PMID- 34791781 OWN - NLM STAT- MEDLINE DCOM- 20220314 LR - 20220722 IS - 1468-1293 (Electronic) IS - 1464-2662 (Print) IS - 1464-2662 (Linking) VI - 23 IP - 4 DP - 2022 Apr TI - Follicle-stimulating hormone in postmenopausal women living with HIV: a prevalence study. PG - 434-440 LID - 10.1111/hiv.13205 [doi] AB - OBJECTIVES: We examined follicle-stimulating hormone (FSH) levels in women living with HIV aged > 45 reporting >/= 12 months' amenorrhoea, and investigated correlation with menopausal symptoms. METHODS: A cross-sectional substudy of 85 women from the Positive Transitions through the Menopause (PRIME) Study who reported irregular periods at entry into the PRIME Study and >/= 12 months' amenorrhoea at recruitment into this substudy. Serum FSH was supplemented with clinical data and menopausal symptom assessment. Serum FSH > 30 mIU/mL was defined as consistent with postmenopausal status. Associations between FSH and menopausal symptom severity were assessed using Pearson's correlation and the Kruskal-Wallis test. RESULTS: Median age was 53 years [interquartile range (IQR): 51-55]; all were on antiretroviral therapy, three-quarters (n = 65) had a CD4 T-cell count > 500 cells/muL and 91.8% (n = 78) had an HIV viral load (VL) < 50 copies/mL. Median FSH was 65.9 mIU/mL (IQR: 49.1-78.6). Only four women (4.7%) had FSH /= 200 cells/muL, and one had viral load (VL) >/= 50 copies/mL. Median body mass index (BMI) was elevated compared with women with FSH > 30 mIU/mL (40.8 vs. 30.5 kg/m(2) ). Over a quarter (28.2%) reported severe menopausal symptoms, with no correlation between FSH and severity of menopausal symptoms (p = 0.21), or hot flushes (p = 0.37). CONCLUSIONS: Four women in this small substudy had low FSH despite being amenorrhoeic; all had BMI >/= 35 kg/m(2) . We found that 95% of women with HIV aged > 45 years reporting >/= 12 months' amenorrhoea had elevated FSH, suggesting that menopausal status can be ascertained from menstrual history alone in this group. CI - (c) 2021 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association. FAU - Tariq, Shema AU - Tariq S AUID- ORCID: 0000-0001-9802-7727 AD - UCL Institute for Global Health, London, UK. AD - Mortimer Market Centre, CNWL NHS Foundation Trust, London, UK. FAU - Okhai, Hajra AU - Okhai H AUID- ORCID: 0000-0002-0549-4914 AD - UCL Institute for Global Health, London, UK. AD - National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at UCL, London, UK. FAU - Severn, Abigail AU - Severn A AD - UCL Institute for Global Health, London, UK. FAU - Sabin, Caroline A AU - Sabin CA AUID- ORCID: 0000-0001-5173-2760 AD - UCL Institute for Global Health, London, UK. AD - National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at UCL, London, UK. FAU - Burns, Fiona AU - Burns F AD - UCL Institute for Global Health, London, UK. AD - Royal Free London NHS Foundation Trust, London, UK. FAU - Gilson, Richard AU - Gilson R AD - UCL Institute for Global Health, London, UK. AD - Mortimer Market Centre, CNWL NHS Foundation Trust, London, UK. FAU - Fox, Julie AU - Fox J AD - Guys and St Thomas NHS Foundation Trust, London, UK. FAU - Gilleece, Yvonne AU - Gilleece Y AUID- ORCID: 0000-0002-9960-5389 AD - University Hospitals Sussex NHS Trust, Brighton, UK. AD - Brighton & Sussex Medical School, Brighton, UK. FAU - Mackie, Nicola E AU - Mackie NE AD - Imperial College Healthcare NHS Trust, London, UK. FAU - Post, Frank A AU - Post FA AUID- ORCID: 0000-0002-2844-1612 AD - Kings College Hospital NHS Foundation Trust, London, UK. FAU - Reeves, Iain AU - Reeves I AD - Homerton University Hospital NHS Foundation Trust, London, UK. FAU - Rosenvinge, Melanie AU - Rosenvinge M AD - Lewisham and Greenwich NHS Trust, London, UK. FAU - Sullivan, Ann AU - Sullivan A AD - Chelsea and Westminster NHS Foundation Trust, London, UK. FAU - Ustianowski, Andrew AU - Ustianowski A AD - North Manchester General Hospital, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Miller, Robert F AU - Miller RF AD - UCL Institute for Global Health, London, UK. AD - Royal Free London NHS Foundation Trust, London, UK. LA - eng GR - DH_/Department of Health/United Kingdom PT - Journal Article DEP - 20211117 PL - England TA - HIV Med JT - HIV medicine JID - 100897392 RN - 4TI98Z838E (Estradiol) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Child, Preschool MH - Cross-Sectional Studies MH - Estradiol MH - Female MH - *Follicle Stimulating Hormone MH - *HIV Infections/epidemiology MH - Humans MH - Middle Aged MH - Postmenopause PMC - PMC9298721 OTO - NOTNLM OT - HIV OT - ageing OT - follicle-stimulating hormone OT - menopause OT - women COIS- ST has previously received a travel bursary funded by Janssen-Cilag through the British HIV Association, and speaker honoraria and funding for preparation of educational materials from Gilead Sciences. CS has received funding for membership in Data Safety and Monitoring Boards, Advisory Boards, speaker panels and for preparation of educational materials from Gilead Sciences, ViiV Healthcare and Janssen-Cilag. FMB has received consultancy fees and conference support from Gilead Sciences. YG has received funding for Advisory Boards, preparation of educational materials and conference support from ViiV, Janssen-Cilag and Gilead Sciences. NM has received honoraria for participation in advisory boards and educational webinars from ViiV, MSD and Gilead Sciences. IR has had conference support and consultancy fees from ViiV. RM has received speaker honoraria from Gilead. EDAT- 2021/11/19 06:00 MHDA- 2022/03/15 06:00 PMCR- 2022/07/20 CRDT- 2021/11/18 07:56 PHST- 2021/10/21 00:00 [revised] PHST- 2021/06/25 00:00 [received] PHST- 2021/11/02 00:00 [accepted] PHST- 2021/11/19 06:00 [pubmed] PHST- 2022/03/15 06:00 [medline] PHST- 2021/11/18 07:56 [entrez] PHST- 2022/07/20 00:00 [pmc-release] AID - HIV13205 [pii] AID - 10.1111/hiv.13205 [doi] PST - ppublish SO - HIV Med. 2022 Apr;23(4):434-440. doi: 10.1111/hiv.13205. Epub 2021 Nov 17.