PMID- 34792562
OWN - NLM
STAT- MEDLINE
DCOM- 20220708
LR  - 20220711
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
VI  - 61
IP  - 7
DP  - 2022 Jul 6
TI  - Torque Teno Virus quantification for monitoring of immunomodulation with biologic 
      compounds in the treatment of rheumatoid arthritis.
PG  - 2815-2825
LID - 10.1093/rheumatology/keab839 [doi]
AB  - OBJECTIVES: RA patients who fail to respond to MTX can receive biologic dMARDs 
      (bDMARDs). The Torque Teno Virus (TTV) is a potential novel candidate for 
      monitoring of immunosuppression. We explore TTV in these patients and its 
      association with clinical response to bDMARDs. METHODS: The BioBio Study is a 
      multicentre randomized open-label trial, including RA patients with insufficient 
      response to MTX. Patients were randomized to either TNFi (infliximab, INF), 
      anti-IL-6 (tocilizumab, TCZ), CTLA4-Ig (abatacept, ABA) or anti-CD20 (rituximab, 
      RTX) in addition to MTX. PCR was used to quantify TTV in the peripheral blood. 
      RESULTS: TTV was measured in 95 patients (INF, n = 23; TCZ, n = 22; ABA, n = 27; 
      RTX; n = 23). TTV increased by a median of 4.5 x 104 copies/ml [c/ml; 
      interquartile range (IQR) 0-7.5 x 105] after 3 months. TTV levels at month 3 were 
      associated with the Simplified Disease Activity Index (SDAI) (P = 0.03) and the 
      Clinical Disease Activity Index (CDAI) response (P = 0.026) at month 6. A TTV 
      cut-off level of 1.2 x 106 c/ml at month 3 had a positive likelihood ratio of 2.7 
      for prediction of an 85% reduction in SDAI at month 6. CONCLUSION: Our data 
      suggest that TTV levels increase upon TNF, CD20 and costimulation blockade and 
      are associated with the clinical response to bDMARDs in RA patients. TRIAL 
      REGISTRATION: ClinicalTrials.gov; https://clinicaltrials.gov; NCT01638715.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Studenic, Paul
AU  - Studenic P
AUID- ORCID: 0000-0002-8895-6941
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
AD  - Division of Rheumatology, Department of Medicine (Solna), Karolinska Institutet, 
      Solna, Sweden.
FAU - Bond, Gregor
AU  - Bond G
AUID- ORCID: 0000-0003-0440-3053
AD  - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, 
      Austria.
FAU - Kerschbaumer, Andreas
AU  - Kerschbaumer A
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Becede, Manuel
AU  - Becede M
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Pavelka, Karel
AU  - Pavelka K
AD  - Institute of Rheumatology.
AD  - Department of Rheumatology, First Faculty of Medicine, Charles University, 
      Prague, Czech Republic.
FAU - Karateev, Dmitry
AU  - Karateev D
AD  - Department of Rheumatology, Moscow Regional Research and Clinical Institute 
      (MONIKI), Moscow, Russia.
FAU - Stieger, Jutta
AU  - Stieger J
AD  - 2nd Department of Medicine, Hietzing Hospital, Vienna.
FAU - Puchner, Rudolf
AU  - Puchner R
AD  - Rheumatologist in Private Practice, Wels, Austria.
FAU - Mueller, Ruediger B
AU  - Mueller RB
AD  - Cantonal Hospital Lucerne, Division of Rheumatology, Medical University 
      Department, Rheumazentrum Ostschweiz, St. Gallen, Switzerland.
FAU - Puchhammer-Stockl, Elisabeth
AU  - Puchhammer-Stockl E
AD  - Center of Virology.
FAU - Durechova, Martina
AU  - Durechova M
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Loiskandl, Michaela
AU  - Loiskandl M
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Perkmann, Thomas
AU  - Perkmann T
AD  - Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
FAU - Olejarova, Martina
AU  - Olejarova M
AD  - Institute of Rheumatology.
AD  - Department of Rheumatology, First Faculty of Medicine, Charles University, 
      Prague, Czech Republic.
FAU - Luchikhina, Elena
AU  - Luchikhina E
AD  - Department of Rheumatology, Moscow Regional Research and Clinical Institute 
      (MONIKI), Moscow, Russia.
FAU - Steiner, Carl-Walter
AU  - Steiner CW
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Bonelli, Michael
AU  - Bonelli M
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Smolen, Josef S
AU  - Smolen JS
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
FAU - Aletaha, Daniel
AU  - Aletaha D
AUID- ORCID: 0000-0003-2108-0030
AD  - Department of Internal Medicine 3, Division of Rheumatology, Medical University 
      of Vienna, Vienna, Austria.
LA  - eng
SI  - ClinicalTrials.gov/NCT01638715
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
RN  - 7D0YB67S97 (Abatacept)
SB  - IM
MH  - Abatacept/therapeutic use
MH  - *Antirheumatic Agents/therapeutic use
MH  - *Arthritis, Rheumatoid/drug therapy
MH  - *Biological Products/therapeutic use
MH  - Humans
MH  - Immunomodulation
MH  - *Torque teno virus
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Torque Teno Virus
OT  - bDMARDs
OT  - methotrexate
OT  - outcomes
OT  - rheumatoid arthritis
OT  - treatment response
EDAT- 2021/11/19 06:00
MHDA- 2022/07/09 06:00
CRDT- 2021/11/18 12:22
PHST- 2021/05/02 00:00 [received]
PHST- 2021/11/02 00:00 [revised]
PHST- 2021/11/19 06:00 [pubmed]
PHST- 2022/07/09 06:00 [medline]
PHST- 2021/11/18 12:22 [entrez]
AID - 6430998 [pii]
AID - 10.1093/rheumatology/keab839 [doi]
PST - ppublish
SO  - Rheumatology (Oxford). 2022 Jul 6;61(7):2815-2825. doi: 
      10.1093/rheumatology/keab839.