PMID- 34783930
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220223
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Print)
IS  - 1569-5794 (Linking)
VI  - 38
IP  - 1
DP  - 2022 Jan
TI  - Development of a nomogram for predicting the risk of left ventricular diastolic 
      function in subjects with type-2 diabetes mellitus.
PG  - 15-23
LID - 10.1007/s10554-021-02338-5 [doi]
AB  - Left ventricular diastolic dysfunction (LVDD) can be affected by many factors, 
      including epicardial adipose tissue (EAT), obesity and type-2 diabetes mellitus 
      (T2DM). The aim of this study was to establish and validate an easy-to-use 
      nomogram that predicts the severity of LVDD in patients with T2DM. This is a 
      retrospective study of 84 consecutive subjects with T2DM admitted to the 
      Endocrinology Department, the First People's Hospital of Zunyi City between 
      January 2015 and October 2020. Several echocardiographic characteristics were 
      used to diagnose diastolic dysfunction according to the 2016 diastolic 
      dysfunction ASE guidelines. Anthropometric, demographic, and biochemical 
      parameters were collected. Through a least absolute shrinkage and selection 
      operator (LASSO) regression model, we reduced the dimensionality of the data and 
      determined factors for the nomogram. The mean follow-up was 25.97 months. Cases 
      were divided into two groups, those with LVDD (31) and those without (53). LASSO 
      regression identified total cholesterol (Tol.chol), low-density lipoprotein 
      (LDL), right ventricular anterior wall (RVAW) and epicardial adipose tissue (EAT) 
      were identified as predictive factors in the nomogram. The ROC curve analysis 
      demonstrated that the AUC value for most clinical paramerters was higher than 
      0.6. The nomogram can be used to promote the individualized prediction of LVDD 
      risk in T2DM patients, and help to prioritize patients diagnosed with 
      echocardiography.
CI  - (c) 2021. The Author(s).
FAU - Chen, Yuan
AU  - Chen Y
AD  - Department of Endocrinology, The First People's Hospital of Zunyi, The Third 
      Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
FAU - Yu, Meng
AU  - Yu M
AD  - Department of Endocrinology, The First People's Hospital of Zunyi, The Third 
      Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
FAU - Lan, Yalin
AU  - Lan Y
AD  - Department of Endocrinology, The First People's Hospital of Zunyi, The Third 
      Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
FAU - Feng, Fei
AU  - Feng F
AD  - Department of Endocrinology, The First People's Hospital of Zunyi, The Third 
      Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.
FAU - Jiang, Chengyan
AU  - Jiang C
AD  - Department of Endocrinology, The First People's Hospital of Zunyi, The Third 
      Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China. 
      jcydr700301@163.com.
LA  - eng
GR  - S2017JP00401149774/Natural Science Foundation of Guizhou/
PT  - Journal Article
DEP - 20211116
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Nomograms
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Ventricular Dysfunction, Left/diagnostic imaging/etiology
MH  - Ventricular Function, Left
PMC - PMC8818641
OTO - NOTNLM
OT  - Diastolic function
OT  - Epicardial fat
OT  - Left ventricular
OT  - Type-2 diabetes mellitus
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2021/11/17 06:00
MHDA- 2022/02/09 06:00
PMCR- 2021/11/16
CRDT- 2021/11/16 12:28
PHST- 2021/03/05 00:00 [received]
PHST- 2021/07/02 00:00 [accepted]
PHST- 2021/11/17 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2021/11/16 12:28 [entrez]
PHST- 2021/11/16 00:00 [pmc-release]
AID - 10.1007/s10554-021-02338-5 [pii]
AID - 2338 [pii]
AID - 10.1007/s10554-021-02338-5 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2022 Jan;38(1):15-23. doi: 10.1007/s10554-021-02338-5. 
      Epub 2021 Nov 16.