PMID- 34777523
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240404
IS  - 1728-1997 (Print)
IS  - 2252-0589 (Electronic)
IS  - 2252-0589 (Linking)
VI  - 22
IP  - 3
DP  - 2021 Summer
TI  - The anti-proliferative and apoptotic effects of curcumin on feline mammary gland 
      tumor cells in vitro.
PG  - 222-229
LID - 10.22099/ijvr.2021.40452.5866 [doi]
AB  - BACKGROUND: Feline mammary gland tumors (FMGTs) are the third most diagnosed 
      tumors in cats. Feline mammary gland tumors have aggressive biological behavior 
      and poor response to both surgical and medical treatments, thus, new therapeutic 
      approaches are essential to improve. Curcumin (CUR) is a polyphenol component 
      exhibiting anti-cancer effects and induces apoptosis through different mechanisms 
      especially in human breast cancer. However, there is no study investigating the 
      effects of CUR on FMGTs. AIMS: The aim of this study was to determine the 
      anti-proliferative and apoptotic effects of CUR on primary cell lines from FMGT 
      tissue samples of two cases classified as carcinoma-simple, tubular type (grade 
      III). METHODS: The cytotoxic effect of CUR was determined by water-soluble 
      tetrazolium salt-1 (WST-1) assay. Annexin V, cell cycle, and acridine orange (AO) 
      analyses were performed to determine the apoptotic effect of CUR. RESULTS: Our 
      results showed that CUR had an anti-proliferative and apoptotic effect through 
      induction of apoptosis and cell cycle arrest (G0/G1) on FMGT cells. CONCLUSION: 
      Therefore, this is the first study that shows the effects of CUR on FMGTs. 
      However, further molecular studies are required to compare the effects of CUR on 
      different histopathological phenotypes and to determine the further molecular 
      mechanisms including the potential apoptotic and cellular pathways affected by 
      CUR.
FAU - Deveci Ozkan, A
AU  - Deveci Ozkan A
AD  - Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, 
      Turkey.
FAU - Guney Eskiler, G
AU  - Guney Eskiler G
AD  - Department of Medical Biology, Faculty of Medicine, Sakarya University, Sakarya, 
      Turkey.
FAU - Turna, O
AU  - Turna O
AD  - Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, 
      Istanbul University-Cerrahpasa, Istanbul, Turkey.
FAU - Kazan, N
AU  - Kazan N
AD  - MSc Student in Medical Biology, Department of Medical Biology, Institute of 
      Health Science, Sakarya University, Sakarya, Turkey.
FAU - Sozen Kucukkara, E
AU  - Sozen Kucukkara E
AD  - Ph.D. Student in Biochemistry, Department of Medical Biochemistry, Institute of 
      Health Science, Sakarya University, Sakarya, Turkey.
FAU - Baykal, A
AU  - Baykal A
AD  - Ph.D. Student in Gynecology, Department of Obstetrics and Gynecology, Faculty of 
      Veterinary Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
FAU - Sonmez, K
AU  - Sonmez K
AD  - Department of Pathology, Faculty of Veterinary Medicine, Istanbul 
      University-Cerrahpasa, Istanbul, Turkey.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Vet Res
JT  - Iranian journal of veterinary research
JID - 101660030
PMC - PMC8573394
OTO - NOTNLM
OT  - Apoptosis
OT  - Cell cycle
OT  - Curcumin
OT  - Feline mammary gland tumor
COIS- The authors declare that there is no conflict of interest.
EDAT- 2021/11/16 06:00
MHDA- 2021/11/16 06:01
PMCR- 2021/06/01
CRDT- 2021/11/15 06:59
PHST- 2021/04/24 00:00 [received]
PHST- 2021/05/28 00:00 [revised]
PHST- 2021/06/07 00:00 [accepted]
PHST- 2021/11/15 06:59 [entrez]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/11/16 06:01 [medline]
PHST- 2021/06/01 00:00 [pmc-release]
AID - 10.22099/ijvr.2021.40452.5866 [doi]
PST - ppublish
SO  - Iran J Vet Res. 2021 Summer;22(3):222-229. doi: 10.22099/ijvr.2021.40452.5866.