PMID- 34803907
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20230921
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Metabolically Abnormal But Normal-Weight Individuals Had a Higher Risk of Type 2 
      Diabetes Mellitus in a Cohort Study of a Chinese Population.
PG  - 724873
LID - 10.3389/fendo.2021.724873 [doi]
LID - 724873
AB  - AIMS: Obesity is a heterogeneous disease in terms of body mass index (BMI) and 
      metabolic status. The purpose of this study was to investigate the risk of type 2 
      diabetes mellitus (T2DM) in subjects with metabolically abnormal but normal 
      weight (MANW) in China. MATERIALS AND METHODS: A prospective cohort with a total 
      of 17,238 participants of the Zhejiang metabolic syndrome cohort was recruited. 
      According to the standard of the Working Group on Obesity in China, general 
      obesity is defined. Metabolic abnormality was defined as two or more abnormal 
      components (elevated triglycerides (TG), low high-density lipoprotein cholesterol 
      (HDL-C), elevated systolic blood pressure (SBP) or diastolic blood pressure (DBP) 
      or use of antihypertensive therapy, and elevated fasting plasma glucose or 
      antidiabetic treatment). The hazard ratio (HR) and its 95% CI were calculated 
      using a multiple regression model, adjusted for the potential confounding 
      factors. RESULTS: Compared with metabolically normal and normal weight (MNNW) 
      subjects, the metabolically abnormal and obesity/overweight (MAO) subjects had 
      the highest risk of T2DM disease, with an HR of 4.67 (95% CI: 3.23-6.76), 
      followed by MANW subjects (HR = 2.61, 95% CI: 1.74-3.92) and metabolically normal 
      but obesity/overweight (MNO) subjects (HR = 2.09, 95% CI: 1.29-3.38) after 
      adjusting for age, sex, smoking, drinking, physical activity, and family history 
      of diabetes. Compared with that in the MNNW subjects, the HR in MANW subjects was 
      significantly higher than that in MNO subjects. In normal-weight subjects, the HR 
      of T2DM was significantly positively correlated with the number of components 
      with metabolic abnormalities. CONCLUSIONS: MANW subjects had a higher risk of 
      T2DM. MANW subjects should be given more attention in the prevention and control 
      of common chronic diseases.
CI  - Copyright (c) 2021 Chen, Zhou, Dai, Zhao, Zhu and Zhang.
FAU - Chen, Qiannan
AU  - Chen Q
AD  - Basic Discipline of Chinese and Western Integrative, School of Public Health, 
      Zhejiang Chinese Medical University, Hangzhou, China.
FAU - Zhou, Yaohan
AU  - Zhou Y
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang 
      University, Hangzhou, China.
FAU - Dai, Chen
AU  - Dai C
AD  - Department of Endocrinology and Institute of Cardiovascular Diseases, Putuo 
      District People's Hospital , Zhoushan, China.
FAU - Zhao, Gang
AU  - Zhao G
AD  - Department of office Hangzhou Center of Disease Control and Prevention, Hangzhou, 
      China.
FAU - Zhu, Yimin
AU  - Zhu Y
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Zhejiang 
      University, Hangzhou, China.
AD  - Department of Respiratory Diseases, Sir Run Run Shaw Hospital Affiliated to the 
      School of Medicine, Zhejiang University, Hangzhou, China.
FAU - Zhang, Xuhui
AU  - Zhang X
AD  - Affiliated Hangzhou Center of Disease Control and Prevention, Zhejiang University 
      School of Public Health, Hangzhou Center for Disease Control and Prevention, 
      Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211103
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/epidemiology/*etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Ideal Body Weight
MH  - Male
MH  - Metabolic Syndrome/*complications/epidemiology
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC8595277
OTO - NOTNLM
OT  - heterogeneity
OT  - metabolically abnormal but normal weight (MANW)
OT  - metabolically normal but obesity/overweight (MNO)
OT  - obesity
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/23 06:00
MHDA- 2022/02/15 06:00
PMCR- 2021/01/01
CRDT- 2021/11/22 06:40
PHST- 2021/06/14 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/11/22 06:40 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.724873 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Nov 3;12:724873. doi: 
      10.3389/fendo.2021.724873. eCollection 2021.