PMID- 34804871
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 14
IP  - 11
DP  - 2021
TI  - Human umbilical cord-derived mesenchymal stem cells treatment for refractory 
      uveitis: a case series.
PG  - 1784-1790
LID - 10.18240/ijo.2021.11.20 [doi]
AB  - AIM: To evaluate therapeutic outcomes of human umbilical cord-derived mesenchymal 
      stem cells (HUC-MSCs) treatment in patients with refractory uveitis. METHODS: A 
      retrospective and noncomparative review was performed on four patients with 
      refractory uveitis from December 2013 to December 2017. HUC-MSCs were 
      administered intravenously at a dose of 1x10(6) cells/kg. Clinical response, 
      relapse rate, change of visual acuity, and other metrics were evaluated. RESULTS: 
      All four patients presented with responses to HUC-MSCs treatment, with three 
      males and one female. The numbers of uveitis attacks per year after the HUC-MSCs 
      treatment (0, 2, 0, 0 respectively) all decreased compared with the numbers 
      before the treatment (3, 6, 4, 4 respectively). The oral steroid and 
      immunosuppressive agents were tapered in all patients without recrudescence of 
      ocular inflammation, and three patients discontinued their oral medicine at the 
      last visit. The best corrected visual acuity (BCVA) of 3 patients was improved to 
      varying degrees, and the BCVA of 1 patient remained at 20/20 (Snellen chart) from 
      the first to the last consultation. CONCLUSION: The study provides an effective 
      therapy of HUC-MSCs in maintaining remission in patients affected by uveitis 
      refractory to previous immunosuppressant treatments.
CI  - International Journal of Ophthalmology Press.
FAU - Yang, Jing
AU  - Yang J
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
FAU - Ren, Xin-Jun
AU  - Ren XJ
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
FAU - Chen, Xi-Teng
AU  - Chen XT
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
FAU - Jiang, Yuan-Feng
AU  - Jiang YF
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
FAU - Han, Zhi-Bo
AU  - Han ZB
AD  - National Engineering Research Center of Cell Products, Tianjin 300457, China.
FAU - Han, Zhong-Chao
AU  - Han ZC
AD  - National Engineering Research Center of Cell Products, Tianjin 300457, China.
AD  - Beijing Engineering Laboratory of Perinatal Stem Cells, Beijing Institute of 
      Health and Stem Cells, Beijing 300457, China.
FAU - Li, Xiao-Rong
AU  - Li XR
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
FAU - Zhang, Xiao-Min
AU  - Zhang XM
AD  - Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of 
      National Clinical Research Center for Ocular Disease, Eye Institute and School of 
      Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
LA  - eng
PT  - Journal Article
DEP - 20211118
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC8569569
OTO - NOTNLM
OT  - autoimmune disease
OT  - human umbilical cord-derived mesenchymal stem cells
OT  - refractory uveitis
OT  - therapeutics
EDAT- 2021/11/23 06:00
MHDA- 2021/11/23 06:01
PMCR- 2021/11/18
CRDT- 2021/11/22 06:51
PHST- 2020/07/06 00:00 [received]
PHST- 2021/04/14 00:00 [accepted]
PHST- 2021/11/22 06:51 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2021/11/23 06:01 [medline]
PHST- 2021/11/18 00:00 [pmc-release]
AID - ijo-14-11-1784 [pii]
AID - 10.18240/ijo.2021.11.20 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2021 Nov 18;14(11):1784-1790. doi: 10.18240/ijo.2021.11.20. 
      eCollection 2021.