PMID- 34798597
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240517
IS  - 1547-5646 (Electronic)
IS  - 1547-5646 (Linking)
VI  - 36
IP  - 5
DP  - 2022 May 1
TI  - Two-year validation and minimal clinically important difference of the Veterans 
      RAND 12 Item Health Survey Physical Component Score in patients undergoing 
      minimally invasive transforaminal lumbar interbody fusion.
PG  - 731-740
LID - 10.3171/2021.6.SPINE21231 [doi]
AB  - OBJECTIVE: The Physical Component Score of the Veterans RAND 12 Item Health 
      Survey (VR-12 PCS) has been assessed for use at short-term and intermediate-term 
      time points for lumbar fusion populations. This study assesses the long-term 
      validity and establishes minimal clinically important difference (MCID) values of 
      VR-12 PCS in patients undergoing minimally invasive transforaminal lumbar 
      interbody fusion (MIS TLIF). METHODS: A surgical registry was retrospectively 
      reviewed for primary, elective, single-level MIS TLIF procedures with posterior 
      instrumentation. Patients missing preoperative and 2-year postoperative VR-12 PCS 
      survey data were excluded. VR-12 PCS, SF-12 Health Survey Physical Component 
      Summary (SF-12 PCS), Patient-Reported Outcomes Measurement Information System 
      Physical Function (PROMIS PF), and Oswestry Disability Index (ODI) 
      patient-reported outcome measures (PROMs) were recorded preoperatively and 
      postoperatively. Responsiveness of the VR-12 measure was assessed in two ways. 
      First, the mean postoperative PROM scores were compared with preoperative 
      baseline values using a paired Student t-test. Second, MCID values were 
      calculated using both distribution-based and anchor-based methods and used to 
      assess improvement in VR-12 score at the 2-year time point. Discriminant validity 
      of the VR-12 was assessed using cross-sectional and longitudinal anchors. 
      Convergent validity of the VR-12 measure was assessed using Pearson's correlation 
      coefficient and partial time-independent correlation. Floor and ceiling effects 
      were assessed. RESULTS: A total of 74 patients who underwent MIS TLIF were 
      included. The VR-12 PCS demonstrated significant improvements at all time points 
      from 12 weeks to 2 years (p < 0.001 for all). VR-12 PCSs were significantly 
      different for patients classified using cross-sectional anchors (p < 0.001) and 
      longitudinal anchors (p </= 0.005). Calculated MCID values ranged from 4.1 to 8.5, 
      and 4.1 was selected as the optimal MCID, which 87.8% of patients achieved. 
      Strong, significant correlations of the VR-12 PCS with SF-12 PCS and PROMIS PF 
      were demonstrated at all time points (p < 0.001 for all). No significant floor or 
      ceiling effects were detected. CONCLUSIONS: The VR-12 PCS demonstrated excellent 
      responsiveness, discriminant and convergent validity, and no significant floor or 
      ceiling effects up to 2 years after MIS TLIF. Therefore, VR-12 PCS may serve as a 
      valid measure of long-term physical function.
FAU - Lynch, Conor P
AU  - Lynch CP
FAU - Cha, Elliot D K
AU  - Cha EDK
FAU - Mohan, Shruthi
AU  - Mohan S
FAU - Geoghegan, Cara E
AU  - Geoghegan CE
FAU - Jadczak, Caroline N
AU  - Jadczak CN
FAU - Singh, Kern
AU  - Singh K
LA  - eng
PT  - Journal Article
DEP - 20211119
PL  - United States
TA  - J Neurosurg Spine
JT  - Journal of neurosurgery. Spine
JID - 101223545
SB  - IM
OTO - NOTNLM
OT  - MCID
OT  - PRO
OT  - TLIF
OT  - VR-12
OT  - minimal clinically important difference
OT  - patient-reported outcomes
OT  - transforaminal lumbar interbody fusion
EDAT- 2021/11/20 06:00
MHDA- 2021/11/20 06:01
CRDT- 2021/11/19 20:37
PHST- 2021/02/09 00:00 [received]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/11/20 06:01 [medline]
PHST- 2021/11/20 06:00 [pubmed]
PHST- 2021/11/19 20:37 [entrez]
AID - 10.3171/2021.6.SPINE21231 [doi]
PST - epublish
SO  - J Neurosurg Spine. 2021 Nov 19;36(5):731-740. doi: 10.3171/2021.6.SPINE21231. 
      Print 2022 May 1.