PMID- 34805412
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20240404
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2021
DP  - 2021
TI  - Reenvisioning Traditional to Regenerative Therapeutic Advances in Managing 
      Nonalcoholic Fatty Liver Disease in Diabetes Mellitus.
PG  - 7692447
LID - 10.1155/2021/7692447 [doi]
LID - 7692447
AB  - Reports indicate the increasing prevalence of liver disorders in diabetes 
      mellitus (DM) patients. Clinically, it has also been revealed that the existence 
      of nonalcoholic fatty liver disease (NAFLD) enhances the incidence of type 2 
      diabetes mellitus (T2DM), while T2DM exacerbates NAFLD to extremely severe forms 
      of steatohepatitis, cirrhosis, and hepatocellular carcinoma. This implies the 
      coexistence and bidirectional nature of NAFLD and T2DM, which function 
      synergistically to drive adverse consequences in clinical practice. For treatment 
      of such comorbid state, though the existing practices such as lifestyle 
      management, traditional Chinese medicines (TCM), and pharmaceuticals have offered 
      somewhat relief, the debate continues about the optimal therapeutic impacts. 
      Recent developments in the field of tissue engineering have led to a renewed 
      interest in novel biomaterial alternatives such as stem cells. This might be 
      attributable to their differentiation potential towards hepatic and pancreatic 
      lineage. These cellular therapies could be further complemented by 
      platelet-derived biomaterials, TCM formulations, or any specific drug. Based on 
      these abovementioned approaches, we aimed to comprehensively analyze various 
      preclinical and clinical studies from traditional to regenerative therapeutic 
      approaches in managing concomitant NAFLD and T2DM.
CI  - Copyright (c) 2021 Lung-Wen Tsai et al.
FAU - Tsai, Lung-Wen
AU  - Tsai LW
AUID- ORCID: 0000-0002-3541-5834
AD  - Department of Medicine Research, Taipei Medical University Hospital, Taipei 
      11031, Taiwan.
AD  - Department of Information Technology Office, Taipei Medical University Hospital, 
      Taipei 11031, Taiwan.
AD  - Graduate Institute of Data Science, College of Management, Taipei Medical 
      University, Taipei 11031, Taiwan.
FAU - Lu, Yi-Hsiang
AU  - Lu YH
AUID- ORCID: 0000-0003-4679-4021
AD  - Department of Otolaryngology, Taipei Medical University Hospital, Taipei 11031, 
      Taiwan.
FAU - Dubey, Rajni
AU  - Dubey R
AUID- ORCID: 0000-0002-0506-7744
AD  - Department of Medicine Research, Taipei Medical University Hospital, Taipei 
      11031, Taiwan.
FAU - Chiou, Jeng-Fong
AU  - Chiou JF
AUID- ORCID: 0000-0002-5274-9131
AD  - Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 
      11031, Taiwan.
AD  - Department of Radiology, School of Medicine, College of Medicine, Taipei Medical 
      University, Taipei 11031, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211111
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/physiopathology/*therapy
MH  - Diffusion of Innovation
MH  - Drugs, Chinese Herbal/adverse effects/*therapeutic use
MH  - *Healthy Lifestyle
MH  - Humans
MH  - Hypoglycemic Agents/adverse effects/*therapeutic use
MH  - Incidence
MH  - Liver/*physiopathology
MH  - Non-alcoholic Fatty Liver Disease/diagnosis/epidemiology/physiopathology/*therapy
MH  - Prevalence
MH  - *Regenerative Medicine
MH  - Risk Reduction Behavior
MH  - *Stem Cell Transplantation/adverse effects
MH  - *Tissue Engineering
MH  - Treatment Outcome
PMC - PMC8601846
COIS- The authors declare that there is no conflict of interest regarding the 
      publication of this paper.
EDAT- 2021/11/23 06:00
MHDA- 2022/03/04 06:00
PMCR- 2021/11/11
CRDT- 2021/11/22 06:55
PHST- 2021/10/06 00:00 [received]
PHST- 2021/10/23 00:00 [accepted]
PHST- 2021/11/22 06:55 [entrez]
PHST- 2021/11/23 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2021/11/11 00:00 [pmc-release]
AID - 10.1155/2021/7692447 [doi]
PST - epublish
SO  - J Diabetes Res. 2021 Nov 11;2021:7692447. doi: 10.1155/2021/7692447. eCollection 
      2021.