PMID- 34782548
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220716
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 24
IP  - 3
DP  - 2022 May-Jun
TI  - Association of sexually transmitted infection with semen quality in men from 
      couples with primary and secondary infertility.
PG  - 317-322
LID - 10.4103/aja202164 [doi]
AB  - This study aims to compare the prevalence of sexually transmitted infections 
      (STIs) with semen quality in men from couples with primary and secondary 
      infertility. Semen samples were collected from 133 men who requested fertility 
      evaluation. Seminal tract infection with Ureaplasma spp. (UU), Mycoplasma hominis 
      (MH), Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), Neisseria 
      gonorrhoeae (NG), and herpes simplex virus-2 (HSV-2) was assessed by PCR-based 
      diagnostic assays. Among all patients, the prevalence of STIs was higher in men 
      from couples with primary infertility than that in men from couples with 
      secondary infertility (39.7% vs 21.7%, P = 0.03). The prevalence of UU was 28.8% 
      and 13.3% in men from couples with primary and secondary infertility, 
      respectively. Men from couples with primary infertility were more likely to be 
      positive for UU than men from couples with secondary infertility (P = 0.04). 
      Regarding the UU subtype, the prevalence of Ureaplasma urealyticum (Uuu) and 
      Ureaplasma parvum (Uup; including Uup1, Uup3, Uup6, and Uup14) did not differ 
      between the two groups. No associations between the prevalence rates of MH, MG, 
      and CT were found in men from either infertility group. A lower sperm 
      concentration was associated with STI pathogen positivity in men with primary 
      infertility according to the crude model (P = 0.04). The crude and adjusted 
      models showed that semen volume (both P = 0.03) and semen leukocyte count (both P 
      = 0.02) were independently associated with secondary infertility. These findings 
      suggest the importance of classifying the type of infertility during routine 
      diagnosis of seminal tract infections.
FAU - Bai, Shun
AU  - Bai S
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
FAU - Li, Yuan
AU  - Li Y
AD  - Dermatology Department, The Fifth People's Hospital of Hainan Province, Haikou 
      570100, China.
FAU - Hu, Mei-Hong
AU  - Hu MH
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
FAU - Wu, Li
AU  - Wu L
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
FAU - Shui, Li-Jun
AU  - Shui LJ
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
FAU - Wang, Xiao-Han
AU  - Wang XH
AD  - Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China.
FAU - Liu, Yi-Xun
AU  - Liu YX
AD  - Department of Urology, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Hefei 
      230001, China.
FAU - Yue, Qiu-Ling
AU  - Yue QL
AD  - Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, Nanjing 210008, China.
FAU - Yu, Li-Na
AU  - Yu LN
AD  - Reproductive Medicine Center, The Affiliated Drum Tower Hospital of Nanjing 
      University Medical School, Nanjing 210008, China.
FAU - Fu, Kai-Qiang
AU  - Fu KQ
AD  - College of Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, 
      China.
FAU - Tong, Xian-Hong
AU  - Tong XH
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
FAU - Hu, Xue-Chun
AU  - Hu XC
AD  - Department of Urology, The First Affiliated Hospital of USTC, Division of Life 
      Sciences and Medicine, University of Science and Technology of China, Hefei 
      230001, China.
FAU - Xu, Bo
AU  - Xu B
AD  - Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, 
      Division of Life Sciences and Medicine, University of Science and Technology of 
      China, Hefei 230001, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
SB  - IM
MH  - Female
MH  - Humans
MH  - *Infertility, Male/epidemiology
MH  - Male
MH  - *Mycoplasma genitalium
MH  - Mycoplasma hominis
MH  - Prevalence
MH  - Semen
MH  - Semen Analysis
MH  - *Sexually Transmitted Diseases/complications/epidemiology
MH  - Ureaplasma urealyticum
PMC - PMC9226702
OTO - NOTNLM
OT  - primary infertility
OT  - secondary infertility
OT  - semen parameters
OT  - sexually transmitted infections
COIS- None
EDAT- 2021/11/17 06:00
MHDA- 2022/05/12 06:00
PMCR- 2021/09/21
CRDT- 2021/11/16 06:14
PHST- 2021/11/17 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2021/11/16 06:14 [entrez]
PHST- 2021/09/21 00:00 [pmc-release]
AID - 326366 [pii]
AID - AJA-24-317 [pii]
AID - 10.4103/aja202164 [doi]
PST - ppublish
SO  - Asian J Androl. 2022 May-Jun;24(3):317-322. doi: 10.4103/aja202164.