PMID- 34781065
OWN - NLM
STAT- MEDLINE
DCOM- 20220401
LR  - 20220401
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 149
DP  - 2022 Feb
TI  - 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin potential impacts on peripheral blood 
      mononuclear cells of endometriosis women.
PG  - 103439
LID - S0165-0378(21)00169-8 [pii]
LID - 10.1016/j.jri.2021.103439 [doi]
AB  - Endometriosis happens following the implantation of endometrial-derived tissues 
      outside the uterine cavity. It has been suggested that 2, 3, 7, 
      8-Tetrachlorodibenzo-p-dioxin (TCDD) is involved in endometriosis development. 
      Furthermore, aryl hydrocarbon receptor (AHR), as a TCDD receptor, has been 
      demonstrated to regulate immune responses. Nonetheless, data regarding the 
      mechanisms, through which TCDD influences the immune system in endometriosis, are 
      still inconclusive. Therefore, frequency of regulatory T cells (Tregs) and the 
      expression of FOXP3, AHR and indoleamine 2, 3-dioxygenase 1 (IDO1) from 
      endometriosis and non-endometriosis individuals were investigated in the absence 
      and presence of TCDD; also, the concentration of IL-6 and kynurenine in the 
      supernatant of cultures was assessed. The impact of TCDD-treated PBMCs on the 
      migration capacity of menstrual blood-derived stromal stem cells (MenSCs) and 
      monocyte chemoattractant protein-1 (MCP-1) and IL-6 production was determined. 
      Here, we found that AHR and IDO1 expression levels were lower in endometriosis 
      PBMCs; however, TCDD treatment increased AHR, FOXP3, IDO1, IL-6, and Treg levels 
      in the endometriosis group (P </= 0.05-0.0001). TCDD-treated PBMCs increased the 
      migration capacity of MenSCs and up-regulated MCP-1 and IL-6 levels in the 
      PBMCs/MenSCs co-culture (P </= 0.01-0.0001). In conclusion, these results shed 
      light on the probable mechanisms, through which AHR activation by chemical 
      toxicants can impact inflammatory immune mediators involved in the development of 
      endometriosis; also, these data support the idea that TCDD could promote 
      endometriosis progression.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Tanha, Mahsa
AU  - Tanha M
AD  - Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran; 
      Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Bozorgmehr, Mahmood
AU  - Bozorgmehr M
AD  - Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Shokri, Mohammad-Reza
AU  - Shokri MR
AD  - Department of Immunology, School of Public Health, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Edalatkhah, Haleh
AU  - Edalatkhah H
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran.
FAU - Tanha, Mahya
AU  - Tanha M
AD  - Faculty of Pharmacy, Eastern Mediterranean University, Via Mersin-10, Famagusta, 
      North Cyprus, Turkey.
FAU - Zarnani, Amir-Hassan
AU  - Zarnani AH
AD  - Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, 
      Tehran, Iran; Department of Immunology, School of Public Health, Tehran 
      University of Medical Sciences, Tehran, Iran. Electronic address: 
      zarnania@sina.tums.ac.ir.
FAU - Nikoo, Shohreh
AU  - Nikoo S
AD  - Immunology Research Center (IRC), Iran University of Medical Sciences, Tehran, 
      Iran. Electronic address: sh_nikoo2000@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20211029
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (AHR protein, human)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - 343-65-7 (Kynurenine)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cells, Cultured
MH  - Coculture Techniques
MH  - Endometriosis/metabolism
MH  - Female
MH  - Humans
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism
MH  - Kynurenine/metabolism
MH  - Leukocytes
MH  - Leukocytes, Mononuclear/metabolism
MH  - Polychlorinated Dibenzodioxins/*metabolism
MH  - Receptors, Aryl Hydrocarbon/metabolism
MH  - Stromal Cells/metabolism
MH  - T-Lymphocytes, Regulatory/immunology
OTO - NOTNLM
OT  - 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)
OT  - Aryl hydrocarbon receptor (AHR)
OT  - Endometriosis
OT  - Indoleamine 2, 3-dioxygenase 1 (IDO1)
OT  - Regulatory T cells (Tregs)
EDAT- 2021/11/16 06:00
MHDA- 2022/04/02 06:00
CRDT- 2021/11/15 20:17
PHST- 2021/04/11 00:00 [received]
PHST- 2021/08/22 00:00 [revised]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2022/04/02 06:00 [medline]
PHST- 2021/11/15 20:17 [entrez]
AID - S0165-0378(21)00169-8 [pii]
AID - 10.1016/j.jri.2021.103439 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2022 Feb;149:103439. doi: 10.1016/j.jri.2021.103439. Epub 2021 
      Oct 29.