PMID- 34792726 OWN - NLM STAT- MEDLINE DCOM- 20220419 LR - 20220716 IS - 1699-3055 (Electronic) IS - 1699-048X (Print) IS - 1699-048X (Linking) VI - 24 IP - 5 DP - 2022 May TI - Quantitative assessments of late radiation-induced skin and soft tissue toxicity and correlation with RTOG scales and biological equivalent dose in breast cancer. PG - 836-845 LID - 10.1007/s12094-021-02729-z [doi] AB - PURPOSE: Radiation-induced toxicity (RIT) is usually assessed by inspection and palpation. Due to their subjective and unquantitative nature, objective methods are required. This study aimed to determine whether a quantitative tool is able to assess RIT and establish an underlying BED-response relationship in breast cancer. METHODS: Patients following seven different breast radiation protocols were recruited to this study for RIT assessment with qualitative and quantitative examination. The biologically equivalent dose (BED) was used to directly compare different radiation regimens. RIT was subjectively evaluated by physicians using the Radiation Therapy Oncology Group (RTOG) late toxicity scores. Simultaneously an objective multiprobe device was also used to quantitatively assess late RIT in terms of erythema, hyperpigmentation, elasticity and skin hydration. RESULTS: In 194 patients, in terms of the objective measurements, treated breasts showed higher erythema and hyperpigmentation and lower elasticity and hydration than untreated breasts (p < 0.001, p < 0.001, p < 0.001, p = 0.019, respectively). As the BED increased, Deltaerythema and Deltapigmentation gradually increased as well (p = 0.006 and p = 0.002, respectively). Regarding the clinical assessment, the increase in BED resulted in a higher RTOG toxicity grade (p < 0.001). Quantitative assessments were consistent with RTOG scores. As the RTOG toxicity grade increased, the erythema and pigmentation values increased, and the elasticity index decreased (p < 0.001, p = 0.016, p = 0.005, respectively). CONCLUSIONS: The multiprobe device can be a sensitive and simple tool for research purpose and quantitatively assessing RIT in patients undergoing radiotherapy for breast cancer. Physician-assessed toxicity scores and objective measurements revealed that the BED was positively associated with the severity of RIT. CI - (c) 2021. The Author(s). FAU - Huang, Y AU - Huang Y AD - Autonomous University of Barcelona, Barcelona, Spain. FAU - Sanz, J AU - Sanz J AUID- ORCID: 0000-0003-2296-9659 AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. jsanz@psmar.cat. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. jsanz@psmar.cat. AD - Radiation Oncology Department, Hospital del Mar, Edifici B, c/Gas s/n Planta-2, 08003, Barcelona, Spain. jsanz@psmar.cat. FAU - Rodriguez, N AU - Rodriguez N AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. FAU - Duran, X AU - Duran X AD - Statistics Department, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. FAU - Martinez, A AU - Martinez A AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Li, X AU - Li X AD - Autonomous University of Barcelona, Barcelona, Spain. FAU - Foro, P AU - Foro P AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. FAU - Conde, M AU - Conde M AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Zhao, M AU - Zhao M AD - Autonomous University of Barcelona, Barcelona, Spain. FAU - Liu, F AU - Liu F AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Reig, A AU - Reig A AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. FAU - Dengra, J AU - Dengra J AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Membrive, I AU - Membrive I AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. FAU - Perez, P AU - Perez P AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. FAU - Algara, M AU - Algara M AD - Autonomous University of Barcelona, Barcelona, Spain. AD - Radiation Oncology Department, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. AD - Radiation Oncology Research Group, Institut Hospital del Mar d'Investigacions Mediques, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20211118 PL - Italy TA - Clin Transl Oncol JT - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico JID - 101247119 SB - IM MH - Breast MH - *Breast Neoplasms/radiotherapy MH - Erythema/etiology MH - Female MH - Humans MH - *Hyperpigmentation/etiology MH - *Radiation Injuries MH - Skin PMC - PMC8600910 OTO - NOTNLM OT - Biological equivalent dose OT - Breast cancer OT - Objective evaluation OT - Quantitative assessment OT - Radiation-induced toxicity OT - Radiotherapy COIS- The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2021/11/19 06:00 MHDA- 2022/04/20 06:00 PMCR- 2021/11/18 CRDT- 2021/11/18 12:29 PHST- 2021/08/12 00:00 [received] PHST- 2021/10/31 00:00 [accepted] PHST- 2021/11/19 06:00 [pubmed] PHST- 2022/04/20 06:00 [medline] PHST- 2021/11/18 12:29 [entrez] PHST- 2021/11/18 00:00 [pmc-release] AID - 10.1007/s12094-021-02729-z [pii] AID - 2729 [pii] AID - 10.1007/s12094-021-02729-z [doi] PST - ppublish SO - Clin Transl Oncol. 2022 May;24(5):836-845. doi: 10.1007/s12094-021-02729-z. Epub 2021 Nov 18.