PMID- 34787798
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220612
IS  - 1724-6059 (Electronic)
IS  - 1121-8428 (Linking)
VI  - 35
IP  - 4
DP  - 2022 May
TI  - Oxidative stress and macrophage infiltration in IgA nephropathy.
PG  - 1101-1111
LID - 10.1007/s40620-021-01196-7 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the interactions among serum 
      levels of galactose-deficient IgA1 (Gd-IgA1), oxidative stress and macrophage 
      infiltration and their clinical correlates in patients with IgA Nephropathy 
      (IgAN). METHODS: A total of 47 patients with biopsy-proven primary IgAN, aged 
      between 16 and 79 years, with a follow-up period >/= 1 year or who showed 
      progression to end stage kidney disease (ESKD) regardless the duration of 
      follow-up were included. Study endpoint was the progression to ESKD. Serum 
      Gd-IgA1 and advanced oxidation protein product (AOPP) levels were measured using 
      ELISA assays. Kidney biopsies were evaluated according to the Oxford MEST-C 
      scoring, with C4d and CD68 staining. RESULTS: Seventeen patients (36%) 
      experienced ESKD during a median follow-up time of 6 years (IQR 3.7-7.5). Serum 
      AOPP levels were correlated with the intensity of glomerular C3 deposition 
      (r = 0.325, p = 0.026), glomerular (r = 0.423, p = 0.003) and interstitial 
      CD68 + cell count (r = 0.298, p = 0.042) and Gd-IgA1 levels (r = 0.289, 
      p = 0.049). Serum Gd-IgA1 levels were correlated with the intensity of C3 
      deposition (r = 0.447, p = 0.002). eGFR at biopsy (adjusted HR (aHR) 0.979 
      p = 0.011), and E score (aHR, 8.305, p = 0.001) were associated with progression 
      to ESKD in multivariate analysis. 5-year ESKD-free survival rate was 
      significantly lower in patients with higher E score compared to patients with E 
      score 0 [p = 0.021]. CONCLUSIONS: An increased number of macrophages in the 
      glomerular and tubulointerstitial area may play a role in oxidative stress and 
      complement system activation. Endocapillary hypercellularity is a predictive 
      factor for poor prognosis in IgAN.
CI  - (c) 2021. This is a U.S. government work and not under copyright protection in the 
      U.S.; foreign copyright protection may apply.
FAU - Caliskan, Yasar
AU  - Caliskan Y
AD  - Division of Nephrology, Saint Louis University School of Medicine, 3660 Vista 
      Ave, Saint Louis, MO, USA. yasar.caliskan@health.slu.edu.
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey. yasar.caliskan@health.slu.edu.
FAU - Demir, Erol
AU  - Demir E
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Karatay, Ecem
AU  - Karatay E
AD  - Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Ozluk, Yasemin
AU  - Ozluk Y
AD  - Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Mirioglu, Safak
AU  - Mirioglu S
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
AD  - Division of Nephrology, Bezmialem Vakif University School of Medicine, Istanbul, 
      Turkey.
FAU - Dirim, Ahmet Burak
AU  - Dirim AB
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Artan, Ayse Serra
AU  - Artan AS
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Usta Akgul, Sebahat
AU  - Usta Akgul S
AD  - Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Oto, Ozgur Akin
AU  - Oto OA
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Savran Oguz, Fatma
AU  - Savran Oguz F
AD  - Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Turkmen, Aydin
AU  - Turkmen A
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
FAU - Lentine, Krista L
AU  - Lentine KL
AD  - Division of Nephrology, Saint Louis University School of Medicine, 3660 Vista 
      Ave, Saint Louis, MO, USA.
FAU - Yazici, Halil
AU  - Yazici H
AD  - Division of Nephrology, Istanbul Faculty of Medicine, Istanbul University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20211116
PL  - Italy
TA  - J Nephrol
JT  - Journal of nephrology
JID - 9012268
RN  - 0 (Advanced Oxidation Protein Products)
RN  - 0 (Immunoglobulin A)
RN  - X2RN3Q8DNE (Galactose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Advanced Oxidation Protein Products
MH  - Aged
MH  - Female
MH  - Galactose
MH  - *Glomerulonephritis, IGA/pathology
MH  - Humans
MH  - Immunoglobulin A
MH  - Macrophages
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Young Adult
OTO - NOTNLM
OT  - IgA nephropathy
OT  - Inflammation
OT  - Kidney disease
OT  - Macrophages
OT  - Oxidative stress
EDAT- 2021/11/18 06:00
MHDA- 2022/05/18 06:00
CRDT- 2021/11/17 12:32
PHST- 2021/06/29 00:00 [received]
PHST- 2021/09/27 00:00 [accepted]
PHST- 2021/11/18 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2021/11/17 12:32 [entrez]
AID - 10.1007/s40620-021-01196-7 [pii]
AID - 10.1007/s40620-021-01196-7 [doi]
PST - ppublish
SO  - J Nephrol. 2022 May;35(4):1101-1111. doi: 10.1007/s40620-021-01196-7. Epub 2021 
      Nov 16.