PMID- 34790416
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231108
IS  - 2090-0422 (Print)
IS  - 2090-0430 (Electronic)
IS  - 2090-0430 (Linking)
VI  - 2021
DP  - 2021
TI  - Protective Effect of Hyperbaric Oxygen Treatment on Axon Degeneration after Acute 
      Motor Axonal Neuropathy.
PG  - 6627779
LID - 10.1155/2021/6627779 [doi]
LID - 6627779
AB  - OBJECTIVES: Acute motor axonal neuropathy (AMAN) is a disease that leads to acute 
      flaccid paralysis and may result from the binding of antibody and antigen to the 
      spinal cord. The objective of this study is to evaluate the protective effect of 
      hyperbaric oxygen treatment (HBOT) on axon degeneration of the spinal cord and 
      sciatic nerve of the AMAN model rabbit. Axonal degeneration was assessed by 
      evaluating glutathione (GSH) activity, interleukin-1beta (IL-1beta) expression, and 
      clinical and histopathological features. METHODS: Twenty-one New Zealand rabbits 
      were divided into three groups. The treatment group was exposed to 100% oxygen at 
      2.4 ATA 90 minutes for 10 days at a decompression rate of 2.9 pounds per square 
      inch/minute. GSH level was evaluated using an enzyme-linked immune-sorbent assay. 
      An expression of IL-1beta in the spinal cord was determined by immunohistochemistry. 
      Clinical appearances were done by motor scale and body weight. Histological 
      features observed neuronal swelling and inflammatory infiltration in the sagittal 
      lumbar region and the undulation of the longitudinal sciatic nerve. RESULTS: 
      Rabbits exposed to HBO had high GSH activity levels (p < 0.05) but unexpectedly 
      had high IL1beta expression (p > 0.05). In addition, the HBO-exposed rabbits had a 
      better degree of undulation, the size of neuronal swelling was smaller, the 
      number of macrophages was higher, and motor function was better than the AMAN 
      model rabbits (p < 0.05). CONCLUSIONS: These findings indicate that HBO therapy 
      can decrease axon degeneration by triggering GSH activity, increasing IL-1beta 
      level, and restoring tissues and motor status. In conclusion, HBO has a 
      protective effect on axon degeneration of the spinal cord and sciatic nerve of 
      the AMAN model rabbit.
CI  - Copyright (c) 2021 Ni Komang Sri Dewi Untari et al.
FAU - Sri Dewi Untari, Ni Komang
AU  - Sri Dewi Untari NK
AUID- ORCID: 0000-0003-4179-5498
AD  - Department of Hyperbaric, Drs. Med. Rijadi S. Phys. Naval Health Institute, 
      Surabaya, Indonesia.
AD  - Department of Neurology, Faculty of Medicine, Hang Tuah University, Surabaya, 
      Indonesia.
AD  - Department of Neurology, Dr. Ramelan Navy Hospital, Surabaya, Indonesia.
AD  - Hyperbaric Medicine, Basic Medical Science, Airlangga University, Surabaya, 
      Indonesia.
FAU - Kusumastuti, Kurnia
AU  - Kusumastuti K
AUID- ORCID: 0000-0001-9904-6866
AD  - Department of Neurology, Faculty of Medicine, Airlangga University, Surabaya, 
      Indonesia.
FAU - Suryokusumo, Guritno
AU  - Suryokusumo G
AUID- ORCID: 0000-0002-8546-7341
AD  - Department of Hyperbaric, Faculty of Medicine, Pembangunan Nasional University, 
      Jakarta, Indonesia.
FAU - Sudiana, I Ketut
AU  - Sudiana IK
AUID- ORCID: 0000-0003-0652-9362
AD  - Department of Pathology Anatomy, Faculty of Medicine, Airlangga University, 
      Surabaya, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20211108
PL  - United States
TA  - Autoimmune Dis
JT  - Autoimmune diseases
JID - 101546750
PMC - PMC8592739
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/11/19 06:00
MHDA- 2021/11/19 06:01
PMCR- 2021/11/08
CRDT- 2021/11/18 06:59
PHST- 2021/01/03 00:00 [received]
PHST- 2021/09/22 00:00 [revised]
PHST- 2021/10/04 00:00 [accepted]
PHST- 2021/11/18 06:59 [entrez]
PHST- 2021/11/19 06:00 [pubmed]
PHST- 2021/11/19 06:01 [medline]
PHST- 2021/11/08 00:00 [pmc-release]
AID - 10.1155/2021/6627779 [doi]
PST - epublish
SO  - Autoimmune Dis. 2021 Nov 8;2021:6627779. doi: 10.1155/2021/6627779. eCollection 
      2021.