PMID- 34804178
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2021
DP  - 2021
TI  - The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, 
      and Antioxidant Biomarkers in Asthmatic Rats.
PG  - 4234326
LID - 10.1155/2021/4234326 [doi]
LID - 4234326
AB  - The effects of Curcuma longa (C. longa) on total and differential WBC, 
      inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in 
      bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed. 
      Animals were divided to 5 groups including control (C), asthma (sensitized to 
      ovalbumin), and asthmatic groups treated with 0.75, 1.50, and 3.00 mg/ml C. longa 
      (CL) and 1.25 mug/ml dexamethasone (D) (8 rats in each group). Total and 
      differential WBC count, concentrations of phospholipase A(2) (PLA(2)), total 
      protein (TP), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), immunoglobulin E 
      (IgE), NO(2), NO(3), malondialdehyde (MDA), superoxide dismutase (SOD), catalase 
      (CAT), and thiol in BALF were assessed. Total and most differential WBC counts 
      and BALF levels of PLA(2), TP, IgE, IL-4, and oxidants in asthma group were 
      higher but antioxidants and IFN-gamma levels as well as IFN-gamma/IL-4 ratio were lower 
      than control group (p < 0.001 for all cases). Total WBC and levels of PLA(2), 
      IgE, NO(2), and NO(3) were significantly reduced following treatment with C. 
      longa, compared to asthma group (p < 0.001 for all cases). In groups treated with 
      dexamethasone and two higher concentrations of C. longa, neutrophil and 
      eosinophil counts as well as TP, IL-4, and MDA levels were significantly 
      decreased but IFN-gamma, IFN-gamma/IL-4 ratio, and antioxidants were increased (except 
      IFN-gamma/IL-4 ratio), compared to asthma group (p < 0.05 to p < 0.001). Compared to 
      dexamethasone, C. longa exerted more pronounced effects on lung inflammation, 
      oxidative stress, and immune system in asthmatic rats.
CI  - Copyright (c) 2021 Mohammad Hossein Boskabady et al.
FAU - Boskabady, Mohammad Hossein
AU  - Boskabady MH
AD  - Neurogeneic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Amin, Fatemeh
AU  - Amin F
AUID- ORCID: 0000-0003-0961-7667
AD  - Non-Communicable Diseases Research Center, Rafsanjan University of Medical 
      Sciences, Rafsanjan, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, Rafsanjan 
      University of Medical Sciences, Rafsanjan, Iran.
FAU - Shakeri, Farzaneh
AU  - Shakeri F
AUID- ORCID: 0000-0003-4813-6030
AD  - Natural Products and Medicinal Plants Research Center, North Khorasan University 
      of Medical Sciences, Bojnurd, Iran.
AD  - Department of Physiology and Pharmacology, School of Medicine, North Khorasan 
      University of Medical Sciences, Bojnurd, Iran.
LA  - eng
PT  - Journal Article
DEP - 20211112
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC8604592
COIS- The authors disclose no conflicts of interest.
EDAT- 2021/11/23 06:00
MHDA- 2021/11/23 06:01
PMCR- 2021/11/12
CRDT- 2021/11/22 06:42
PHST- 2021/05/01 00:00 [received]
PHST- 2021/10/04 00:00 [revised]
PHST- 2021/10/13 00:00 [accepted]
PHST- 2021/11/22 06:42 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2021/11/23 06:01 [medline]
PHST- 2021/11/12 00:00 [pmc-release]
AID - 10.1155/2021/4234326 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2021 Nov 12;2021:4234326. doi: 
      10.1155/2021/4234326. eCollection 2021.