PMID- 34783376
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1522-2594 (Electronic)
IS  - 0740-3194 (Linking)
VI  - 87
IP  - 3
DP  - 2022 Mar
TI  - Assessment of measurement precision in single-voxel spectroscopy at 7 T: Toward 
      minimal detectable changes of metabolite concentrations in the human brain in 
      vivo.
PG  - 1119-1135
LID - 10.1002/mrm.29034 [doi]
AB  - PURPOSE: To introduce a study design and statistical analysis framework to assess 
      the repeatability, reproducibility, and minimal detectable changes (MDCs) of 
      metabolite concentrations determined by in vivo MRS. METHODS: An unbalanced 
      nested study design was chosen to acquire in vivo MRS data within different 
      repeatability and reproducibility scenarios. A spin-echo, full-intensity acquired 
      localized (SPECIAL) sequence was employed at 7 T utlizing three different 
      inversion pulses: a hyperbolic secant (HS), a gradient offset independent 
      adiabaticity (GOIA), and a wideband, uniform rate, smooth truncation (WURST) 
      pulse. Metabolite concentrations, Cramer-Rao lower bounds (CRLBs) and 
      coefficients of variation (CVs) were calculated. Both Bland-Altman analysis and a 
      restricted maximum-likelihood estimation (REML) analysis were performed to 
      estimate the different variance contributions of the repeatability and 
      reproducibility of the measured concentration. A Bland-Altmann analysis of the 
      spectral shape was performed to assess the variance of the spectral shape, 
      independent of quantification model influences. RESULTS: For the used setup, 
      minimal detectable changes of brain metabolite concentrations were found to be 
      between 0.40 micromol/g and 2.23 micromol/g. CRLBs account for only 16 % to 74 % of the 
      total variance of the metabolite concentrations. The application of 
      gradient-modulated inversion pulses in SPECIAL led to slightly improved 
      repeatability, but overall reproducibility appeared to be limited by differences 
      in positioning, calibration, and other day-to-day variations throughout different 
      sessions. CONCLUSION: A framework is introduced to estimate the precision of 
      metabolite concentrations obtained by MRS in vivo, and the minimal detectable 
      changes for 13 metabolite concentrations measured at 7 T using SPECIAL are 
      obtained.
CI  - (c) 2021 Physikalisch-Technische Bundesanstalt Berlin. Magnetic Resonance in 
      Medicine published by Wiley Periodicals LLC on behalf of International Society 
      for Magnetic Resonance in Medicine.
FAU - Riemann, Layla Tabea
AU  - Riemann LT
AUID- ORCID: 0000-0001-5411-7288
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
FAU - Aigner, Christoph Stefan
AU  - Aigner CS
AUID- ORCID: 0000-0003-3618-9610
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
FAU - Ellison, Stephen L R
AU  - Ellison SLR
AUID- ORCID: 0000-0002-3008-6656
AD  - LGC Limited, Teddington Middx, United Kingdom.
FAU - Bruhl, Rudiger
AU  - Bruhl R
AUID- ORCID: 0000-0003-0111-5996
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
FAU - Mekle, Ralf
AU  - Mekle R
AUID- ORCID: 0000-0001-6821-7722
AD  - Center for Stroke Research Berlin, Charite-Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Schmitter, Sebastian
AU  - Schmitter S
AUID- ORCID: 0000-0003-4410-6790
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
FAU - Speck, Oliver
AU  - Speck O
AUID- ORCID: 0000-0002-6019-5597
AD  - Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany.
AD  - Research Campus STIMULATE, Magdeburg, Germany.
FAU - Rose, Georg
AU  - Rose G
AUID- ORCID: 0000-0002-2215-150X
AD  - Research Campus STIMULATE, Magdeburg, Germany.
AD  - Institut fur Medizintechnik, Otto-von-Guericke University, Magdeburg, Germany.
FAU - Ittermann, Bernd
AU  - Ittermann B
AUID- ORCID: 0000-0002-4087-471X
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
FAU - Fillmer, Ariane
AU  - Fillmer A
AUID- ORCID: 0000-0003-3333-6603
AD  - Physikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211116
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
SB  - IM
MH  - *Brain/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Spectroscopy
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - CRLBs
OT  - MR spectroscopy
OT  - SPECIAL
OT  - measurement precision
OT  - minimal detectable change
OT  - reproducibility/repeatability
EDAT- 2021/11/17 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/11/16 09:13
PHST- 2021/09/14 00:00 [revised]
PHST- 2021/05/01 00:00 [received]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/11/17 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/11/16 09:13 [entrez]
AID - 10.1002/mrm.29034 [doi]
PST - ppublish
SO  - Magn Reson Med. 2022 Mar;87(3):1119-1135. doi: 10.1002/mrm.29034. Epub 2021 Nov 
      16.