PMID- 34781130
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 228
DP  - 2021 Nov 12
TI  - Prenatal exposure to bisphenols and risk of preterm birth: Findings from Guangxi 
      Zhuang birth cohort in China.
PG  - 112960
LID - S0147-6513(21)01072-1 [pii]
LID - 10.1016/j.ecoenv.2021.112960 [doi]
AB  - Preterm birth (PTB), a serious adverse birth outcome, is the leading cause of 
      perinatal mortality and morbidity. Bisphenols induce endocrine disruption that 
      spreads across the placenta, which may affect fetal growth and development. 
      However, the effects of bisphenols on PTB, particularly their combined effects, 
      remain unknown. This study investigated the association between prenatal 
      bisphenol exposure and PTB. Study participants were 2023 mother-infant pairs that 
      were selected from the Guangxi Zhuang Birth Cohort. Maternal serum bisphenol 
      levels were measured using ultrahigh performance liquid chromatography-tandem 
      mass spectrometry, and pregnancy outcomes were obtained from medical records. 
      Multivariate logistic regression, restricted cubic spline, principal component 
      analysis (PCA), quantile g-computation (Qgcomp), and Bayesian kernel machine 
      regression (BKMR) were used to examine the association between serum bisphenol 
      levels and PTB. Ln-transformed BPA concentrations were associated with an 
      increased risk of PTB only in female infants (OR = 1.30, 95% CI: 1.02, 1.64). 
      Ln-transformed bisphenol F (BPF) concentrations were positively associated with 
      the risk of PTB (OR = 1.73, 95% CI: 1.18, 2.55). Inverse U-shaped relationships 
      were observed between bisphenol B (BPB), bisphenol S (BPS), and 
      tetrabromobisphenol A (TBBPA) levels and the risk of PTB (P-overall < 0.05, 
      P-non-linear < 0.05). After sex stratification, the association between BPA 
      analogs and PTB was only observed in males. In Qgcomp analysis, bisphenol 
      mixtures were related to an increased risk of PTB (OR = 1.52, 95% CI: 1.04, 
      2.21), with BPF (43.7%), BPS (29.6%) and BPA (26.8%) having the greatest positive 
      contribution. Results indicate that prenatal exposure to bisphenol mixtures might 
      increase the risk of PTB, which might be primarily driven by BPA, BPF and BPS. 
      There may also be sex-specific and nonmonotonic dose-dependent effects.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Yang, Chunxiu
AU  - Yang C
AD  - The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 
      530021, China.
FAU - Liu, Tao
AU  - Liu T
AD  - Huaihua Center for Disease Control and Prevention, Huaihua 418000, Hunan, China.
FAU - Tan, Hui Juan Jennifer
AU  - Tan HJJ
AD  - Ngee Ann Polytechnic, School of Life Sciences & Chemical Technology, 535 Clementi 
      Rd, Singapore 599489, Singapore.
FAU - Sheng, Yonghong
AU  - Sheng Y
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Wei, Liangjia
AU  - Wei L
AD  - School of Laboratory Medicine, Youjiang Medical University for Nationalities, 
      Baise 533000, Guangxi, China.
FAU - Tang, Peng
AU  - Tang P
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Huang, Huishen
AU  - Huang H
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Zeng, Xiaoyun
AU  - Zeng X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China.
FAU - Liu, Shun
AU  - Liu S
AD  - Department of Child and Adolescent Health & Maternal and Child Health, School of 
      Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. 
      Electronic address: liushun@gxmu.edu.cn.
FAU - Huang, Dongping
AU  - Huang D
AD  - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical 
      University, Nanning 530021, Guangxi, China. Electronic address: 
      dongpinghuang@gxmu.edu.cn.
FAU - Qiu, Xiaoqiang
AU  - Qiu X
AD  - Department of Epidemiology and Health Statistics, School of Public Health, 
      Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address: 
      xqqiu9999@163.com.
LA  - eng
PT  - Journal Article
DEP - 20211112
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
OTO - NOTNLM
OT  - Bisphenols
OT  - Maternal serum
OT  - Newborns
OT  - Preterm birth
EDAT- 2021/11/16 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/11/15 20:21
PHST- 2021/08/05 00:00 [received]
PHST- 2021/10/28 00:00 [revised]
PHST- 2021/10/31 00:00 [accepted]
PHST- 2021/11/16 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/11/15 20:21 [entrez]
AID - S0147-6513(21)01072-1 [pii]
AID - 10.1016/j.ecoenv.2021.112960 [doi]
PST - aheadofprint
SO  - Ecotoxicol Environ Saf. 2021 Nov 12;228:112960. doi: 
      10.1016/j.ecoenv.2021.112960.