PMID- 34794472
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211122
IS  - 1742-4933 (Print)
IS  - 1742-4933 (Electronic)
IS  - 1742-4933 (Linking)
VI  - 18
IP  - 1
DP  - 2021 Nov 18
TI  - Quantification of dendritic cell subsets in human thymus tissues of various ages.
PG  - 44
LID - 10.1186/s12979-021-00255-8 [doi]
LID - 44
AB  - BACKGROUND: Dendritic cells (DCs) in the thymus are involved in central tolerance 
      formation, but they also have other functions in the thymus, such as pathogen 
      recognition. The density changes of human thymic DCs have been hardly 
      investigated. In this study, human thymus samples of various ages were collected 
      for tissue sectioning and staining. The thymic cortex and medulla area as well as 
      the densities of various subsets of thymic DCs were calculated. RESULTS: All 
      common DC subsets were found in the human thymus of various ages. Most DCs had 
      accumulated in the human thymic epithelial space, especially the medulla. We also 
      found that the human thymic cortex had atrophied relatively faster than the 
      medulla, which led to a gradual increase of the area ratio of the medulla to 
      cortex with the increase of age. The densities of DC subsets in the human thymus 
      showed various changes with increasing age, which contributed to the composition 
      changes of DC subsets. The density of plasmacytoid DCs (pDCs) in the human thymus 
      had increased gradually with aging, which suggested that pDCs plays another 
      essential role in the thymus in addition to central tolerance. CONCLUSIONS: 
      Inconsistent with the shrinking of the epithelial space in the thymus, the 
      densities of DC subsets in the epithelial space of the thymus are maintained at a 
      constant level with aging to preserve highly efficient autoreactive thymocyte 
      screening. An increasing density of the thymic pDCs with aging implies an extra 
      function of DCs in the thymus beyond central tolerance.
CI  - (c) 2021. The Author(s).
FAU - Li, Yan
AU  - Li Y
AD  - Department of Neurosurgical Intensive Care Unit, The First Affiliated Hospital of 
      Sun Yat-sen University, Guangzhou, 510080, China.
FAU - Chen, Pei
AU  - Chen P
AD  - Department of Neurology, National Key Clinical Department and Key Discipline of 
      Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 
      510080, China.
FAU - Huang, Hao
AU  - Huang H
AD  - Department of Neurology, The First People's Hospital of Nanning, Nanning, 530022, 
      China.
FAU - Feng, Huiyu
AU  - Feng H
AD  - Department of Neurology, National Key Clinical Department and Key Discipline of 
      Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 
      510080, China.
FAU - Ran, Hao
AU  - Ran H
AD  - School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, 
      China. baseballman_81@msn.com.
FAU - Liu, Weibin
AU  - Liu W
AD  - Department of Neurology, National Key Clinical Department and Key Discipline of 
      Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 
      510080, China. liuwb@mail.sysu.edu.cn.
LA  - eng
GR  - 81801249/National Natural Science Foundation of China/
GR  - 81873772/National Natural Science Foundation of China/
GR  - 81620108010/National Natural Science Foundation of China/
GR  - 2010003/Sun Yat-sen University/
GR  - 2007B16002039/Science and Technology Planned Project of Guangdong in China/
GR  - 2014B030301035/National Key Clinical Department and Key Discipline of Neurology, 
      Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major 
      Neurological Diseases/
GR  - 2015B050501003/Southern China International Cooperation Base for Early 
      Intervention and Functional Rehabilitation of Neurological Diseases/
GR  - 201604020010/Guangdong Provincial Engineering Center for Major Neurological 
      Disease Treatment, Science and Technology Planning Project of Guangzhou/
PT  - Journal Article
DEP - 20211118
PL  - England
TA  - Immun Ageing
JT  - Immunity & ageing : I & A
JID - 101235427
PMC - PMC8600781
OTO - NOTNLM
OT  - Aging
OT  - Dendritic cell
OT  - Myeloid dendritic cell
OT  - Plasmacytoid dendritic cell
OT  - Thymus
COIS- The authors declare that they have no competing interests.
EDAT- 2021/11/20 06:00
MHDA- 2021/11/20 06:01
PMCR- 2021/11/18
CRDT- 2021/11/19 05:37
PHST- 2021/06/07 00:00 [received]
PHST- 2021/10/28 00:00 [accepted]
PHST- 2021/11/19 05:37 [entrez]
PHST- 2021/11/20 06:00 [pubmed]
PHST- 2021/11/20 06:01 [medline]
PHST- 2021/11/18 00:00 [pmc-release]
AID - 10.1186/s12979-021-00255-8 [pii]
AID - 255 [pii]
AID - 10.1186/s12979-021-00255-8 [doi]
PST - epublish
SO  - Immun Ageing. 2021 Nov 18;18(1):44. doi: 10.1186/s12979-021-00255-8.