PMID- 34781133 OWN - NLM STAT- Publisher LR - 20240220 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 228 DP - 2021 Nov 12 TI - Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China. PG - 112976 LID - S0147-6513(21)01088-5 [pii] LID - 10.1016/j.ecoenv.2021.112976 [doi] AB - Many metals are involved in the pathogenesis of diabetes, but most of existing studies focused on single metals. The study of mixtures represents real-life exposure scenarios and deserves attention. This study aimed to explore the potential relationship of urinary copper (Cu), zinc (Zn), arsenic (As), selenium (Se), and strontium (Sr) contents with fasting plasma glucose (FPG) levels in 2766 participants. The levels of metals in urine were determined by inductively coupled plasma-mass spectrometry. We used linear regression models and the Bayesian kernel machine regression (BKMR) to evaluate the association between metals and FPG levels. In the multiple metals linear regression, Zn (beta = 0.434), Se (beta = 0.172), and Sr (beta = -0.143) showed significant association with FPG levels (all P < 0.05). The BKMR model analysis showed that the results of single metal association were consistent with the multiple metals linear regression. The mixture of five metals had a positive over-all effect on FPG levels, and Zn (PIP = 1.000) contributed the most to the FPG levels. Cu and As were negatively correlated with FPG levels in women. The potential interaction effect between Cu and Sr was observed in participants aged >/= 60 years old (P(interaction) = 0.035). In summary, our results suggested that multiple metals in urine are associated with FPG levels. Further studies are needed to confirm these findings and clarify the underlying mechanisms. CI - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Mo, Xiaoting AU - Mo X AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Cai, Jiansheng AU - Cai J AD - Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, Guangxi, China. FAU - Lin, Yinxia AU - Lin Y AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Liu, Qiumei AU - Liu Q AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Xu, Min AU - Xu M AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Zhang, Junling AU - Zhang J AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Liu, Shuzhen AU - Liu S AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Wei, Chunmei AU - Wei C AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Wei, Yanfei AU - Wei Y AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Huang, Shenxiang AU - Huang S AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Mai, Tingyu AU - Mai T AD - Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China. FAU - Tan, Dechan AU - Tan D AD - Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China. FAU - Lu, Huaxiang AU - Lu H AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Luo, Tingyu AU - Luo T AD - Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China. FAU - Gou, Ruoyu AU - Gou R AD - Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China. FAU - Zhang, Zhiyong AU - Zhang Z AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China; Department of Environmental Health and Occupational Medicine, School of Public Health, Guilin Medical University, Guilin 541004, Guangxi, China. Electronic address: rpazz@163.com. FAU - Qin, Jian AU - Qin J AD - Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address: qinjian@gxmu.edu.cn. LA - eng PT - Journal Article DEP - 20211112 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 SB - IM OTO - NOTNLM OT - Bayesian kernel machine regression OT - Diabetes OT - Fasting plasma glucose OT - Urinary metal EDAT- 2021/11/16 06:00 MHDA- 2021/11/16 06:00 CRDT- 2021/11/15 20:21 PHST- 2021/08/11 00:00 [received] PHST- 2021/11/02 00:00 [revised] PHST- 2021/11/05 00:00 [accepted] PHST- 2021/11/16 06:00 [pubmed] PHST- 2021/11/16 06:00 [medline] PHST- 2021/11/15 20:21 [entrez] AID - S0147-6513(21)01088-5 [pii] AID - 10.1016/j.ecoenv.2021.112976 [doi] PST - aheadofprint SO - Ecotoxicol Environ Saf. 2021 Nov 12;228:112976. doi: 10.1016/j.ecoenv.2021.112976.