT  - diabetes
OT  - incidence
OT  - obesity
OT  - physical inactivity
OT  - risk factors
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/16 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/01/01
CRDT- 2021/11/15 06:58
PHST- 2021/08/09 00:00 [received]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/11/15 06:58 [entrez]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.755575 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Oct 28;12:755575. doi: 
      10.3389/fendo.2021.755575. eCollection 2021.