PMID- 34792010
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1875-5739 (Electronic)
IS  - 1567-2026 (Linking)
VI  - 18
IP  - 4
DP  - 2021
TI  - The Prognostic Significance of White Blood Cell and Platelet Count for Inhospital 
      Mortality and Pneumonia in Acute Ischemic Stroke.
PG  - 427-434
LID - 10.2174/1567202618666211118141803 [doi]
AB  - BACKGROUND: We investigated the combined effect of white blood cell (WBC) and 
      platelet count on in-hospital mortality and pneumonia in acute ischemic stroke 
      (AIS) patients. METHODS: A total of 3,265 AIS patients enrolled from December 
      2013 to May 2014 across 22 hospitals in Suzhou city were included in the present 
      study. We divided patients into four groups according to their level of WBC and 
      platelet count: LWHP (low WBC and high platelet), LWLP (low WBC and low 
      platelet), HWHP (high WBC and high platelet), and HWLP (high WBC and low 
      platelet). A logistic regression model was used to estimate the combined effect 
      of WBC and platelet counts on all-cause in-hospital mortality and pneumonia in 
      AIS patients. RESULTS: HWLP was associated with a 2.07-fold increase in the risk 
      of in-hospital mortality in comparison to LWHP (adjusted odds ratio (OR) 2.07; 
      95% confidence interval (CI), 1.02-4.18; P-trend =0.020). The risk of pneumonia 
      was significantly higher in patients with HWLP than those with LWHP (adjusted OR 
      2.29; 95% CI, 1.57-3.35; P-trend <0.001). The C-statistic for the combined WBC 
      and platelet count was higher than WBC count or platelet count alone for the 
      prediction of in- -hospital mortality and pneumonia (all P < 0.01). CONCLUSION: 
      High WBC count combined with a low platelet count level at admission was 
      independently associated with in-hospital mortality and pneumonia in AIS 
      patients. Moreover, the combination of WBC count and platelet count level 
      appeared to be a better predictor than WBC count or platelet count alone.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - You, Shoujiang
AU  - You S
AD  - Department of Neurology and Suzhou Clinical Research Center of Neurological 
      Disease, The Second Affiliated Hospital of Soochow University, Suzhou 
      215004,China.
FAU - Sun, Xin
AU  - Sun X
AD  - Department of Neurology and Suzhou Clinical Research Center of Neurological 
      Disease, The Second Affiliated Hospital of Soochow University, Suzhou 
      215004,China.
FAU - Zhou, Yi
AU  - Zhou Y
AD  - Department of Neurology, The First People's Hospital of Taicang, Suzhou 
      215400,China.
FAU - Zhong, Chongke
AU  - Zhong C
AD  - Department of Epidemiology, School of Public Health, Medical College of Soochow 
      University, Suzhou 215123,China.
FAU - Chen, Juping
AU  - Chen J
AD  - Department of Neurology, Hospital of Changshu Traditional Chinese Medicine, 
      Suzhou 215000,China.
FAU - Zhai, Wanqing
AU  - Zhai W
AD  - Department of Neurology, The First People's Hospital of Taicang, Suzhou 
      215400,China.
FAU - Cao, Yongjun
AU  - Cao Y
AD  - Department of Neurology and Suzhou Clinical Research Center of Neurological 
      Disease, The Second Affiliated Hospital of Soochow University, Suzhou 
      215004,China.
LA  - eng
GR  - 81901198/National Natural Science Foundation of China/
GR  - LCZX201806/diagnosis and treatment technology for key clinical diseases in 
      Suzhou/
GR  - 19KJB320004/Natural Science Foundation for Higher Education of Jiangsu Province 
      of China/
GR  - XKTJ-XK202001, XKTJ-TD202004/Discipline Construction Program of the Second 
      Affiliated Hospital of Soochow University/
GR  - 2018QNRC001/Young Elite Scientists Sponsorship Program by China Association for 
      Science and Technology/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United Arab Emirates
TA  - Curr Neurovasc Res
JT  - Current neurovascular research
JID - 101208439
SB  - IM
MH  - *Brain Ischemia/complications/diagnosis
MH  - Hospital Mortality
MH  - Humans
MH  - *Ischemic Stroke
MH  - Leukocytes
MH  - Platelet Count
MH  - *Pneumonia/diagnosis
MH  - Prognosis
MH  - *Stroke
OTO - NOTNLM
OT  - Acute ischemic stroke
OT  - in-hospital outcomes
OT  - platelet count
OT  - pneumonia.
OT  - risk prediction
OT  - white blood cell
EDAT- 2021/11/19 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/11/18 08:45
PHST- 2021/08/22 00:00 [received]
PHST- 2021/09/02 00:00 [revised]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/11/19 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/11/18 08:45 [entrez]
AID - CNR-EPUB-118934 [pii]
AID - 10.2174/1567202618666211118141803 [doi]
PST - ppublish
SO  - Curr Neurovasc Res. 2021;18(4):427-434. doi: 10.2174/1567202618666211118141803.