PMID- 34780490 OWN - NLM STAT- MEDLINE DCOM- 20211222 LR - 20231108 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 16 IP - 11 DP - 2021 TI - Brain structures and activity during a working memory task associated with internet addiction tendency in young adults: A large sample study. PG - e0259259 LID - 10.1371/journal.pone.0259259 [doi] LID - e0259259 AB - The structural and functional brain characteristics associated with the excessive use of the internet have attracted substantial research attention in the past decade. In current study, we used voxel-based morphometry (VBM) and multiple regression analysis to assess the relationship between internet addiction tendency (IAT) score and regional gray and white matter volumes (rGMVs and rWMVs) and brain activity during a WM task in a large sample of healthy young adults (n = 1,154, mean age, 20.71 +/- 1.78 years). We found a significant positive correlation between IAT score and gray matter volume (GMV) of right supramarginal gyrus (rSMG) and significant negative correlations with white matter volume (WMV) of right temporal lobe (sub-gyral and superior temporal gyrus), right sublobar area (extra-nuclear and lentiform nucleus), right cerebellar anterior lobe, cerebellar tonsil, right frontal lobe (inferior frontal gyrus and sub-gyral areas), and the pons. Also, IAT was significantly and positively correlated with brain activity in the default-mode network (DMN), medial frontal gyrus, medial part of the superior frontal gyrus, and anterior cingulate cortex during a 2-back working memory (WM) task. Moreover, whole-brain analyses of rGMV showed significant effects of interaction between sex and the IAT scores in the area spreading around the left anterior insula and left lentiform. This interaction was moderated by positive correlation in women. These results indicate that IAT is associated with (a) increased GMV in rSMG, which is involved in phonological processing, (b) decreased WMV in areas of frontal, sublobar, and temporal lobes, which are involved in response inhibition, and (c) reduced task-induced deactivation of the DMN, indicative of altered attentional allocation. FAU - Sadeghi, Saeid AU - Sadeghi S AUID- ORCID: 0000-0002-2922-6412 AD - Institute for Cognitive and Brain Sciences (ICBS), Shahid Beheshti University, Tehran, Iran. AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Center of Excellence in Cognitive Neuropsychology, Shahid Beheshti University, Tehran, Iran. FAU - Takeuchi, Hikaru AU - Takeuchi H AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Shalani, Bita AU - Shalani B AD - Department of Psychology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. FAU - Taki, Yasuyuki AU - Taki Y AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. AD - Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Nouchi, Rui AU - Nouchi R AD - Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan. AD - Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan. AD - Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Yokoyama, Ryoichi AU - Yokoyama R AD - School of Medicine, Kobe University, Kobe, Japan. FAU - Kotozaki, Yuka AU - Kotozaki Y AD - Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan. FAU - Nakagawa, Seishu AU - Nakagawa S AD - Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Department of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai, Japan. FAU - Sekiguchi, Atsushi AU - Sekiguchi A AD - Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan. AD - Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan. FAU - Iizuka, Kunio AU - Iizuka K AD - Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan. FAU - Hanawa, Sugiko AU - Hanawa S AD - Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Araki, Tsuyoshi AU - Araki T AD - ADVANTAGE Risk Management Co., Ltd., Tokyo, Japan. FAU - Miyauchi, Carlos Makoto AU - Miyauchi CM AD - Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Sakaki, Kohei AU - Sakaki K AD - Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Nozawa, Takayuki AU - Nozawa T AUID- ORCID: 0000-0001-6300-4373 AD - Research Center for the Earth Inclusive Sensing Empathizing with Silent Voices, Tokyo Institute of Technology, Tokyo, Japan. AD - Graduate School of Arts and Sciences, Department of General Systems Studies, The University of Tokyo, Tokyo, Japan. FAU - Ikeda, Shigeyuki AU - Ikeda S AD - Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Yokota, Susumu AU - Yokota S AD - Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University, Fukuoka, Japan. FAU - Magistro, Daniele AU - Magistro D AUID- ORCID: 0000-0002-2554-3701 AD - Department of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom. FAU - Sassa, Yuko AU - Sassa Y AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. FAU - Kawashima, Ryuta AU - Kawashima R AD - Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. AD - Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211115 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Humans MH - *Internet Addiction Disorder MH - Memory, Short-Term PMC - PMC8592411 COIS- The authors declare no competing financial or non-financial interests. EDAT- 2021/11/16 06:00 MHDA- 2021/12/24 06:00 PMCR- 2021/11/15 CRDT- 2021/11/15 17:19 PHST- 2021/03/25 00:00 [received] PHST- 2021/10/15 00:00 [accepted] PHST- 2021/11/15 17:19 [entrez] PHST- 2021/11/16 06:00 [pubmed] PHST- 2021/12/24 06:00 [medline] PHST- 2021/11/15 00:00 [pmc-release] AID - PONE-D-21-09795 [pii] AID - 10.1371/journal.pone.0259259 [doi] PST - epublish SO - PLoS One. 2021 Nov 15;16(11):e0259259. doi: 10.1371/journal.pone.0259259. eCollection 2021.