PMID- 34799151
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 83
IP  - 2
DP  - 2022 Feb
TI  - Graphical user interface for the haplotype frequency estimation software 
      Hapl-o-Mat.
PG  - 107-112
LID - S0198-8859(21)00255-X [pii]
LID - 10.1016/j.humimm.2021.11.002 [doi]
AB  - Population-specific human leukocyte antigen (HLA) haplotype frequencies are an 
      essential basis of advanced algorithms for donor selection in unrelated 
      hematopoietic stem cell transplantation. In 2016, we introduced Hapl-o-Mat, a 
      versatile tool for haplotype frequency estimation based on an 
      expectation-maximization algorithm (https://github.com/DKMS/hapl-o-Mat). 
      Hapl-o-Mat is specifically tailored to the analysis of HLA genes and able to cope 
      with the heterogeneous genotyping data usually found in donor registries. To make 
      Hapl-o-Mat accessible to a wider range of users, we designed a graphical user 
      interface module that considerably facilitates the interaction with the 
      application (https://github.com/DKMS/hapl-o-Mat_GUI). We further provide a 
      precompiled version of Hapl-o-Mat that can be used on Windows personal computers 
      without dependency on additional software libraries 
      (https://github.com/DKMS/hapl-o-Mat_WinBin). We are confident that these new, 
      user-oriented features will encourage more researchers to apply Hapl-o-Mat to 
      their data, thereby increasing knowledge and public availability of 
      population-specific HLA haplotype frequencies.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Solloch, Ute V
AU  - Solloch UV
AD  - DKMS, Tubingen, Germany. Electronic address: solloch@dkms.de.
FAU - Schmidt, Alexander H
AU  - Schmidt AH
AD  - DKMS, Tubingen, Germany.
FAU - Sauter, Jurgen
AU  - Sauter J
AD  - DKMS, Tubingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20211116
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Gene Frequency
MH  - *HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - *Software
MH  - Tissue Donors
OTO - NOTNLM
OT  - HLA
OT  - HSCT
OT  - Haplotype frequencies
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/11/21 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/11/20 05:30
PHST- 2021/06/14 00:00 [received]
PHST- 2021/10/07 00:00 [revised]
PHST- 2021/11/04 00:00 [accepted]
PHST- 2021/11/21 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/11/20 05:30 [entrez]
AID - S0198-8859(21)00255-X [pii]
AID - 10.1016/j.humimm.2021.11.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2022 Feb;83(2):107-112. doi: 10.1016/j.humimm.2021.11.002. Epub 2021 
      Nov 16.