PMID- 34798819 OWN - NLM STAT- MEDLINE DCOM- 20220110 LR - 20220110 IS - 1471-2318 (Electronic) IS - 1471-2318 (Linking) VI - 21 IP - 1 DP - 2021 Nov 19 TI - Outcomes between prediabetes and type 2 diabetes mellitus in older adults with acute myocardial infarction in the era of newer-generation drug-eluting stents: a retrospective observational study. PG - 653 LID - 10.1186/s12877-021-02601-3 [doi] LID - 653 AB - BACKGROUND: The comparative clinical outcomes between prediabetes and type 2 diabetes mellitus (T2DM) in older adults with AMI in the era of newer-generation drug-eluting stents (DES) are limited. We investigated the 2-year clinical outcomes of these patients. METHODS: A total of 5492 AMI patients aged >/=65 years were classified into three groups according to their glycemic status: normoglycemia (group A: 1193), prediabetes (group B: 1696), and T2DM (group C: 2603). The primary outcome was the occurrence of major adverse cardiac events (MACE), defined as all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization. The secondary outcome was stent thrombosis (ST). RESULTS: The primary and secondary outcomes cumulative incidences were similar between the prediabetes and T2DM groups. In both the prediabetes and T2DM groups, the cumulative incidences of MACE (adjusted hazard ratio [aHR]: 1.373; p = 0.020 and aHR: 1.479; p = 0.002, respectively) and all-cause death or MI (aHR: 1.436; p = 0.022 and aHR: 1.647; p = 0.001, respectively) were significantly higher than those in the normoglycemia group. Additionally, the cumulative incidence of all-cause death in the T2DM group was significantly higher than that in the normoglycemia group (aHR, 1.666; p = 0.003). CONCLUSIONS: In this retrospective study, despite the 2-year clinical outcomes of the patients with prediabetes and T2DM in the older adults were worse than those in the normoglycemia group; they were similar between the prediabetes and T2DM groups. Hence, comparable treatment strategies should be strengthened between prediabetes and T2DM in older adults with AMI. TRIAL REGISTRATION: Retrospectively registered. CI - (c) 2021. The Author(s). FAU - Kim, Yong Hoon AU - Kim YH AUID- ORCID: 0000-0002-9669-3598 AD - Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, 24289, 156 Baengnyeong Road, Chuncheon City, Gangwon Province, South Korea. yhkim02@kangwon.ac.kr. FAU - Her, Ae-Young AU - Her AY AUID- ORCID: 0000-0002-9990-6843 AD - Division of Cardiology, Department of Internal Medicine, Kangwon National University School of Medicine, 24289, 156 Baengnyeong Road, Chuncheon City, Gangwon Province, South Korea. FAU - Jeong, Myung Ho AU - Jeong MH AUID- ORCID: 0000-0003-2424-810X AD - Department of Cardiology, Chonnam National University Hospital, Gwangju, Republic of Korea. FAU - Kim, Byeong-Keuk AU - Kim BK AUID- ORCID: 0000-0003-2493-066X AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Hong, Sung-Jin AU - Hong SJ AUID- ORCID: 0000-0003-4893-039X AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Park, Sang-Ho AU - Park SH AUID- ORCID: 0000-0001-7912-0336 AD - Cardiology Department, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea. FAU - Kim, Byung Gyu AU - Kim BG AD - Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea. FAU - Kim, Seunghwan AU - Kim S AUID- ORCID: 0000-0001-6783-3849 AD - Division of Cardiology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, Republic of Korea. FAU - Ahn, Chul-Min AU - Ahn CM AUID- ORCID: 0000-0002-7071-4370 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Kim, Jung-Sun AU - Kim JS AUID- ORCID: 0000-0003-2263-3274 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Ko, Young-Guk AU - Ko YG AUID- ORCID: 0000-0001-7748-5788 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Choi, Donghoon AU - Choi D AUID- ORCID: 0000-0002-2009-9760 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Hong, Myeong-Ki AU - Hong MK AUID- ORCID: 0000-0002-2090-2031 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Jang, Yangsoo AU - Jang Y AUID- ORCID: 0000-0002-2169-3112 AD - Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20211119 PL - England TA - BMC Geriatr JT - BMC geriatrics JID - 100968548 SB - IM MH - Aged MH - *Diabetes Mellitus, Type 2/diagnosis/epidemiology MH - *Drug-Eluting Stents MH - Humans MH - *Myocardial Infarction/diagnosis/epidemiology MH - *Percutaneous Coronary Intervention/adverse effects MH - *Prediabetic State/diagnosis/epidemiology MH - Retrospective Studies MH - Treatment Outcome PMC - PMC8603514 OTO - NOTNLM OT - Diabetes OT - Elderly OT - Myocardial infarction OT - Prediabetes COIS- The authors declare that they have no competing interests. EDAT- 2021/11/21 06:00 MHDA- 2022/01/11 06:00 PMCR- 2021/11/19 CRDT- 2021/11/20 05:20 PHST- 2021/05/15 00:00 [received] PHST- 2021/11/02 00:00 [accepted] PHST- 2021/11/20 05:20 [entrez] PHST- 2021/11/21 06:00 [pubmed] PHST- 2022/01/11 06:00 [medline] PHST- 2021/11/19 00:00 [pmc-release] AID - 10.1186/s12877-021-02601-3 [pii] AID - 2601 [pii] AID - 10.1186/s12877-021-02601-3 [doi] PST - epublish SO - BMC Geriatr. 2021 Nov 19;21(1):653. doi: 10.1186/s12877-021-02601-3.