PMID- 34785097
OWN - NLM
STAT- MEDLINE
DCOM- 20220411
LR  - 20220411
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 83
IP  - 4
DP  - 2022 Apr
TI  - Different immunoregulatory components at the decidua basalis of oocyte donation 
      pregnancies.
PG  - 319-327
LID - S0198-8859(21)00253-6 [pii]
LID - 10.1016/j.humimm.2021.10.008 [doi]
AB  - Oocyte donation (OD) pregnancies are characterized by more fetal-maternal human 
      leukocyte antigen (HLA) mismatches compared with naturally conceived (NC) and in 
      vitro fertilization (IVF) pregnancies. The maternal immune system has to cope 
      with greater immunogenetic dissimilarity, but involved immunoregulation remains 
      poorly understood. We examined whether the amount of regulatory T cells (Tregs) 
      and immunoregulatory cytokines in decidua basalis of OD pregnancies differs from 
      NC and IVF pregnancies. The cohort included 25 OD, 11 IVF and 16 NC placentas, 
      maternal peripheral blood, and umbilical cord blood of uncomplicated pregnancies. 
      Placenta slides were stained for FOXP3, IL-10, IL-6, gal-1, TGF-beta and Flt-1. 
      Semi-quantitative (FOXP3+ Tregs) and computerized analysis (cytokines) were 
      executed. The blood samples were typed for HLA class I and II to calculate 
      fetal-maternal HLA mismatches. The percentage of Tregs was significantly higher 
      in pregnancies with 4-6 HLA class I mismatches (n = 17), compared to 0-3 
      mismatches (n = 35; p = 0.04). Cytokine analysis showed significant differences 
      between OD, IVF and NC pregnancies. Flt-1 was significantly lower in pregnancies 
      with 4-6 HLA class I mismatches (p = 0.004), and in pregnancies with 6-10 HLA 
      mismatches in total (p = 0.024). This study suggests that immunoregulation at the 
      fetal-maternal interface in OD pregnancies with more fetal-maternal HLA 
      mismatches is altered.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - van Bentem, Kim
AU  - van Bentem K
AD  - Department of Obstetrics and Gynecology, Leiden University Medical Center, 
      Albinusdreef 2, 2333 ZA Leiden, the Netherlands. Electronic address: 
      K.van_Bentem@lumc.nl.
FAU - Bos, Manon
AU  - Bos M
AD  - Department of Obstetrics and Gynecology, Leiden University Medical Center, 
      Albinusdreef 2, 2333 ZA Leiden, the Netherlands; Department of Pathology, Leiden 
      University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
FAU - van der Keur, Carin
AU  - van der Keur C
AD  - Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 
      ZA Leiden, the Netherlands.
FAU - Kapsenberg, Hanneke
AU  - Kapsenberg H
AD  - Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 
      ZA Leiden, the Netherlands.
FAU - Lashley, Eileen
AU  - Lashley E
AD  - Department of Obstetrics and Gynecology, Leiden University Medical Center, 
      Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
FAU - Eikmans, Michael
AU  - Eikmans M
AD  - Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 
      ZA Leiden, the Netherlands.
FAU - van der Hoorn, Marie-Louise
AU  - van der Hoorn ML
AD  - Department of Obstetrics and Gynecology, Leiden University Medical Center, 
      Albinusdreef 2, 2333 ZA Leiden, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20211114
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Cytokines)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Cytokines
MH  - Decidua
MH  - Female
MH  - Fertilization in Vitro
MH  - Forkhead Transcription Factors
MH  - *HLA Antigens
MH  - Histocompatibility Antigens Class I
MH  - Histocompatibility Antigens Class II
MH  - Humans
MH  - *Oocyte Donation
MH  - Pregnancy
OTO - NOTNLM
OT  - Decidua basalis
OT  - HLA mismatches
OT  - Immunoregulatory cytokines
OT  - Oocyte donation pregnancy
OT  - Regulatory T cells
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/11/18 06:00
MHDA- 2022/04/12 06:00
CRDT- 2021/11/17 05:46
PHST- 2021/08/05 00:00 [received]
PHST- 2021/10/08 00:00 [revised]
PHST- 2021/10/31 00:00 [accepted]
PHST- 2021/11/18 06:00 [pubmed]
PHST- 2022/04/12 06:00 [medline]
PHST- 2021/11/17 05:46 [entrez]
AID - S0198-8859(21)00253-6 [pii]
AID - 10.1016/j.humimm.2021.10.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2022 Apr;83(4):319-327. doi: 10.1016/j.humimm.2021.10.008. Epub 2021 
      Nov 14.