PMID- 34788186
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1547-6901 (Electronic)
IS  - 1547-691X (Linking)
VI  - 18
IP  - 1
DP  - 2021 Dec
TI  - Renal tubular cell necroptosis: A novel mechanism of kidney damage in 
      trichloroethylene hypersensitivity syndrome mice.
PG  - 173-182
LID - 10.1080/1547691X.2021.2003486 [doi]
AB  - Trichloroethylene (TCE) hypersensitivity syndrome (THS), called occupational 
      medicamentosa-like dermatitis due to TCE (OMDT) in China, is a fatal occupational 
      disorder caused by TCE exposure. Visceral damage, including kidney injury, is one 
      of the major complications. Necroptosis is a regulated cell death form linked to 
      local inflammatory response. This study aimed to investigate whether renal cell 
      necroptosis was involved in TCE-induced kidney injury. A Balb/c mouse model of 
      TCE sensitization was utilized to study mechanisms of modulation of TCE-induced 
      renal necroptosis. Renal histology (using light and transmission electron 
      microscopy) and renal tubular impairment indexes, including alpha1-microglobulin 
      (alpha1-MG), and beta2-microglobulin (beta2-MG), were evaluated. In addition, tissue 
      expression of necroptosis-related proteins, including tumor necrosis factor 
      (TNF)-alpha, TNF receptor 1 (TNFR1), receptor-interacting protein kinase 3 (RIPK3), 
      p-RIK3, mixed lineage kinase domain-like protein (MLKL), and p-MLKL, were also 
      evaluated. The study here confirmed TCE sensitization caused damage to renal 
      tubules and renal tubular epithelial cell (RTEC) necroptosis. In mice treated 
      with R7050 (a specific TNFalpha antagonist), it was also seen that inhibition of TNFalpha 
      expression could effectively inhibit RTEC necroptosis and improve renal function 
      in the TCE-sensitized mice. Taken together, these results help to define a novel 
      mechanism by which RTEC necroptosis plays a key role in TCE-induced kidney 
      damage.
FAU - Wang, Yican
AU  - Wang Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Anhui Medical University, Hefei, PR China.
FAU - Huang, Meng
AU  - Huang M
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Anhui Medical University, Hefei, PR China.
FAU - Du, Xin
AU  - Du X
AD  - Department of Dermatology, The Second Hospital of Anhui Medical University, 
      Hefei, PR China.
FAU - Hong, Yiting
AU  - Hong Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Anhui Medical University, Hefei, PR China.
FAU - Huang, Liping
AU  - Huang L
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Anhui Medical University, Hefei, PR China.
FAU - Dai, Yuying
AU  - Dai Y
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Anhui Medical University, Hefei, PR China.
FAU - Wu, Qifeng
AU  - Wu Q
AD  - Poison Control Center, Guangdong Province Hospital for Occupational Disease 
      Prevention and Treatment, Guangzhou, PR China.
FAU - Wang, Feng
AU  - Wang F
AUID- ORCID: 0000-0001-7421-0025
AD  - Department of Dermatology, The Second Hospital of Anhui Medical University, 
      Hefei, PR China.
FAU - Zhu, Qixing
AU  - Zhu Q
AD  - Department of Dermatology, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, PR China.
AD  - Key Laboratory of Dermatology, Ministry of Education, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Immunotoxicol
JT  - Journal of immunotoxicology
JID - 101201960
RN  - 290YE8AR51 (Trichloroethylene)
SB  - IM
MH  - Animals
MH  - Epithelial Cells
MH  - Kidney/physiology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Necroptosis
MH  - *Trichloroethylene/toxicity
OTO - NOTNLM
OT  - Trichloroethylene hypersensitivity syndrome
OT  - necroptosis
OT  - renal tubular epithelial cell
OT  - trichloroethylene
OT  - tumor necrosis factor
EDAT- 2021/11/18 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/11/17 17:17
PHST- 2021/11/17 17:17 [entrez]
PHST- 2021/11/18 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
AID - 10.1080/1547691X.2021.2003486 [doi]
PST - ppublish
SO  - J Immunotoxicol. 2021 Dec;18(1):173-182. doi: 10.1080/1547691X.2021.2003486.