PMID- 34805201
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211123
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - Case Report: Venoarterial Extracorporeal Membrane Oxygenation Support for 
      Caowu-Induced Cardiac Arrest.
PG  - 731163
LID - 10.3389/fmed.2021.731163 [doi]
LID - 731163
AB  - Introduction: Caowu, the main root of the Aconitum plant, is widely used in 
      China. Aconitine is the main toxic component of Aconitum, which can cause a 
      variety of malignant arrhythmias and lead to death. Four patients who developed 
      malignant arrhythmia after drinking medicinal wine containing Caowu were reported 
      in this study. Cardiac arrest occurred soon after symptom onset. All patients 
      received venoarterial extracorporeal membrane oxygenation (VA-ECMO) support after 
      conservative medical treatment had failed. Patients who were directly transferred 
      to our hospital received VA-ECMO support earlier than patients who were first 
      treated at a local hospital. One patient received hemoperfusion in the emergency 
      room before VA-ECMO support; the other three patients began hemoperfusion after 
      VA-ECMO treatment. Surviving patients who received VA-ECMO earlier after symptom 
      onset showed no obvious neurological complications. The patient who received a 
      longer cardiopulmonary resuscitation time but received hemoperfusion before 
      VA-ECMO had mild neurological complications. The mortality rate was 25% (1 of 4 
      patients). Two patients had thrombotic complications in venous vessels. 
      Conclusions: Cardiogenic shock due to refractory ventricular tachycardia caused 
      by aconitine is lethal. Conservative supportive treatment did not provide a 
      short-term antiarrhythmic effect and the cardiogenic shock was not well 
      controlled. VA-ECMO treatment combined with hemoperfusion is promising temporary 
      support to successfully treat aconitine-induced cardiogenic shock caused by 
      refractory ventricular tachycardia.
CI  - Copyright (c) 2021 Ren, Wang, Chen, Chen and Wang.
FAU - Ren, Binbin
AU  - Ren B
AD  - Department of Infectious Disease, School of Medicine, Affiliated Jinhua Hospital, 
      Zhejiang University, Jinhua, China.
FAU - Wang, Liming
AU  - Wang L
AD  - Department of Intensive Care Unit, School of Medicine, Affiliated Jinhua 
      Hospital, Zhejiang University, Jinhua, China.
FAU - Chen, Kun
AU  - Chen K
AD  - Department of Intensive Care Unit, School of Medicine, Affiliated Jinhua 
      Hospital, Zhejiang University, Jinhua, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Intensive Care Unit, School of Medicine, Affiliated Jinhua 
      Hospital, Zhejiang University, Jinhua, China.
FAU - Wang, Huabin
AU  - Wang H
AD  - Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of 
      Medicine, Jinhua, China.
LA  - eng
PT  - Case Reports
DEP - 20211103
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8595269
OTO - NOTNLM
OT  - Caowu
OT  - VA-ECMO
OT  - aconitine
OT  - heart arrest
OT  - malignant arrhythmias
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/11/23 06:00
MHDA- 2021/11/23 06:01
PMCR- 2021/11/03
CRDT- 2021/11/22 06:53
PHST- 2021/06/26 00:00 [received]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/11/22 06:53 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2021/11/23 06:01 [medline]
PHST- 2021/11/03 00:00 [pmc-release]
AID - 10.3389/fmed.2021.731163 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Nov 3;8:731163. doi: 10.3389/fmed.2021.731163. 
      eCollection 2021.