PMID- 34800468
OWN - NLM
STAT- MEDLINE
DCOM- 20220307
LR  - 20221216
IS  - 1879-0712 (Electronic)
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 913
DP  - 2021 Dec 15
TI  - Lack of evidence for positive reinforcing and prosocial effects of MDMA in 
      pair-housed male and female rats.
PG  - 174646
LID - S0014-2999(21)00802-5 [pii]
LID - 10.1016/j.ejphar.2021.174646 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is classified as an entactogen, 
      producing feelings of emotional openness and relatedness. One unique feature of 
      MDMA is that people tend to selectively take this drug in social and/or intimate 
      situations. Although MDMA is recognized as having abuse liability, preclinical 
      studies report that it has weak reinforcing effects in animals. The objective of 
      this study was to characterize the positive reinforcing and prosocial effects of 
      MDMA in a translational model of the social environment in which two rats have 
      simultaneous and contingent access to MDMA in close physical proximity. To this 
      end, MDMA self-administration was examined on both fixed and progressive ratio 
      schedules of reinforcement in six groups of rats: (1) isolated males, (2) 
      isolated females, (3) male-male dyads, (4) female-female dyads, (5) male-female 
      dyads, and (6) female-male dyads. For pair-housed rats, data from both rats were 
      analyzed. Next, social preferences were examined in a partner preference test. 
      MDMA failed to produce positive reinforcing effects under all conditions 
      examined. Across a 30-fold dose range (0.01-1.0 mg/kg/infusion), MDMA did not 
      maintain higher responding than saline on both schedules of reinforcement and in 
      all groups tested. In partner preference tests, a history of shared exposure to 
      MDMA did not establish a social preference, and acute administration of MDMA 
      failed to establish a preference for another MDMA-treated rat. These data suggest 
      that social contact does not increase the positive reinforcing effects of MDMA in 
      rats, and that neither contingent nor noncontingent MDMA administration 
      establishes a social preference in rats.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Smith, Mark A
AU  - Smith MA
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA. Electronic address: masmith@davidson.edu.
FAU - Schmidt, Karl T
AU  - Schmidt KT
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
FAU - Sharp, Jessica L
AU  - Sharp JL
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
FAU - Pearson, Tallia
AU  - Pearson T
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
FAU - Davis, Anna L
AU  - Davis AL
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
FAU - Gibson, Abigail N
AU  - Gibson AN
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
FAU - Potter, Kenzie M
AU  - Potter KM
AD  - Department of Psychology and Program in Neuroscience, Davidson College, Davidson, 
      NC, USA.
LA  - eng
GR  - R01 DA031725/DA/NIDA NIH HHS/United States
GR  - R01 DA045364/DA/NIDA NIH HHS/United States
GR  - R03 DA045714/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20211117
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Models, Animal
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - *Reinforcement, Psychology
MH  - Self Administration
MH  - Social Interaction/*drug effects
PMC - PMC8675402
MID - NIHMS1759607
OTO - NOTNLM
OT  - Ecstasy
OT  - Molly
OT  - Partner preference
OT  - Self-administration
OT  - Social behavior
OT  - Social choice
EDAT- 2021/11/21 06:00
MHDA- 2022/03/08 06:00
PMCR- 2022/12/15
CRDT- 2021/11/20 20:10
PHST- 2021/08/18 00:00 [received]
PHST- 2021/11/14 00:00 [revised]
PHST- 2021/11/15 00:00 [accepted]
PHST- 2021/11/21 06:00 [pubmed]
PHST- 2022/03/08 06:00 [medline]
PHST- 2021/11/20 20:10 [entrez]
PHST- 2022/12/15 00:00 [pmc-release]
AID - S0014-2999(21)00802-5 [pii]
AID - 10.1016/j.ejphar.2021.174646 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2021 Dec 15;913:174646. doi: 10.1016/j.ejphar.2021.174646. Epub 
      2021 Nov 17.