PMID- 34785169
OWN - NLM
STAT- MEDLINE
DCOM- 20220425
LR  - 20230502
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 237
DP  - 2022 May
TI  - Persistent Hypertransmission Defects Detected on En Face Swept Source Optical 
      Computed Tomography Images Predict the Formation of Geographic Atrophy in 
      Age-Related Macular Degeneration.
PG  - 58-70
LID - S0002-9394(21)00577-8 [pii]
LID - 10.1016/j.ajo.2021.11.001 [doi]
AB  - PURPOSE: To determine whether persistent hypertransmission defects (hyperTDs), 
      previously shown to have a greatest linear dimension (GLD) >/=250 microm on en face 
      swept source OCT (SS-OCT) images, serve as a stand-alone early biomarker for the 
      future formation geographic atrophy (GA). DESIGN: Post hoc cohort study using a 
      subgroup of a prospective study. METHODS: Patients with intermediate age-related 
      macular degeneration (iAMD) underwent 6- x 6-mm SS-OCT raster scans at baseline 
      and during their follow-up period. En face images were generated using a slab 
      with segmentation boundaries positioned 64 microm to 400 microm beneath the Bruch's 
      membrane. Two graders independently evaluated all en face structural images for 
      the presence of hyperTDs with a GLD >/=250 microm and GA. RESULTS: A total of 190 eyes 
      were included with a mean +/- SD follow-up of 31 +/- 13.2 months. At baseline, 31 
      eyes (16%) had at least 1 hyperTD >/=250 microm, and 13 eyes (42%) progressed to GA. In 
      those eyes without a hyperTD >/=250 microm at baseline, 42 (26%) developed hyperTDs 
      >/=250 microm during their follow-up, and 11 eyes (7%) progressed to GA. At the last 
      available follow-up visit, 25 eyes (13%) progressed to GA and of these 25 eyes, a 
      prior hyperTD >/=250 microm was detected in 24 eyes before GA formed. A time-dependent 
      Cox-survival regression analysis estimated an 80-fold (95% CI, 10.7-614, P < 
      .001) increased risk of developing GA once a hyperTD >/=250 microm appeared. 
      CONCLUSIONS: Persistent hyperTDs detected on en face OCT images were shown to 
      serve as an early stand-alone OCT biomarker for the future formation of GA.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Laiginhas, Rita
AU  - Laiginhas R
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Shi, Yingying
AU  - Shi Y
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Shen, Mengxi
AU  - Shen M
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Jiang, Xiaoshuang
AU  - Jiang X
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Feuer, William
AU  - Feuer W
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Gregori, Giovanni
AU  - Gregori G
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA.
FAU - Rosenfeld, Philip J
AU  - Rosenfeld PJ
AD  - From the Department of Ophthalmology (R.L., Y.S., M.S., X.J., W.F., G.G., 
      P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of 
      Medicine, Miami, Florida, USA. Electronic address: prosenfeld@miami.edu.
LA  - eng
GR  - P30 EY014801/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20211113
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Cohort Studies
MH  - Fluorescein Angiography/methods
MH  - *Geographic Atrophy/diagnosis/etiology
MH  - Humans
MH  - *Macular Degeneration/diagnosis
MH  - Prospective Studies
MH  - Tomography, Optical Coherence/methods
PMC - PMC9035026
MID - NIHMS1756516
EDAT- 2021/11/18 06:00
MHDA- 2022/04/26 06:00
PMCR- 2023/05/01
CRDT- 2021/11/17 05:49
PHST- 2021/06/20 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2021/11/01 00:00 [accepted]
PHST- 2021/11/18 06:00 [pubmed]
PHST- 2022/04/26 06:00 [medline]
PHST- 2021/11/17 05:49 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - S0002-9394(21)00577-8 [pii]
AID - 10.1016/j.ajo.2021.11.001 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2022 May;237:58-70. doi: 10.1016/j.ajo.2021.11.001. Epub 2021 
      Nov 13.