PMID- 34801772
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 1527-3288 (Electronic)
IS  - 0147-9563 (Linking)
VI  - 52
DP  - 2022 Mar-Apr
TI  - Increased Pulmonary Arterial Compliance after Balloon Pulmonary Angioplasty 
      Predicts Exercise Tolerance Improvement in Inoperable CTEPH Patients with Lower 
      Pulmonary Arterial Pressure.
PG  - 8-15
LID - S0147-9563(21)00271-5 [pii]
LID - 10.1016/j.hrtlng.2021.11.003 [doi]
AB  - BACKGROUND: Balloon pulmonary angioplasty (BPA) improved pulmonary arterial 
      compliance (C(PA)) and exercise tolerance in patients with inoperable chronic 
      thromboembolic pulmonary hypertension (CTEPH). OBJECTIVES: To investigate whether 
      C(PA) is a useful index to indicate exercise tolerance improvement by BPA in 
      CTEPH patients. METHODS: The correlation between changes in C(PA) and 
      improvements in 6-minute walk distance (6MWD) by BPA was retrospectively analyzed 
      in 70 patients (Analysis 1), and it was sequentially analyzed in 46 symptomatic 
      patients who achieved mean pulmonary arterial pressure (mPAP)<30mmHg (Analysis 
      2). RESULTS: We enrolled 70 patients (female/male:57/13, mean age:59 years) who 
      underwent a total of 352 BPA sessions which significantly increased C(PA) 
      (1.5+/-0.8 vs. 3.0+/-1.0 mL/mmHg) and decreased pulmonary vascular resistance (PVR) 
      (8.0 +/- 3.9 vs. 3.6 +/- 1.7 wood units). The correlation coefficient between 
      improvement in 6MWD and changes in PVR and C(PA) were r=0.21 (p=0.09) and r=0.14 
      (p=0.26) (Analysis 1). In Analysis 2, those were r=0.32 (p=0.06) and r=0.38 
      (p=0.02), respectively. CONCLUSIONS: C(PA) can be a useful index to indicate the 
      improvement in exercise tolerance by BPA in symptomatic patients with lower mPAP.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Umemoto, Shintaro
AU  - Umemoto S
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Department of Cardiovascular Medicine, Research 
      Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Abe, Kohtaro
AU  - Abe K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Department of Cardiovascular Medicine, Research 
      Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, 
      Fukuoka, Japan. Electronic address: koabe@cardiol.med.kyushu-u.ac.jp.
FAU - Hosokawa, Kazuya
AU  - Hosokawa K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Horimoto, Koshin
AU  - Horimoto K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Department of Cardiology, Matsuyama Red Cross 
      Hospital, Ehime, Japan.
FAU - Saku, Keita
AU  - Saku K
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Sakamoto, Takafumi
AU  - Sakamoto T
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan.
FAU - Tsutsui, Hiroyuki
AU  - Tsutsui H
AD  - Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu 
      University, Fukuoka, Japan; Department of Cardiovascular Medicine, Research 
      Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211118
PL  - United States
TA  - Heart Lung
JT  - Heart & lung : the journal of critical care
JID - 0330057
SB  - IM
MH  - *Angioplasty, Balloon
MH  - Arterial Pressure
MH  - Chronic Disease
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - *Hypertension, Pulmonary
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Artery/surgery
MH  - *Pulmonary Embolism/complications/therapy
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Chronic thromboembolic pulmonary hypertension
OT  - balloon pulmonary angioplasty
OT  - exercise tolerance
OT  - pulmonary arterial compliance
OT  - pulmonary vascular resistance
COIS- Declaration of Competing Interest Kohtaro Abe had received a research grant from 
      Mochida Pharmaceutical Co., Ltd. Keita Saku worked in a department endowed by 
      Omron Healthcare Co. and received honoraria from Abiomed Japan K.K.. Hiroyuki 
      Tsutsui had received honoraria from Daiichi Sankyo, Inc., Otsuka Pharmaceutical 
      Co., Ltd., Takeda Pharmaceutical Company Limited, Mitsubishi Tanabe Pharma 
      Corporation, Boehringer Ingelheim Japan, Inc., Novartis Pharma K.K., Bayer 
      Yakuhin, Ltd., Bristol-Myers Squibb KK, and Astellas Pharma Inc. and research 
      funding from Actelion Pharmaceuticals Japan, Daiichi Sankyo, Inc., and Astellas 
      Pharma Inc.
EDAT- 2021/11/22 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/11/21 20:44
PHST- 2021/03/30 00:00 [received]
PHST- 2021/10/31 00:00 [revised]
PHST- 2021/11/02 00:00 [accepted]
PHST- 2021/11/22 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/11/21 20:44 [entrez]
AID - S0147-9563(21)00271-5 [pii]
AID - 10.1016/j.hrtlng.2021.11.003 [doi]
PST - ppublish
SO  - Heart Lung. 2022 Mar-Apr;52:8-15. doi: 10.1016/j.hrtlng.2021.11.003. Epub 2021 
      Nov 18.