PMID- 34789800
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20240404
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Nov 17
TI  - Dietary quality indices modify the effects of apolipoprotein B polymorphisms on 
      biochemical and anthropometric factors in type 2 diabetes mellitus.
PG  - 22395
LID - 10.1038/s41598-021-01884-1 [doi]
LID - 22395
AB  - We tried to identify the interaction between dietary quality indices and 
      apolipoprotein B Ins/Del and EcoR1 polymorphisms on biochemical and 
      anthropometric factors in patients with type 2 diabetes mellitus (T2DM). This 
      cross-sectional study recruited 700 adults with T2DM in Tehran. The genotypes of 
      Ins/Del and EcoR1 single nucleotide polymorphisms (SNP) were explored via 
      polymerase chain reaction (PCR). Dietary quality index-international (DQI-I), 
      healthy eating index-2015 (HEI-2015) and dietary phytochemical index (DPI) were 
      calculated by semi-quantitative food frequency questionnaire (FFQ). In both crude 
      and adjusted model for confounding factors, we observed significant interactions 
      between DQI-I and Ins/Del SNP on leptin in and 8-iso-prostaglandin F2 alpha 
      (8-iso-PGF2alpha), DPI and EcoR1 SNP on total cholesterol (TC) and between Ins/Del 
      SNP and HEI-2015 on interleukin-18 (IL-18). Furthermore, in crude model there 
      were close to meaningful interactions between EcoR1 SNP and DQI-I on total 
      antioxidant capacity (TAC) and between EcoR1 SNP and HEI-2015 on serum leptin and 
      superoxide dismutase (SOD) levels. Our finding indicated that the association 
      between DQI-I, HEI-2015 and DPI with IL-18, TC, leptin and 8-iso-PGF2alpha in 
      patients with T2DM might be dependent on Ins/Del and EcoR1 variants in ApoB gene.
CI  - (c) 2021. The Author(s).
FAU - Karimi, Elmira
AU  - Karimi E
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Sotoudeh, Gity
AU  - Sotoudeh G
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Rafiee, Masoumeh
AU  - Rafiee M
AD  - Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran. masomeh.rafiei@gmail.com.
FAU - Koohdani, Fariba
AU  - Koohdani F
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran. 
      fkoohdani@tums.ac.ir.
AD  - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences 
      and Dietetics, Tehran University of Medical Sciences, PO Box 141556117, Tehran, 
      Iran. fkoohdani@tums.ac.ir.
LA  - eng
GR  - 20414/Tehran University of Medical Sciences and Health Services/
GR  - 20414/Tehran University of Medical Sciences and Health Services/
GR  - 20414/Tehran University of Medical Sciences and Health Services/
GR  - 20414/Tehran University of Medical Sciences and Health Services/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211117
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Apolipoproteins B)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Analysis of Variance
MH  - Apolipoproteins B/*genetics/metabolism
MH  - Biomarkers
MH  - *Body Weights and Measures
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/*metabolism
MH  - *Diet
MH  - Disease Susceptibility
MH  - Exercise
MH  - *Food Quality
MH  - Genotype
MH  - Humans
MH  - INDEL Mutation
MH  - *Polymorphism, Single Nucleotide
MH  - Public Health Surveillance
PMC - PMC8599687
COIS- The authors declare no competing interests.
EDAT- 2021/11/19 06:00
MHDA- 2022/02/01 06:00
PMCR- 2021/11/17
CRDT- 2021/11/18 06:34
PHST- 2021/04/24 00:00 [received]
PHST- 2021/10/27 00:00 [accepted]
PHST- 2021/11/18 06:34 [entrez]
PHST- 2021/11/19 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/11/17 00:00 [pmc-release]
AID - 10.1038/s41598-021-01884-1 [pii]
AID - 1884 [pii]
AID - 10.1038/s41598-021-01884-1 [doi]
PST - epublish
SO  - Sci Rep. 2021 Nov 17;11(1):22395. doi: 10.1038/s41598-021-01884-1.