PMID- 34786357
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2231-5047 (Print)
IS  - 2231-5128 (Electronic)
IS  - 2231-5047 (Linking)
VI  - 11
IP  - 2
DP  - 2021 Jul-Dec
TI  - Adjuvant Treatment of Gastric Cancer in the D2 Dissection Era: A Real-life 
      Experience from a Multicenter Retrospective Cohort Study.
PG  - 51-58
LID - 10.5005/jp-journals-10018-1343 [doi]
AB  - BACKGROUND: The role of radiotherapy in the adjuvant treatment of gastric cancer 
      (GC) remains to be elucidated. This study aimed to assess the additional benefit 
      of radiotherapy in the adjuvant treatment of GC. MATERIALS AND METHODS: In this 
      retrospective cohort study, we included 230 gastric adenocarcinoma patients who 
      underwent D2 dissection between January 2004 and December 2019. Patients without 
      R0 resection, who underwent metastasectomy at surgery, and treated with the 
      neoadjuvant treatment were excluded. The co-primary endpoints were overall 
      survival (OS) and disease-free survival (DFS). The secondary endpoints were the 
      locoregional and distant metastasis risk and adverse events (AEs) leading to 
      treatment discontinuation. RESULTS: One hundred and sixty-six and 64 patients 
      were included in the chemoradiotherapy (CRT) and chemotherapy (ChT) arms, 
      respectively. The median OS was 135.8 months [interquartile range (IQR): 
      99.4-172.2] and 97 months (IQR: 59.7-134.3) in the CRT and the ChT arms, 
      respectively. No statistical significance was observed between the arms in OS (p 
      = 0.3). Locoregional or distant recurrence rates were similar in each group. AEs 
      leading to treatment discontinuation were higher in the CRT arm than in the ChT 
      arm (13.2 vs 9.3%), and the difference between the arms was not statistically 
      significant (p = 0.4). CONCLUSION: In this real-life study, we established that 
      there was no additional benefit of RT in GC patients who underwent D2 dissection. 
      HOW TO CITE THIS ARTICLE: Yekeduz E, Dogan I, Birgi SD, et al. Adjuvant Treatment 
      of Gastric Cancer in the D2 Dissection Era: A Real-life Experience from a 
      Multicenter Retrospective Cohort Study. Euroasian J Hepato-Gastroenterol 
      2021;11(2):51-58.
CI  - Copyright (c) 2021; Jaypee Brothers Medical Publishers (P) Ltd.
FAU - Yekeduz, Emre
AU  - Yekeduz E
AUID- ORCID: 0000-0001-6819-5930
AD  - Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Dogan, Izzet
AU  - Dogan I
AD  - Department of Medical Oncology, Istanbul University Institute of Oncology, 
      Istanbul, Turkey.
FAU - Birgi, Sumerya D
AU  - Birgi SD
AD  - Department of Radiation Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Keskin, Metin
AU  - Keskin M
AD  - Department of General Surgery, Istanbul University Faculty of Medicine, Istanbul, 
      Turkey.
FAU - Karaman, Sule
AU  - Karaman S
AD  - Department of Radiation Oncology, Istanbul University Institute of Oncology, 
      Istanbul, Turkey.
FAU - Utkan, Gungor
AU  - Utkan G
AD  - Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Karabulut, Senem
AU  - Karabulut S
AD  - Department of Medical Oncology, Istanbul University Institute of Oncology, 
      Istanbul, Turkey.
FAU - Bayar, Sancar
AU  - Bayar S
AD  - Department of Surgical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Akbulut, Hakan
AU  - Akbulut H
AD  - Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Demirci, Salim
AU  - Demirci S
AD  - Department of Surgical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Akyurek, Serap
AU  - Akyurek S
AD  - Department of Radiation Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
FAU - Urun, Yuksel
AU  - Urun Y
AD  - Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, 
      Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Euroasian J Hepatogastroenterol
JT  - Euroasian journal of hepato-gastroenterology
JID - 101577625
PMC - PMC8566162
OTO - NOTNLM
OT  - Chemoradiation
OT  - Chemotherapy
OT  - Gastric cancer
COIS- Source of support: Nil Conflict of interest: None
EDAT- 2021/11/18 06:00
MHDA- 2021/11/18 06:01
PMCR- 2021/07/01
CRDT- 2021/11/17 06:56
PHST- 2021/11/17 06:56 [entrez]
PHST- 2021/11/18 06:00 [pubmed]
PHST- 2021/11/18 06:01 [medline]
PHST- 2021/07/01 00:00 [pmc-release]
AID - 10.5005/jp-journals-10018-1343 [doi]
PST - ppublish
SO  - Euroasian J Hepatogastroenterol. 2021 Jul-Dec;11(2):51-58. doi: 
      10.5005/jp-journals-10018-1343.