PMID- 34784620
OWN - NLM
STAT- MEDLINE
DCOM- 20220815
LR  - 20220815
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 130
IP  - 8
DP  - 2022 Aug
TI  - Shear Wave Elastography Reveals a High Prevalence of NAFLD-related Fibrosis even 
      in Type 1 Diabetes.
PG  - 532-538
LID - 10.1055/a-1666-0431 [doi]
AB  - BACKGROUND: The association between type 2 diabetes mellitus (T2DM) and advanced 
      stages of non-alcoholic fatty liver disease is well known. Some studies indicate 
      a relevant prevalence also in type 1 diabetes mellitus (T1DM), but so far there 
      is only limited data. OBJECTIVE: To determine the prevalence of non-alcoholic 
      fatty liver disease (NAFLD)-related liver fibrosis in individuals with T1DM and 
      compare to those with type 2 diabetes. METHODS: Diabetic patients from a single 
      diabetes care centre were screened for liver fibrosis by sonographic shear wave 
      elastography (SWE). In addition, all patients received laboratory evaluation 
      including non-alcoholic fatty liver fibrosis score and Fibrosis-4 Index. RESULTS: 
      Three hundred and forty patients were included in the study, of these, 310 
      received SWE. Overall 254 patients (93 with type 1 and 161 with type 2 diabetes) 
      had reliable measurements and were included in the final analysis. In patients 
      with type 1 diabetes, the prevalence of NAFLD-related liver fibrosis was 16-21%, 
      depending on the method of detection. Significant liver fibrosis was observed in 
      30-46% of patients with type 2 diabetes. CONCLUSIONS: Our data revealed an 
      unexpectedly high prevalence of NAFLD-related liver fibrosis in patients with 
      type 1 diabetes. To our knowledge, this is one of the first studies using SWE to 
      diagnose advanced NAFLD in type 1 diabetes in a non-preselected cohort. 
      Considering the findings of our study, regular screening for hepatic 
      complications must be recommended for all diabetic patients, even for those with 
      type 1 diabetes.
CI  - Thieme. All rights reserved.
FAU - Meyer, Gesine
AU  - Meyer G
AD  - Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany.
FAU - Dauth, Nina
AU  - Dauth N
AD  - Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany.
FAU - Grimm, Matthias
AU  - Grimm M
AD  - Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany.
FAU - Herrmann, Eva
AU  - Herrmann E
AD  - Institute of Biostatistics and Mathematic Modelling, Goethe-University, 
      Frankfurt, Germany.
FAU - Bojunga, Joerg
AU  - Bojunga J
AD  - Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany.
FAU - Friedrich-Rust, Mireen
AU  - Friedrich-Rust M
AD  - Department of Internal Medicine, Goethe-University Hospital, Frankfurt, Germany.
LA  - eng
PT  - Journal Article
DEP - 20211116
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
SB  - IM
MH  - *Diabetes Mellitus, Type 1/complications/diagnostic imaging/epidemiology
MH  - *Diabetes Mellitus, Type 2/complications/diagnostic imaging/epidemiology
MH  - *Elasticity Imaging Techniques/methods
MH  - Humans
MH  - Liver Cirrhosis/diagnostic imaging/epidemiology
MH  - *Non-alcoholic Fatty Liver Disease/complications/diagnostic imaging/epidemiology
MH  - Prevalence
COIS- The authors declare that they have no conflicts of interest that could be 
      perceived as prejudicing the impartiality of the research reported.
EDAT- 2021/11/17 06:00
MHDA- 2022/08/16 06:00
CRDT- 2021/11/16 20:12
PHST- 2021/11/17 06:00 [pubmed]
PHST- 2022/08/16 06:00 [medline]
PHST- 2021/11/16 20:12 [entrez]
AID - 10.1055/a-1666-0431 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2022 Aug;130(8):532-538. doi: 10.1055/a-1666-0431. 
      Epub 2021 Nov 16.