PMID- 34792425
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20231002
IS  - 2385-2011 (Electronic)
IS  - 1591-0199 (Print)
IS  - 1591-0199 (Linking)
VI  - 28
IP  - 5
DP  - 2022 Oct
TI  - Ticagrelor versus clopidogrel in stent-assisted coil embolization of unruptured 
      intracranial aneurysms.
PG  - 568-574
LID - 10.1177/15910199211054959 [doi]
AB  - BACKGROUND: Dual antiplatelet therapy is widely used for stent-assisted coil 
      embolization (SACE) for unruptured intracranial aneurysms (UIAs) to prevent 
      thromboembolic events (TEs). Compared to clopidogrel associated with aspirin, 
      knowledge of the safety and efficacy of ticagrelor is lacking in large studies to 
      date. METHODS: A retrospective cohort study was conducted from January 2016 to 
      December 2018 with at least one year of follow-up in a single institution and 
      systemic review. RESULTS: Altogether, 153 patients with UIA receiving SACE were 
      separated into two groups: 113 patients receiving clopidogrel plus aspirin and 40 
      patients receiving ticagrelor plus aspirin. Acute in-stent thrombotic events were 
      noted in two patients in the clopidogrel group (1.77%) and none in the ticagrelor 
      group (0%). Additionally, one patient (0.88%) in the clopidogrel group had an 
      early ischemic stroke (<3 months). Delayed ischemic stroke was noted in 6 
      patients (5.31%) in the clopidogrel group and 3 patients (7.50%) in the 
      ticagrelor group. There were no major hemorrhagic events in either group. The two 
      groups showed no significant differences with regard to ischemic stroke or 
      hemorrhagic stroke. CONCLUSION: Compared to the clopidogrel based regimen, 
      ticagrelor can also reduce TEs without increasing bleeding tendency for SACE of 
      UIAs. Ticagrelor combined with low-dose aspirin is a safe and effective 
      alternative option for SACE.
FAU - Chien, Shuo-Chi
AU  - Chien SC
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
FAU - Chen, Ching-Chang
AU  - Chen CC
AUID- ORCID: 0000-0001-6816-3963
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
AD  - New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical 
      Foundation), New Taipei City, Taiwan.
FAU - Chen, Chun-Ting
AU  - Chen CT
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
AD  - New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical 
      Foundation), New Taipei City, Taiwan.
FAU - Wang, Alvin Yi-Chou
AU  - Wang AY
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
FAU - Hsieh, Po-Chuan
AU  - Hsieh PC
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
AD  - New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical 
      Foundation), New Taipei City, Taiwan.
FAU - Yeap, Mun-Chun
AU  - Yeap MC
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
FAU - Liu, Zhuo-Hao
AU  - Liu ZH
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
FAU - Wang, Yu-Chi
AU  - Wang YC
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
FAU - Liu, Yu-Tse
AU  - Liu YT
AD  - Department of Neurosurgery, 38014Chang Gung Memorial Hospital, Linkou Medical 
      Center, Chang Gung University, Taoyuan City, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20211118
PL  - United States
TA  - Interv Neuroradiol
JT  - Interventional neuroradiology : journal of peritherapeutic neuroradiology, 
      surgical procedures and related neurosciences
JID - 9602695
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - GLH0314RVC (Ticagrelor)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Aspirin/therapeutic use
MH  - Clopidogrel/therapeutic use
MH  - *Embolization, Therapeutic/methods
MH  - Humans
MH  - *Intracranial Aneurysm/surgery
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - Retrospective Studies
MH  - Stents
MH  - *Thromboembolism/drug therapy
MH  - Ticagrelor/therapeutic use
MH  - Treatment Outcome
PMC - PMC9511617
OTO - NOTNLM
OT  - Ticagrelor
OT  - dual antiplatelets
OT  - endovascular embolization
OT  - intracranial aneurysm
OT  - stent-assisted coiling
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/11/19 06:00
MHDA- 2022/09/28 06:00
PMCR- 2023/10/01
CRDT- 2021/11/18 12:16
PHST- 2021/11/19 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2021/11/18 12:16 [entrez]
PHST- 2023/10/01 00:00 [pmc-release]
AID - 10.1177_15910199211054959 [pii]
AID - 10.1177/15910199211054959 [doi]
PST - ppublish
SO  - Interv Neuroradiol. 2022 Oct;28(5):568-574. doi: 10.1177/15910199211054959. Epub 
      2021 Nov 18.