PMID- 34800316
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20220731
IS  - 1467-7687 (Electronic)
IS  - 1363-755X (Print)
IS  - 1363-755X (Linking)
VI  - 25
IP  - 3
DP  - 2022 May
TI  - Developmental differences in the prospective organisation of goal-directed 
      movement between children with autism and typically developing children: A smart 
      tablet serious game study.
PG  - e13195
LID - 10.1111/desc.13195 [doi]
LID - e13195
AB  - Movement is prospective. It structures self-generated engagement with objects and 
      social partners and is fundamental to children's learning and development. In 
      autistic children, previous reports of differences in movement kinematics 
      compared to neurotypical peers suggest that its prospective organisation might be 
      disrupted. Here, we employed a smart tablet serious game paradigm to assess 
      differences in the feedforward and feedback mechanisms of prospective action 
      organisation, between autistic and neurotypical preschool children. We analysed 
      3926 goal-directed finger movements made during smart-tablet ecological gameplay, 
      from 28 children with Childhood Autism (ICD-10; ASD) and 43 neurotypical children 
      (TD), aged 3-6 years old. Using linear and generalised linear mixed-effect 
      models, we found the ASD group executed movements with longer movement time (MT) 
      and time to peak velocity (TTPV), lower peak velocity (PV), with PV less likely 
      to occur in the first movement unit (MU) and with a greater number of movement 
      units after peak velocity (MU-APV). Interestingly, compared to the TD group, the 
      ASD group showed smaller increases in PV, TTPV and MT with an increase in age 
      (ASD x age interaction), together with a smaller reduction in MU-APV and an 
      increase in MU-APV at shorter target distances (ASD x Dist interaction). Our 
      results are the first to highlight different developmental trends in anticipatory 
      feedforward and compensatory feedback mechanisms of control, contributing to 
      differences in movement kinematics observed between autistic and neurotypical 
      children. These findings point to differences in integration of prospective 
      perceptuomotor information, with implications for embodied cognition and learning 
      from self-generated action in autism.
CI  - (c) 2021 The Authors. Developmental Science published by John Wiley & Sons Ltd.
FAU - Chua, Yu Wei
AU  - Chua YW
AUID- ORCID: 0000-0002-2174-6149
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Faculty of Humanities and Social Sciences, University of Strathclyde, Glasgow, 
      Scotland, UK.
FAU - Lu, Szu-Ching
AU  - Lu SC
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Faculty of Humanities and Social Sciences, University of Strathclyde, Glasgow, 
      Scotland, UK.
FAU - Anzulewicz, Anna
AU  - Anzulewicz A
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Sobota, Krzystof
AU  - Sobota K
AD  - Faculty of Psychology, University of Warsaw, Warsaw, Poland.
FAU - Tachtatzis, Christos
AU  - Tachtatzis C
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Department of Electronic and Electrical Engineering, University of Strathclyde, 
      Glasgow, Scotland, UK.
FAU - Andonovic, Ivan
AU  - Andonovic I
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Department of Electronic and Electrical Engineering, University of Strathclyde, 
      Glasgow, Scotland, UK.
FAU - Rowe, Philip
AU  - Rowe P
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Department of Biomedical Engineering, University of Strathclyde, Glasgow, 
      Scotland, UK.
FAU - Delafield-Butt, Jonathan
AU  - Delafield-Butt J
AUID- ORCID: 0000-0002-8881-8821
AD  - Laboratory for Innovation in Autism, University of Strathclyde, Glasgow, 
      Scotland, UK.
AD  - Faculty of Humanities and Social Sciences, University of Strathclyde, Glasgow, 
      Scotland, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211206
PL  - England
TA  - Dev Sci
JT  - Developmental science
JID - 9814574
RN  - 0 (Tablets)
SB  - IM
MH  - *Autism Spectrum Disorder
MH  - *Autistic Disorder
MH  - Child
MH  - Child, Preschool
MH  - Goals
MH  - Humans
MH  - Prospective Studies
MH  - Tablets
PMC - PMC9287065
OTO - NOTNLM
OT  - autism
OT  - embodiment
OT  - feed-forward and feed-back mechanisms
OT  - prospective motor control
OT  - smart tablet serious game paradigms
COIS- The authors declare no conflict of interest in this work.
EDAT- 2021/11/21 06:00
MHDA- 2022/04/16 06:00
PMCR- 2022/07/15
CRDT- 2021/11/20 12:12
PHST- 2021/10/15 00:00 [revised]
PHST- 2021/06/01 00:00 [received]
PHST- 2021/11/15 00:00 [accepted]
PHST- 2021/11/21 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2021/11/20 12:12 [entrez]
PHST- 2022/07/15 00:00 [pmc-release]
AID - DESC13195 [pii]
AID - 10.1111/desc.13195 [doi]
PST - ppublish
SO  - Dev Sci. 2022 May;25(3):e13195. doi: 10.1111/desc.13195. Epub 2021 Dec 6.